Diclofenac injections: instructions for use

Diclofenac injections are a remedy intended for the removal of pain and consisting of para-hydroxybenzoic acid (NSAID) derivatives of phenylacetic, not related to the steroid group anelhetics.

Causes a protective-adaptive reaction of the organism, directed at eliminating the effect of the pathogenic stimulus and restoring the function of damaged organs. It has an obvious chemotherapeutic property with respect to diseases of local tissue damage. It is a nonselective inhibitor of the enzyme cyclooxygenase, which increases the sensitivity of nociceptive receptors to mediators of pain.

On this page you will find all information about Diclofenac: the full instructions for use for this medicine medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used injections Diclofenac. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

NSAID, a derivative of phenylacetic acid.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much are the ampoules of Diclofenac? The average price in pharmacies is at the level of36 rubles.

.

Form of issue and composition

For ease of use, Diclofenac is produced in a wide variety of dosage forms:

• tablets in an enteric shell (2, 0 mg);
• capsules of prolonged action (100 mg);
• rectal suppositories (50 and 100 mg);
• ointment Diclofenac (1% and 2%);
• gel Diclofenac (1% and 5%);
• Diclofenac injections in ampoules for intravenous administration;
• eye drops (,%).

Tablets of Diclofenac, as well as injections, are very helpful in rheumatic joints and diseases accompanied by severe pain syndrome. Local funds in the form of a gel and ointment are used for external treatment of inflammatory foci in order to eliminate puffiness and painful sensations. Eye drops Diclofenac is prescribed for the treatment of post-traumatic conditions.

Pharmacological effect

Diclofenac injections have such effects:

1. Anti-inflammatory;
2. Analgesic;
3. Antipyretic.

The explanation of the effectiveness of the active substance lies in the inhibitory effect on cyclooxygenase. In connection with it, the reactions of prostaglandin formation are inhibited. Also, the drug suppresses the platelet aggregation reaction. Diclofenac eliminates soreness, joint stiffness, restores their functionality. If it is necessary to use in cases of post-traumatic and post-operative complications, it helps to alleviate both spontaneous pain syndrome and pain during movement.

Indications for use

What helps? The appointment of diclofenac is justified in the following cases:

• ankylosing spondylitis (Bekhterev's disease);
• injuries of the musculoskeletal system;
• autoimmune connective tissue diseases;
• postoperative pain;
• inflammatory processes of joints and muscles, accompanied by pain syndrome;
• Rheumatism, including conditions, which are accompanied by simultaneous defeat of the organs of the musculoskeletal system;
• degenerative-dystrophic diseases of the organs of movement - arthrosis, osteoarthritis, osteochondrosis of the spine;
• Neuralgia accompanied by severe pain syndrome.

Contraindications

Diclofenac solution is contraindicated under the following conditions:

• violations of hematopoiesis;
• changes in hemostasis, including hemophilia;
• exacerbation of gastrointestinal lesions (erosive-ulcerative);
• bleeding from the digestive tract;
• children's age till 18 years;
• lactation;
• pregnancy;
• "Aspirin triad" - intolerance of NSAID drugs in patients with bronchial asthma and polyps in the nose;
• with intolerance of the main or auxiliary substances, as well as in the presence of hypersensitivity to other NSAIDs.

It is used with caution in the following conditions: bronchial asthma, anemia, congestive heart failure, edematous syndrome, arterial hypertension, hepatic or renal failure, inflammatory bowel disease, alcoholism, erosive and ulcerative diseases of the digestive tract chronic exacerbations), diabetes, diverticulitis, induced porphyria, condition after major surgical interventions, advanced age, systemic pathologies connective tissue.

Application in pregnancy and lactation

The use of Diclofenac is possible in the first and second trimesters of pregnancy strictly according to the indications and after the appointment of a doctor! The drug affects the development of the embryo and increases the risk of congenital malformations. Diclofenac is prescribed in a minimal amount and for a short period of time.

In the third trimester of pregnancy, the use of the drug may lead to severe hypoxia of the fetus and its death. In addition, diclofenac reduces the contractile capacity of the uterus, which is fraught with weakness of labor and postpartum hemorrhage.

