Solution and tablets Desal: the instruction and responses of people

Dezal found application in the treatment of allergic reactions. It contains desloratadine, a selective inhibitor of histamine receptors.

Due to this action, oppression of the course of cytotoxic reactions, ejection of inflammatory mediators and as a consequence - blocking the development of edema of mucous membranes, migration of cells into mucous membranes and inflammations in them in allergic reactions.

On this page you will find all information about Desal: the full instruction on the application for this medicine, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Desal. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

The blocker of histamine H1 receptors. Anti-allergic drug.

Conditions of leave from pharmacies

Available without a prescription.

Price list

How much does Dezal cost? The average price in pharmacies is at the level of220 rubles.

Form of issue and composition

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The drug is available in twomedicinal forms:

Tablets in a special film membrane;
Solution for taking per os (preferably for children in view of ease of use).

1 tablet contains:

active substance: desloratadine - 5 mg;
auxiliary components: mannitol, microcrystalline cellulose, magnesium stearate, corn starch, pregelatinized starch, talc;
composition of the shell: opadray blue 03F20404 [titanium dioxide (E171), hypromellose 6cP, dye indigo carmine aluminum varnish (E132), macrogol 6000].

In 1 ml of the solution contains:

active substance: desloratadine - 0.5 mg;
auxiliary components: sorbitol, citric acid monohydrate, hypromellose 2910, propylene glycol, sodium citrate dihydrate, disodium edetate, tutti-frutti flavor, sucralose.

Pharmacological effect

An antihistamine long-acting drug, a blocker of peripheral H, -histamine receptors. Desloratadine is the primary active metabolite of loratadine.

Inhibits a cascade of reactions of allergic inflammation, incl. release of pro-inflammatory cytokines, including interleukins IL-4, IL-6, IL-8, IL-13, the release of pro-inflammatory chemokines, the production of superoxide anions by activated polymorphonuclear neutrophils, the adhesion and chemotaxis of eosinophils, isolation of adhesion molecules such as P-selectin, IgE-mediated release of histamine, prostaglandin D2 and leukotriene C4.

Thus, it prevents the development and alleviates the allergic reactions, possesses antipruritic and antiexudative action, reduces the permeability of capillaries, prevents the development of edema of tissues, spasm of smooth muscles.

The action of desloratadine begins within 30 minutes after ingestion and lasts for 24 hours.

Indications for use

What helps? The instruction for the preparation presupposes the following indications:

Itching itch;
Redness of the eyeballs, eyelids and increased lacrimation from the lacrimal ducts;
Idiopathic urticaria;
Acute bronchospasm;
Manifestation of a full-fledged rhinitis;
Stagnation in case of allergy;
Itching of the nasopharyngeal mucosa;
Manifestations of allergy symptoms of an unknown nature.

Contraindications

This drug can not be administered when:

breastfeeding;
children under 12 years (for tablets) and up to 1 year (for solution) (efficacy and safety not established);
pregnancy;
hypersensitivity to any substance of the drug.

It should also be noted that with special care, the agent in question is prescribed for renal failure (severe).

Application in pregnancy and lactation

Desal is not prescribed for the treatment of allergic reactions in women waiting for the birth of a child. This is due to the lack of reliable data on the safety of the effect of the main active ingredient of the drug on fetal development.

Since desloratadine can penetrate into breast milk, and then into the body of a child with food, the use of this medication during breastfeeding is contraindicated. If it is necessary to treat the drug Dezal a woman is recommended to interrupt lactation for a while and transfer the child to artificial feeding.

Instructions for use

The instructions for use indicate that Dezal is available in two dosage forms, for each of which the manufacturer has developed its own treatment regimen. About how many days you can take a medicine, you need to clarify with the doctor who prescribes the medicine.

1) Desala Tablets, instructions for use:

Tablets are taken orally.
Recommended dosing: 1 pc. 1 time a day, regardless of food intake.

2) Desal Solution, instructions for use:

The solution is intended for oral administration, once a day, regardless of food intake. Dosing has age limits:

patients older than 12 years: 10 ml each;
children aged 6-11 years: 5 ml each;
children aged 1-5 years: 2.5 ml each.

Side effects

Most often, the following undesirable reactions are noted: increased fatigue (1.2%), dryness of the oral mucosa (0.8%), headache (0.6%). When using the drug in adults and adolescents at the recommended dose of 5 mg / day, the incidence of drowsiness is not higher than with placebo.

During post-marketing surveillance, the following adverse reactions were very rarely observed:

Mental disturbances: hallucinations.
On the part of the digestive system: abdominal pain, nausea, vomiting, indigestion, diarrhea.
From the musculoskeletal system: myalgia.
From the side of the central nervous system: dizziness, drowsiness, insomnia, psychomotor hyperactivity.
From the cardiovascular system: tachycardia, a feeling of palpitations.
From the liver and bile ducts: increased activity of liver enzymes, increased bilirubin concentration, hepatitis.
Allergic reactions: anaphylaxis, angioedema, itching, rash, urticaria.

Overdose

According to reports of specialists, a drug taken at a dosage exceeding the recommended dose by 9 times did not lead to any side effects. However, in rare cases, patients developed drowsiness. As a treatment, gastric lavage is used. Also, the patient can be assigned to receive activated carbon.

special instructions

In the case of severe renal dysfunction, Dezal should be taken with caution.

In studies, no effect of desloratadine on vehicle management was noted. However, it should be taken into account that very rarely some patients develop drowsiness, in this case Care should be taken when driving vehicles and operating machinery.

Drug Interactions

Clinically significant interaction with other drugs has not been identified (including with ketoconazole and erythromycin).

Desloratadine does not enhance the effect of ethanol on the central nervous system.

Reviews

We picked up some of the people's comments about the Dezal drug:

Elena. Dezal perfectly helps, for example when biting insects. But with allergies and sneezing is not very. But the stomach he likes, from him he does not hurt at all. And suprastin, cetrine, deasaline cause pain.
Catherine. I also came up with an antihistamine drug "Dezal" from an allergy, before that I started to drink Citrine, it was even worse. I take it somewhere from May to September with interruptions, there were no side effects. The price is acceptable. And also I try to wash my hands more often, wash my nose and do not go to places where there is ambrosia.