Veroshpiron

Veroshpiron refers to potassium-sparing diuretics of synthetic origin.

It is used in medical practice to adjust the water and electrolyte balance in the human body. The main active potent component of the drug is spironolactone.

On this page you will find all information about Veroshpiron: the full instruction on the application for this medicine, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Veroshpiron. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Potassium-sparing diuretic.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Veroshpiron cost? The average price in pharmacies is at the level of220 rubles.

Form of issue and composition

The drug is available in the form of capsules and tablets. Active elemental drug Veroshpiron, from which it helps at high pressure, is spironolactone. The active substance is contained in an amount of 25 mg for tablets, 50 or 100 mg for capsules.

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Additional substances in the tablets are talc, silicon dioxide, lactose monohydrate, magnesium stearate, corn starch. Capsules consist of sodium lauryl sulfate, lactose monohydrate, magnesium stearate, corn starch. In the lid and body of the capsule, gelatin, dyes and titanium dioxide are also contained.

Pharmacological effect

The active substance spironolactone, according to the instructions, is a component acting opposite to the adrenal hormone aldosterone. Acts in the kidneys - nephron, eliminates the delay of fluid and sodium, suppresses the potassium-releasing effect. Spironolactone inhibits the production of renal tubular enzymes. By binding to receptors, increases the withdrawal of sodium and chlorine ions with water and urine, reduces the loss of potassium ions, lowers the acidity of urine. According to doctors, has an antihypertensive effect due to the diuretic properties of the hormone aldosterone.

After intake is fully absorbed in the gastrointestinal tract, bioavailability is 100%, eating increases it to the maximum. The highest concentration of spironolactone reaches 2-6 hours after the morning reception. The substance binds to plasma proteins by 98%, poorly penetrates organs and tissues, but metabolites can overcome the placental barrier and enter the breast milk.

Indications for use

According to the instructions, Veroshpiron is appointed at:

Conditions accompanied by secondary hyperaldosteronism, including nephrotic syndrome, liver cirrhosis and other conditions accompanied by edema;
Edema on a background of chronic heart failure (as the main drug or in combination with other drugs);
Primary hyperaldosteronism (Crohn's syndrome) - a short time in the preoperative period;
Essential hypertension (in combination with other drugs);
Hypokalemia or hypomagnesemia (for the prevention of diuretic treatment).

Assign also Veroshpiron for the purpose of establishing a diagnosis of primary hyperaldosteronism.

Contraindications

Contraindications to the use of Veroshpiron are:

Anuria;
Severe renal insufficiency;
Lactose intolerance, lactase enzyme deficiency, glucose-galactose malabsorption;
The period of pregnancy and breastfeeding;
Children up to three years;
Hypersensitivity to any of the components of the drug;
Hyponatremia;
Hyperkalemia.

With care, Veroshpiron is prescribed to patients with metabolic acidosis, hypercalcemia, diabetes mellitus, diabetic nephropathy, hepatic insufficiency, cirrhosis of the liver, as well as elderly people, women with a broken menstrual cycle, with an increase in the mammary glands and with local or general anesthesia.

Application in pregnancy and lactation

The use of Veroshpiron is contraindicated in women during pregnancy and lactation.

If it is necessary to prescribe this drug to breast-feeding mothers, it is recommended to stop breastfeeding, because spironolactone can penetrate into the milk and have a negative impact on the baby's body.

Instructions for use

The instructions for use indicate that the dosage of Veroshpiron depends on the disease:

