Norfloxacin - instructions for use and indications, dosage form, dosage, composition and price

Composition and Form of Release

Guideline for Use Norfloxacin describes two dosage forms of a medicament - round tablets of yellow color, film-coated with a risk on one side. The medicine is applied strictly by mouth. The tablets are packed in contiguous cell packs of 10 pcs.1 cardboard pack contains 1-2 packs of cells, instructions for use. There is another form - ear and eye drops. Pour 5 ml each into the dropper bottles. Peculiarities of chemical composition of tablets:

Components	Name of substances	Concentration 1 table, mg
Active ingredient:	norfloxacin	200/400
Auxiliary components:	microcrystalline cellulose	120,4 / 240,8
colloidal silica( aerosil)	3,6 / 7,2
magnesium stearate	3,6 / 7,2
Croscarmellose sodium	10,8 / 21,6
Crospovidone	21,6 / 43,2
Composition of the coating:	of hypromellose	6,57 /13.14
titanium dioxide	2.2 / 4.4
macrogol 6 000	2.2 / 4.4
quinoline dye yellow	0,03 / 0,06

In the chemical composition of eye and ear drops with pronounced antibacterial properties disodium edetate, buffer solution, sodium chloride, decamethoxin, purified water serve as auxiliary components. Each carton contains 1 bottle-dropper, instructions for use. This form is intended for external application.

Pharmacological properties of

Tablets Norfloxacin is an antibacterial drug of the pharmacological group of fluoroquinolones. The same active substance with pronounced bactericidal properties disrupts the integrity of the DNA of pathogenic microorganisms, contributes to rapid destruction of harmful microbes and further excretion from the body. This drug is active against such infections as:

• staphylococcus aureus;
• Escherichia;
• of clostridium;
• gonococcal;
• hafnium;
• protey;
• Klebsiella;
• influenza hemophilus;
• enterobacterium;
• chlamydia;
• shigella;
• streptococci;
• Salmonella.

Eating food slows the adsorption of the medication, so a single dose of the drug is recommended for use on an empty stomach. After oral administration, 40% is absorbed from the digestive tract. The maximum concentration in the blood plasma drug reaches after 2 hours. The therapeutic effect lasts for 12 hours. Metabolism occurs in the liver. Antibacterial drug is produced together with bile and urine.

Norfloxacin is an antibiotic or not

This medication is an antibiotic of the 2nd generation, the active ingredient of the same name is characterized by stable antibacterial, antiseptic activity. Representatives of the pharmacological group of fluoroquilones do not have natural analogs, they differ in their origin. Norfloxacin is an antibacterial drug whose structure is different with the structure of natural( natural) antibiotics.

Indications for use

Medication Norfloxacin is prescribed for infectious inflammatory processes, localized in the urinary organs, respiratory and reproductive system, soft tissues. It is appropriate such a pharmaceutical purpose for inflammation of the uterus and appendages, diseases of the ears and eyes of infectious genesis. Instruction for use contains a complete list of medical indications:

• cervicitis, adnexitis, endocervicitis, endometritis;
• chlamydia, uncomplicated gonorrhea;
• urethritis, cystitis, pyelonephritis;
• "travelers' diarrhea";
• endometritis, cervicitis, prostatitis;
• abscess, phlegmon, erysipelas, pyoderma;
• sinusitis, tonsillitis, otitis media, sinusitis;
• infection Helicobacter pylori, salmonellosis, shigellosis;
• conjunctivitis, keratitis, meibomite, dacryocystitis, blepharoconjunctivitis, keratoconjunctivitis, blepharitis, corneal ulcer;
• external and middle otitis media, prophylaxis after surgical interventions.

Method of application and dosage

Norfloxacin in the form of tablets is intended for oral administration, drops for external use. The course of treatment lasts 7-14 days. If there is no positive dynamics 3 days after the start of drug therapy, you need to see a doctor and adjust the dosage individually, choose a reliable analogue. Daily doses depend on the form of release, the age of the patient, the nature and stage of the pathological process, described in the instructions for use.

Tablets Norfloxacin

The medication is intended for oral use. The daily dose is 1 table.2-3 times per day for 7-14 days. Pills are required to swallow whole, do not chew, drink plenty of water. The course of treatment determines the nature of the pathological process:

• Norfloxacin for cystitis should be taken 7-12 days;
• for urinary tract infection to be treated 3-7 days;
• with gastroenteritis medication prescribed a course of 3-5 days;
• with proctitis, cervicitis, urethritis or pharyngitis is supposed to take 800 mg once;
• with typhoid fever, recurrence of chronic infections to be treated 14 days.

