Tinidazole

Tinidazole - a drug that has antibacterial, antiprotozoal and antifungal effects.

This medication is widely used in the field of modern medicine to combat giardiasis, trichionosis in acute or chronic form, infectious lesions, provoked by bacteria of anaerobic origin, as well as infectious diseases accompanying the development of ulcerative lesions of the gastrointestinal tract.

The mechanism of action of tinidazole is explained by its ability to inhibit synthesis and damage the structure of bacterial DNA.

Clinical and pharmacological group

Antiprotozoal agent with antibacterial action.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Tinidazole cost in pharmacies? The average price is at the level of127 rubles.

Composition and form of release

Tinidazole is available in the form of tablets that have a white or almost white color. The tablet has a round biconvex shape and contains 500 mg of the active ingredient (tinidazole).

As auxiliary components of the drug are cornstarch, lactose, methylhydroxybenzoate, magnesium stearate, purified talc, anhydrous colloidal silicon.

To the preparation Tinidazole the instruction is enclosed in each cardboard package, with 1 or 4 tablets.

pharmachologic effect

Tinidazole is used as an effective antiprotozoal agent with high antibacterial efficacy. The mechanism of its action is due to a qualitative inhibition of synthesis, as well as damage to the DNA structure of the pathogen. The drug is effective against a number of anaerobic bacteria, as well as Lamblia intestinalis, Trichomonas vaginalis, Entamoeba histolytica.

Bioavailability of Tinidazole is approximately 100%, since the degree of its absorption is very high. The maximum concentration of the drug in the blood is reached 2 hours after admission and is 40-51 μg / ml with 2 g of the drug, and after 24 hours it decreases to 11-19 μg / ml. Up to 1 μg / ml the concentration decreases after 72 hours after administration.

Tinidazole has the property of penetrating through the BBB and through the placental barrier and excreted in breast milk for 72 hours after ingestion. Metabolism of the drug occurs in the liver, with the formation of pharmacologically active derivatives that can suppress the growth of anaerobic bacteria and enhance its effect. Approximately 50% of the drug is excreted in the bile, about 25% is excreted unchanged by the kidneys, and another 12% is metabolites.

Indications for use

Tinidazole is indicated for use in patients with the following types of infections:

1. Giardiasis.
2. Amoebiasis (including hepatic).
3. Trichomoniasis.
4. Different combinations of anaerobic bacteria.
5. Mixed anaerobic-aerobic infections (requires an additional prescription of antibiotics).
6. Detection of gastric ulcer caused by Helicobacter pylori (together with antibiotics and bismuth preparations) in the human body.

Tablets are prescribed for prophylactic purposes during the postoperative period to stop the development of anaerobic bacteria.

Contraindications

Contraindications:

• people who have hypersensitivity to tinidazole;
• with violations of hematopoiesis;
• diseases of the nervous system in the period of exacerbation;
• women in the first months of pregnancy and breastfeeding.

The drug is not taken simultaneously with alcohol. If a person suffers from nausea or vomiting, then treatment with Tinidazole should be postponed. And also it is not prescribed simultaneously with an ethionamide.

Intended use for pregnancy and lactation

The use of Tinidazole in the first trimester of pregnancy is categorically contraindicated. The use of Tinidazole on other terms is possible only in case of acute necessity.

For the duration of treatment with Tinidazole, breastfeeding should be discontinued.

Dosage and route of administration

As indicated in the instructions for use of the tablet, Tinidazole should be taken orally, to avoid the development of side effects from the digestive system - during or after meals.

Recommended dosing regimes:

• giardiasis, trichomoniasis: adults - 2000 mg once, children - 50-75 mg / kg once. If necessary, take the drug again at the same dose;
• infections in adults caused by anaerobes: the initial dose is 2000 mg once, from 2 days - 1000 mg per day. The course of therapy - 5-6 days;
• intestinal amoebiasis: adults - 2000 mg per day for 2-3 days, children - 50-60 mg / kg for 3 days;
• hepatic amoebiasis: adults - 1500-2000 mg per day for 3-6 days, children - 50-60 mg / kg for 5 days.