With idiopathic hyperaldosteronism, the drug is prescribed in a dose of 100-400 mg / day.
In essential hypertension, the daily dose for adults is usually 50-100 mg once and can be increased to 200 mg, while increasing the dose should be gradual, 1 every 2 weeks. To achieve an adequate response to therapy, the drug should be taken at least 2 weeks. If necessary, adjust the dose.
With hypokalemia and / or hypomagnesemia caused by diuretic therapy, Veroshpiron is prescribed at a dose of 25-100 mg / day, once or in several doses. The maximum daily dose is 400 mg if oral potassium preparations or other methods of replenishing its deficiency are ineffective.
With pronounced hyperaldosteronism and hypokalemia, the daily dose is 300 mg (maximum 400 mg) for 2-3 doses, with the improvement of the condition, the dose is gradually reduced to 25 mg / day.
In the diagnosis and treatment of primary hyperaldosteronism as a diagnostic tool for a short diagnostic test Veroshpiron prescribed for 4 days to 400 mg / day, distributing the daily dose for several doses per day. With an increase in the concentration of potassium in the blood at the time of taking the drug and lowering it after cancellation it can be assumed that there is a primary hyperaldosteronism. With a long diagnostic test, the drug is administered at the same dose for 3-4 weeks. When the correction of hypokalemia and arterial hypertension is achieved, it is possible to assume the presence of primary hyperaldosteronism.
After the diagnosis of hyperaldosteronism is established using more accurate diagnostic methods, as a short course of preoperative therapy of primary hyperaldosteronism Veroshpiron should be taken in a daily dose of 100-400 mg, dividing it into 1-4 admission during the entire period of preparation for a surgical operation. If the operation is not indicated, then Veroshpiron is used for long-term maintenance therapy, with This is the lowest effective dose that is selected individually for each patient.
With edematic syndrome against a background of chronic heart failure, the drug is prescribed daily for 5 days to 100-200 mg / day in 2-3 doses, in combination with a "loop" or thiazide diuretic. Depending on the effect, the daily dose is reduced to 25 mg. The maintenance dose is selected individually. The maximum daily dose is 200 mg.
When swelling against cirrhosis of the liver, the daily dose of Veroshpiron for adults is usually 100 mg if the ion ratio sodium and potassium (Na + / K +) in urine exceeds 1.0. If the ratio is less than 1.0, the daily dose is usually 200-400 mg. The maintenance dose is selected individually.
In the treatment of edema against the background of nephrotic syndrome, the daily dose for adults is usually 100-200 mg. No effect of spironolactone on the main pathological process was found, and therefore the use of this drug is recommended only in cases when other types of therapy are ineffective.

In edema in children, the initial dose is 1-3.3 mg / kg body weight or 30-90 mg / m2 / day in 1-4 doses. After 5 days, dose adjustment is performed and, if necessary, it is increased 3 times as compared with the original dose.

Side effects

Veroshpiron can provoke the appearance of such side effects from various body systems, such as:

Hemopoiesis: thrombocytopenia, agranulocytosis, megaloblastosis.
CNS: ataxia, headaches, drowsiness and confusion, impaired concentration, in severe cases, lethargy.
GIT: exacerbation of gastritis, constipation or diarrhea, internal intestinal bleeding, intestinal colic.
Metabolism: increased urea concentration, hyperchloremic acidosis, alkalosis, hyperuricemia.
urinary system: acute renal failure.
Muscular system: spasms and spasm of the calf muscles.
Endocrine system: coarsening of the voice in women, increasing mammary glands in men, reducing or losing potency, reducing the function of erection. Similarly, women may experience bleeding during the period of established menopause, or the absence of menstruation in reproductive age, mammary gland pain of unknown etiology and hirsutism (male-type hair growth).

Based on the above list, Veroshpiron has a number of side effects.

Overdose

Overdose is expressed in such symptoms:

confusion of thoughts;
drowsy condition;
nausea and vomiting;
diarrhea;
rash on the skin;
dehydration.

In case of observing these symptoms, it is necessary to arrange gastric lavage (provoke vomiting) and visit a doctor. The help is reduced to symptomatic therapy.