Drops Norfloxacin

A medical preparation in liquid form is prescribed for diseases of the ears and eyes of an infectious and inflammatory genesis. At the stage of relapse, the patient needs to instill 2 drops of Norfloxacin in one ear( eye).Then it is required to repeat the procedure for the second focus of the pathology. The patient is recommended to spend 3-4 procedures per day. The course of treatment is not recommended to stop until the disappearance of anxiety symptoms of blepharitis, conjunctivitis and other pathologies of the eyes and ears.

Special instructions

The drug Norfloxacin for pyelonephritis or other diseases of the genitourinary system is prescribed for 7-10 days. If the patient is taking anticonvulsants, this should be reported in advance to the doctor in charge. Otherwise, the development of a seizure may not be ruled out. Other instructions for patients are described in detail in the instructions for use:

1. When treated with an antibacterial agent, it is required to abandon the management of power mechanisms, not to engage in intellectual activity. This is explained by the increased drowsiness of the patient and dizziness.
2. During medical therapy, direct sunlight should be avoided, more fluid should be taken, kidney function and blood coagulability should be monitored( especially when performing surgery).
3. In the treatment of patients with chronic renal failure, after kidney, lung or heart transplantation, over the age of 60 years, the risk of rupture of tendons and the development of tendinitis increases.
4. The dosages recommended in the instructions are prohibited because the active ingredients gradually accumulate in the kidneys, and there are difficulties in removing them.
5. The drug sometimes causes peripheral neuropathy, so when the first sensation of numbness of the limbs is required, it is urgently necessary to stop taking the medication and contact the treating doctor.
6. A medical product is not recommended as part of a comprehensive therapy for syphilis, with suspicion of pseudomembranous colitis.
7. If this medication causes confusion, hallucinations, tremors of the extremities, internal anxiety, toxic psychoses, it is urgently needed to consult a doctor for advice.

Norfloxacin during pregnancy

When carrying a fetus, this pharmaceutical use is contraindicated. Clinical studies have confirmed that the effect of Norfloxacin has a negative impact on the fetal development of the fetus. When lactation is used, this medication is also prohibited. The active ingredients are excreted with human milk. When treating a nursing mother, it is required to temporarily stop breastfeeding, to transfer the baby to the adapted mixture.

Norfloxacin for children

Patients under 12 years of age are not prescribed an antibacterial drug in the form of tablets for oral use. Clinical studies of this category of patients were not performed in practice. Norfloxacin drops for external use to children are prescribed individually, daily dosages depend on the nature of the pathological process.

Drug Interaction

Antibacterial agent Norfloxacin is prescribed in a complex treatment regimen. The instructions for use contain information on drug interactions with representatives of other pharmacological groups:

1. Norfloxacin lowers the clearance of Teofillin, slows the action of nitrofurans, increases the concentration of indirect anticoagulants in the blood serum.
2. With simultaneous use with antihypertensive drugs, the blood pressure index drops sharply.
3. In combination with barbiturates, it is necessary to control the pulse, blood pressure, cardiac activity.
4. This antibacterial agent is not prescribed simultaneously with enterosorbents, magnesium preparations, antacid agents, since the antibacterial effect is weakened.
5. Combination with preparations containing iron, calcium, bismuth and zinc is forbidden, since the desired therapeutic effect is poorly expressed.
6. Drug enhances the therapeutic effect of hypoglycemic agents, which is important to know for patients with diabetes.
7. The antibacterial drug slows the caffeine withdrawal period from the body.
8. When used simultaneously with cyclosporins, serum creatinine levels increase.
9. In combination with anesthetics, it is required to monitor the blood pressure level.

Side effects of

Norfloxacin is well tolerated by the body. In some clinical cases, side effects develop, described in detail in the instructions for use:

• digestive tract: nausea, vomiting, diarrhea, lack of appetite, increased liver and increased liver transaminase activity, increased salivation, gastralgia( abdominal pain);
• nervous system: drowsiness, inner anxiety, vasculitis, dizziness, migraine attacks, unreasonable feeling of fear, hallucinations, convulsions;
• cardiovascular system: arrhythmia, tachycardia, arterial hypotension( hypotension), change in electrocardiogram indicators;
• urinary system: crystalluria, albuminuria, renal failure, glomerulonephritis, interstitial nephritis, polyuria, dysuria, hypercreatininaemia, urethral hemorrhages;
• musculoskeletal system: arthralgia, tendon rupture, tendonitis;
• sensory organs: photophobia, decreased visual acuity, chemosis, conjunctival hyperemia;
• hematopoiesis: leukocytosis, hematocrit decrease, hemolytic anemia, granulocytopenia, agranulocytosis, eosinophilia;
• Skin: Allergies in the form of skin rashes, erythema, urticaria, swelling and redness of the epidermis, bronchospasm, toxic epidermal necrolysis.