To prevent the development of postoperative complications, the drug is prescribed for adults 12 hours before the forthcoming surgical intervention in a dose of 2000 mg.

Side effects

The most common side effects of Tinidazole are:

• allergic reactions: rash, itching, hives, angioedema;
• from the central nervous system: ataxia, dizziness, headache, peripheral neuropathy; rarely convulsions;
• from the gastrointestinal tract: unpleasant aftertaste and dry mouth, diarrhea, nausea, anorexia, vomiting;
• Other: rarely - weakness, transient leukopenia.

Overdose

Cases of an overdose of Tinidazole were not observed. A specific antidote to this drug has not been developed, so standard guidelines for the appearance of symptoms overdose: give the patient an abundant drink, induce vomiting, rinse his stomach, do dialysis.

special instructions

Before you start using the drug, read the special instructions:

1. During the treatment should refrain from drinking alcohol.
2. When applying tinidazole, dark staining of urine is observed.
3. In the treatment of trichomoniasis, simultaneous treatment of both partners should be carried out.
4. When there are side effects from the CNS, tinidazole should be discarded.
5. If treatment lasts more than 6 days, regular monitoring of the picture of peripheral blood should be carried out.
6. For the prevention of postoperative anaerobic infections, doses for children under 12 years of age have not been established.

During the treatment period, patients should refrain from engaging in potentially hazardous activities requiring increased attention and high speed of psychomotor reactions.

Interaction with other drugs

Tinidazole is not compatible with antibacterial drugs (cephalosporins, rifampicin, erythromycin, aminoglycosides), sulfonamides. Phenobarbital helps accelerate the metabolic process. Tinidazole is not prescribed with ethionamide.

The drug enhances the effect of indirect anticoagulants, reducing the dosage of the drug in half reduces the risk of bleeding.

Reviews

We offer you to read reviews of people who used the drug Tinidazole:

1. Marina. We drank together with her husband - they registered her as a remedy for lamblia, the doctor prescribed to drink with the whole family. found lamblia in a child. The course for 3 days with my husband. He's all right, no pobochek, nothing, but I had a terrible bitterness in my mouth all three days, but after the abolition immediately passed and the constipation small, but after the canceling all passed. In the right hypochondrium pulled a couple of times, well, so there is a gall, etc. So pobochki at all different, and at someone in general is not present. Bitterness in the mouth can be tolerated, especially if the drug works.
2. Inna. On a routine examination, she discovered lamblia. The doctor advised to buy Tinidazole. I was very surprised that you only need one application. I studied reviews on the Internet - most patients praised the drug. The price was quite acceptable - found for 20 rubles. After 2 weeks after treatment, I passed a second analysis - Giardia disappeared. I'm glad that my doctor prescribed an inexpensive effective drug.
3. Sasha. Assigned for severe urogenital infection, tinidazole together with nystatin. the treatment was practically inconclusive. But I think that this was not the fault of the drugs, but through the fault of the doctor, who did not do the normal analyzes, did not determine the sensitivity of the pathogen to the drugs. Therefore, from the Fenya appointed a complex, and suddenly help

Analogues

Known antibacterial tablets with a similar effect:

1. Tysol is a structural analogue, the cost is 35-60 rubles.
2. Fazijin is a structural analogue, especially effective for the prevention of postoperative complications, the price is from 230 rubles;
3. Metronidazole - is used to eliminate and prevent infectious pathologies, the causative agents of which sensitive to metronidazole, including anaerobic bacteria, the price in pharmacies - from 80 to 160 rubles;
4. Dazolik - is indicated for trichomoniasis, abscess of the liver, extraintestinal invasion, average cost - 300 rubles;
   Intesol - is used in severe infectious processes, complicated by sepsis, peritonitis, abscesses;
   Tiniba - copes with aerobic diseases, is shown at eradication Helikobakter Pilori in a complex with other antibiotics, cost - from 150 rubles.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Keep the tablets out of the reach of children in a dark, cool place, no more than 4 years from the date of manufacture, which is indicated on the package.

After the expiration date the product is disposed of.

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