special instructions

During treatment with spironolactone, alcohol intake is prohibited.
You should avoid rapid weight loss.
Hyperkalemia in patients with severe heart failure
Spironolactone may increase the risk of hyperkalemia in patients with diabetic nephropathy.
Caution should be exercised in appointing patients prone to acidosis or hyperkalemia due to the underlying disease (eg, diabetes mellitus).
Care should also be taken in patients with moderate renal insufficiency (serum creatinine between 1.2 mg / 100 ml and 1.8 mg / 100 ml or creatinine clearance between 60 ml / min and 30 ml / min), hypotension or hypovolemia.
The composition of the dosage form includes lactose. The drug should not be given to patients with rare congenital forms of lactose intolerance: lactase deficiency Lappa, glucose-galactose malabsorption.
Treatment should be discontinued or suspended if the potassium level in the blood exceeds 4 mg / dl.
Therapy with spironolactone can disrupt the process of determining serum and digoxin, plasma cortisol and epinephrine.
Concomitant intake of potassium-containing supplements, a diet rich in potassium, intake of other potassium-sparing diuretics, use of potassium-containing substitutes salts, administration of ACE inhibitors, angiotensin II antagonists, aldosterone receptor antagonists, heparin or low molecular weight heparins, trimethoprim or other drugs that cause hyperkalemia, can lead to severe hyperkalemia, especially in patients with renal insufficiency.
Hyperkalemia can be life threatening. Patients with severe heart failure should carefully monitor serum potassium levels. If the potassium level in the blood exceeds 3.5 mmol / l, you should avoid taking potassium-sparing diuretics. It is recommended to monitor the level of potassium and creatinine in the blood one week after the start of treatment, and then every six months.
Spironolactone therapy can cause a transient increase in serum urea nitrogen, especially in patients with an existing renal dysfunction and hyperkalemia. Spironolactone can cause the development of reversible hyperchloremic metabolic acidosis. Thus, in patients with impaired renal and hepatic function, as well as in elderly patients, biochemical indicators of kidney function and electrolyte balance should be regularly examined.

Drug Interactions

GCS and diuretics mutually reinforce and accelerate diuretic and natriuretic effects.
The drug enhances the metabolism of phenazol, triptorelin, buserelin, gonadorelin, reduces the sensitivity of blood vessels to norepinephrine.
Veroshpiron reduces the effectiveness of anticoagulants, indirect anticoagulants and toxicity of cardiac glycosides.
When taking Veroshpiron with potassium preparations, potassium supplements and potassium-sparing diuretics, ACE inhibitors (acidosis), antagonists angiotensin II, aldosterone blockers, indomethacin, cyclosporine increases the risk of hyperkalemia.
Veroshpiron increases the toxic effect of lithium due to a decrease in its clearance, accelerates the metabolism and excretion of carbenoxolone, the latter in turn contributes to the retention of sodium.

Reviews

We picked up some of the people's feedback on Veroshpiron:

Dmitriy. Personally, I have a lot of side reactions to veroshpiron. I was appointed by his doctor, drank as they said and when I received the first pill my nightmare began. I'm not saying that the medicine is not effective, but I had a lot of unpleasant sensations because of it: nausea, the head was spinning, before the eyes of "fly" and even vomiting. He asked the attending physician to change the drug for me, since the second reception of veroshpiron was just as "enchanting". Apparently I have some kind of individual intolerance to its components. In turn, my mother, he is helping not for the first year to fight with swelling of the leg and is quite effective.
Elena. I became acquainted with the action of veroshpiron after I tried to get rid of the abundant vegetation on my face for a long time. What only I did not try, nothing helped. At first I reacted skeptically to the fact that the cosmetologist advised me to undergo treatment with veroshpiron, and prescribed a prescription. Somehow I could not believe that a diuretic medicine could save me from my problem. Imagine my surprise when, after the 5th day of admission, I saw a significant difference on my face. Vegetation just began to disappear before our eyes. Thanks to the competent doctor. I advise everyone.
Catherine. Veroshpiron was appointed to me by my gynecologist two years after the birth, because there were significant weight problems and swelling. I drank veroshpiron a month and really the swelling was asleep and I even lost some weight and the volumes left a little.
Michael. At the last appointment with a doctor, I was diagnosed with essential hypertension. On its background began to swell limbs, which was unpleasant. To cope immediately with two problems, the doctor prescribed Veroshpiron capsules. I drank them in the mornings, and by the evening swelling was not so pronounced. Two weeks later, I was given a dose increase, because the effect of the application was weak.

Reviews of the side effects of Veroshpirona are not common. Some of the patients noted the appearance of headaches, weakness, diarrhea, nausea on the background of taking the drug. There are individual reviews of the appearance of muscle cramps. All authors of the reviews note that side effects quickly disappeared after drug withdrawal

Analogues

Veroshpiron has several structural analogues that contain the same list of components and have a similar effect on the body.

These include:

Vero-Spironolactone;
Spironol;
Verospilactone;
Spiriks;
Aldactone

Before using analogues, consult your doctor.

Storage conditions and shelf life

The shelf life of Veroshpiron tablets and capsules is 5 years. The drug should be stored in a dry, dark place inaccessible to children at an air temperature of not more than + 30 ° C.