Overdose

With systematic excess of daily dosages, the patient's condition deteriorates sharply. Symptoms of overdose: renal failure, violation of water-electrolyte balance, increased side effects from the digestive tract. The patient is required to rinse the stomach, forcibly provoke vomiting. The following is an oral intake of intestinal enterosorbents, symptomatic treatment. There is no specific antidote. The use of adequate hydration therapy with forced diuresis is not ruled out.

Contraindications

Norfloxacin is not available to all patients. The instructions for use contain a list of medical contraindications:

• individual intolerance to the body of fluoroquinolones;
• acute deficiency of glucose-6-phosphate dehydrogenase;
• pregnancy;
• breastfeeding;
• age restrictions up to 18 years;
• with caution: atherosclerosis of vessels, epilepsy, renal and hepatic insufficiency, diabetes mellitus.

Terms of Sale and Storage

Norfloxacin is a prescription medication that is sold in pharmacies. According to the instructions for use, the medicine must be stored in a dry and dark place, inaccessible to sunlight and small children. Shelf life - 2 years from the date of issue.

Norfloxacin analogues

If side effects occur at the beginning of the course, you need to replace the medication. Reliable Norfloxacin analogues and their brief description:

1. Nolitsin. Structural analogue for oral administration, which is often prescribed for infections of the genitourinary system. According to the instructions, you need to drink 1 table.three times a day for 10-14 days.
2. Loxon. It is an Indian antibacterial drug in the form of tablets, well known to domestic pharmacology. According to the instruction, the patient is prescribed 1 unit.per day. The course of treatment - up to 10 days, depends on the disease.
3. Norbaktin. This is a potent anti-sine throat in the form of tablets for oral administration. The drug is effective against bacteria of the gram-positive and gram-negative. Assign a course of 7-14 days, dosages depend on the nature of the disease, described in the instructions.
4. Normax. Tablets with antibacterial effect recommend patients from 14 years of age and older. According to the instructions, the daily dose is 1 tab.twice a day. In the absence of positive dynamics for 3 days, the drug should be replaced by a strong analog.
5. Norillet. A drug from the group of fluoroquinols for systemic action in the body. The daily doses and the course of treatment are described in the instructions, depend on the patient's age and the nature of the disease.
6. Sofazine. Effective medication tablet form release for the treatment of infections of the urinary and respiratory tract, soft tissues, ENT organs. The course of drug therapy varies from 7 to 14 days, positive changes are observed after 2-3 days of regular use of tablets.
7. Spectrum. It is an antibacterial agent with a broad spectrum of action. According to the instructions, treatment is required to be carried out on an empty stomach, taking 1 tablet each.2-3 times per day. The duration of drug therapy is determined individually.
8. Negaflox. These are tablets and drops with a pronounced antibacterial effect. The second form of release is often used in otolaryngology and ophthalmology to suppress infectious and inflammatory processes.

Price of Norfloxacin

The cost of this medication depends on the form of release and the manufacturer. The average price of a tablet form of Norfloxacin is 145-200 rubles per package, drops of 5 ml cost 100-150 rubles. Examples of prices:

Names of metropolitan drugstores	Price of tablets №10, rub.
Online pharmacy "Dialogue"	118
ZdravZona	121
ASNA	122
Truck	136
NIKA	138
Kremlin drugstore	140
Pharmacy "Sunny"	142

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Reviews

Irina, 38 years old

Antibacterial drug Norfloxacin in angina took a seven-day course. The disease was cured, but the dysbiosis was working. I had to take an additional course of probiotics. In general, the treatment was satisfied, the main thing is to drink tablets correctly, do not break the dosage. My throat stopped hurting on the second day, on the amendment I went on day 5.

Marina, 41 years old

Norfloxacin is prescribed for me with an external otitis. I used the drug in the form of drops. I dropped 2 drops in each ear for 2 weeks three times a day. Quickly the shooting pains disappeared, started to sleep normally, and soreness was gone when swallowing. The medicine is inexpensive, available at every pharmacy.

Svetlana, 48 years old

Norfloxacin in the form of drops regularly used in relapsing conjunctivitis. The drug is available in all pharmacies, inexpensive, it works without side effects. I dripped my eyes three times a day for 10 days. This time was enough to solve the health problem. I took the medicine for a note, as conjunctivitis worsens regularly.