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Tablets "Allapinin" refer to the first class of antiarrhythmic drugs.

The drug is able to block sodium channels in the membranes of cardiomyocytes. It provokes retardation of intraventricular and atrioventricular conduction, shortens functional and effective refractory periods in the atria, bundle of the Hyis, AV-node and fibers of Purkinje. The tool has absolutely no effect on the duration of the QT-interval, the frequency of contractions.

On this page you will find all information about Allapinin: full instructions for use with this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Allapinin. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antiarrhythmic drug class 1 C.

Conditions of leave from pharmacies

The drug is released by prescription.

Price list

How much does Allapinin cost? The average price in pharmacies is at the level of550 rubles

Form of issue and composition

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Allapinin comes in the form of:

  • Substance-powder - in banks of dark glass of 0.5 kg and 1 kg, or in bags of polyethylene double-layered for 0.5 kg, 1 kg, 1.5 kg, 2 kg and 3 kg;
  • Round biconvex tablets of white color to , 25 g - in packages of contiguous cells for 10 or 30 pieces.

One tablet contains:

  • Lappakonitina hydrobromide with concomitant alkaloids - 0.025 g;
  • Sucrose - 0.0655 g;
  • Potato starch - 0.0075 g;
  • Croscarmellose sodium - 0.001 g;
  • Calcium stearate - 0.001 g.

Pharmacological properties

Allapinin is included in the first class of antiarrhythmic drugs. Has a membrane-stabilizing effect and is able to block sodium channels in the membranes of cardiomyocytes. The drug worsens atrioventricular and intraventricular conduction, reduces the effective and functional refractory period in the atria, the bundle of His and the fibers of Purkinje. Does not affect the duration of the QT-interval, which depends on the heart rate, nor on the frequency of contractions.

Allapinin, according to the instructions, does not affect the contractility of the myocardium with the initial absence of signs of cardiac insufficiency. It does not slow the conductivity of the atrioventricular node along the anterograde direction. Does not have negative hypotensive properties. The inotropic effect of the drug in clinical practice was not noted. Automatism in the sinus node is not oppressed.

The degree of spasmolytic, local anesthetic, as well as cholinoblocking effect of Allapinin, according to reviews, has no clinical significance. Coronary dilatation and sedation are also insignificant. When taken orally, the effect begins in 40-60 minutes, reaching a maximum after 4-5 hours. The therapeutic effect lasts more than 8 hours. After intravenous administration of the drug, its antiarrhythmic effect is manifested after 15-20 minutes and lasts 6-8 hours, with a maximum after 2 hours.

Indications for use

The instructions to Allapinin indicated that this drug is intended for the treatment of the following diseases:

  • Ventricular extrasystole;
  • Paroxysmal supraventricular tachycardia, including those caused by WPW syndrome;
  • Nadzheludochkovoy extrasystole;
  • Paroxysmal ventricular tachycardia (provided there is no organic damage to the heart);
  • Paroxysms of scintillation and atrial flutter.


The intake of Allapinin is not possible with the following abnormalities or diseases:

  • various heart diseases, which are accompanied by a rhythm disturbance;
  • heart block, in which the hemodynamics of the heart is disturbed;
  • severe or chronic liver or kidney disease;
  • children under 18 years.

With extreme caution appoint patients with poor blood circulation. In this case, Allapinin appointed in a hospital, under the strict supervision of a doctor.

The drug is strictly prohibited for children and persons under the age of 18 years. There is no information about the effect of lappaconitin hydrobromide on children's body.

Application in pregnancy and lactation

Appointment of Аллаapinin during pregnancy is not recommended. Its reception is possible only for vital indications if the potential benefit to the mother substantially outweighs the risks to the fetus.

Information on the penetration of lappaconitin hydrobromide in breast milk is not available. Its use during lactation is not recommended. If treatment with Allapinin at this time is necessary, you should stop breastfeeding.

Instructions for use Allapinin

The instructions for use indicate that the tablets Allapinin, pre-chopped, taken inside 30 minutes before eating, washed down with warm water.

  • Initially, appoint , 25 g every 8 hours. In the absence of effect, the dose is increased, assigning to 0.025 g every 6 hours. It is possible to further increase the dose to 0.05 g per dose every 6-8 h. The duration of treatment depends on the patient's condition and the nature of the rhythm disturbance, can last up to several months. Higher doses inside: single dose - 0.05 g, daily - 0.3 g.

The beginning of the action when taken orally after a single dose - after 40-60 minutes, the maximum effect - after 4-5 hours, the total duration of action - more than 8 hours.

  1. Intramuscularly, allapinin is administered at a dose of 0.4 mg / kg every 6 hours.
  2. Intravenously, aallapinin is administered at a dose of 0.3-0.4 mg / kg. Before use, the drug is diluted to 20 ml with isotonic sodium chloride solution. Allapinin injected slowly - within 5 minutes. If necessary, after 6 hours, the administration of the drug at a dose of 0.3 mg / kg is repeated.

With intravenous administration, the action of the drug develops relatively slowly - after 15-20 minutes and reaches a maximum at 2 o'clock; the effect persists for up to 6-8 hours.

Side effects

Feedback from patients who have been treated with Allapinin indicate that this drug may have side effects such as:

  1. Violations of intraventricular and AV-conduction, sinus tachycardia, changes in ECG.
  2. Dizziness, a feeling of heaviness in the head, headache, diplopia, ataxia.

In the first days of treatment, it is possible to develop an arrhythmogenic action (increased arrhythmia or the appearance of a form that was not observed before).

Also, Allapinin, according to reviews, can cause hyperemia of the skin and allergic reactions.


Due to the fact that the drug has a small breadth of therapeutic activity, severe intoxication can develop quite easily. Especially the risk of poisoning is high when taking other antiarrhythmic medications. In case of overdose, the PR- and QT-intervals are lengthened, the amplitude of the T-wave increases, the QRS-complex is enlarged. On the background of intoxication, asystole, bradycardia occurs, myocardial contractility decreases.

The patient also has a sinotrial block, a decrease in pressure of a pronounced nature, a digestive system disorder. Intoxication is accompanied by paroxysms of ventricular polymorphic tachycardia, blurred vision, dizziness, headache. When an overdose occurs, symptomatic therapy is indicated. Treatment of ventricular tachycardia is carried out using antiarrhythmic drugs of category I A and I C. The expansion of the QRS complex, arterial hypotension and bradycardia are eliminated by sodium bicarbonate.

Drug Interactions

Inducers of microsomal liver enzymes reduce efficacy and increase the risk of toxic effects associated with the use of lappaconitin hydrobromide. With the combination of Allapinin with other antiarrhythmic drugs, the occurrence of arrhythmogenic action is more likely. This drug enhances the effect of nondepolarizing muscle relaxants.

special instructions

Before starting treatment with Allapinin, water-electrolyte exchange disorders should be eliminated, and during the therapy it is necessary to control the water-electrolyte balance.

When there is a long-term use of the preparation of sinus tachycardia, low doses of beta-blockers are necessary.

With the development of dizziness, headache, diplopia, it is necessary to reduce the dose of Allapinin.

When taking the drug, you must be careful, carrying out potentially dangerous activities that require increased attention and quick response.


On the Internet there are many reviews about Allapinin. In positive responses, people who take Allapin continuously or once, talk about high efficiency this drug to maintain the normal functioning of the heart, its rapid and long-lasting effect.

Quite often there are statements of people for whom there is no alternative to this medication according to the effect it produces. In negative reviews, the high price of the drug, its multiple contraindications and side effects are noted.


Allapinin does not have structural analogs for the active ingredient. Analogues for the pharmacological group (antiarrhythmics and blockers):

  • Adenocorus;
  • Amiodarone;
  • Amiocordin;
  • Asparks;
  • Atenolol;
  • Betacard;
  • Betaxalol;
  • Betalk;
  • Bidop;
  • Bisoprolol;
  • Bretilate;
  • Dinexan;
  • Diphenine;
  • Cardiodarone;
  • Kinidin Durules;
  • Concor;
  • Concor Cor;
  • Corvitol;
  • Cordarone;
  • Lappakonitina hydrobromide;
  • Lidocaine;
  • Lidocaine hydrochloride;
  • Metoprolol;
  • Multac;
  • Nebivolol;
  • Non-ticket;
  • Neo Giluritmal;
  • Nibentan;
  • Novocaineamide;
  • Opakorden;
  • Pamaton;
  • Panangin;
  • Panangin Forte;
  • Prokainami;
  • Propanorm;
  • Propaphenone;
  • Propranolol;
  • Profen;
  • Refralon;
  • Ritalmex;
  • Rhythmiodaron;
  • Rhythmodan;
  • Rhythm monm;
  • Sedacorone;
  • Sotagexal;
  • Sotalol;
  • Tenoric;
  • Trimecaine;
  • Trimecaine injection;
  • Egilok;
  • Egilok Retard;
  • Etatsizin;
  • Ethmosin.

Before using analogues, consult your doctor.

Storage conditions

The drug should be stored in a dark place, not accessible to children at a temperature of no more than 25 °.

The result

Reviews of the cardiologists about the drug as a whole are positive. It is really capable of removing symptoms and will improve the state of the cardiovascular system. However, he should be appointed only by a cardiologist.

If properly applied and monitored during the treatment for their condition and the occurrence of side effects, then allapinin significantly improve health, thereby making life easier for the patient.

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