Instructions for use

The instructions for use indicate that the appointment of diclofenac injections involves the technique of its especially administration. So, everyone who will inject it intramuscularly, it should be remembered that the solution of this drug should be inserted deep into the gluteus muscle, the uppermost part (upper outer quadrant buttocks).

Injections should alternate alternately in one and then in the other buttock. It is recommended to inject diclofenac injections warmed to body temperature. For this, the ampoule with the medicine should be warmed, holding it in the palm of your hand. Such warming will make the introduction of the drug more comfortable, will promote a faster action of the active components of the drug and allow more rapid anesthetization of the patient.

1. The recommended therapeutic dose of the drug is 75 mg (1 ampoule per day). The course of treatment should not last more than 2 days, if necessary, then switch to oral or rectal use of the drug.
2. In severe forms of the disease (for example, with colic), 2 injections of 75 mg can be given, with an interval of several hours (the second injection should be performed in the opposite gluteal region).
3. Alternatively: IM once a day (75 mg) can be combined with diclofenac in other dosage forms (tablets, rectal suppositories), while the total daily dose should not exceed 150 mg.
4. In migraine attacks: IM at a dose of 75 mg (at the beginning of an attack), if necessary, suppositories in a dose of up to 100 mg can be added on the same day if necessary. The total daily dose should not exceed 175 mg.

In diseases of the cardiovascular system (including with uncontrolled arterial hypertension) or high risk of cardiovascular disease Diclofenac should be used with a particular caution. If the course of treatment lasts more than 4 weeks, the drug should be used in a daily dose not exceeding 100 mg.

Side effects

Side effects of injections of Diclofenac can be divided into groups, as shown in the table below.

System of organs or group of symptoms	Side effects
Infectious diseases	In rare situations, the development of postinjection abscess is possible if the skin disinfection rule is not observed before injecting.
Hematopoietic system	Leukopenia and agranulocytosis, thrombocytopenia, aplastic and hemolytic variants of anemia.
Immunity system	Hypersensitivity, including anaphylactic shock, angioedema.
Nervous system	Headaches and dizziness, worsening of sleep, memory, disturbance of sensory, convulsive conditions, aseptic form of meningitis, strokes.
Mental disorders	Unreasonable anxiety attacks, irritation, depressive states, nightmares, disorientation in space.
Visual analyzer	Diplopia, blurred vision.
Hearing Aid Analyzer	Noises in the ears, hearing impairment.
The cardiovascular system	Arrhythmias, symptoms of heart failure, myocardial infarction, pain syndrome, increased blood pressure, vasculitis.
Respiratory system	Bronchial asthma, pneumonitis.
Gastrointestinal tract	Abdominal pain, vomiting and nausea, disruption of food digestion, swelling, diarrhea, gastritis, peptic ulcer, gastrointestinal bleeding. To rare negative consequences on the part of the digestive tract include glossitis and stomatitis, dysgeusia (a violation of taste), the formation of intestinal diaphragm-like structures, colitis, pancreatitis, constipation.
Liver and bile ducts	Hepatitis, worsening of the functional state of the liver, a jump in the activity of enzymes-transaminases in the blood.
Dermatological pathology	Eruption, dermatitis, erythema, eczema, Lyell and Stevens-Johnson syndromes, purpura, alopecia, photosensitivity.
Excretory system	Nephrotic syndrome, nephritis, proteinuria and hematuria, insufficient functionality of the kidneys.
General symptoms	Soreness and formation of compaction at the site of administration of the medication, less often - puffiness and necrotic changes at the injection site.

Overdose

With a slight excess of this daily allowable dose, the patient may have the following symptoms:

• nausea, vomiting, dizziness until loss of consciousness;
• convulsions;
• cardiopalmus;
• bleeding;
• pain in the epigastric region.

In the presence of an overdose, symptomatic treatment is carried out, implying:

1. Gastrointestinal tract flushing, which reduces the concentration of toxins;
2. The introduction of a large dose of any sorbent that binds and neutralizes toxins.
3. Ample drinking of boiled water at room temperature

special instructions

Before using Diclofenac, it is important to read its instructions. It is necessary to pay attention to a number of special instructions, which include:

1. With simultaneous use of other non-steroidal anti-inflammatory drugs, the dose of solution for injection of Diclofenac should be reduced.
2. The active substance of the drug inhibits the aggregation (adhesion) of platelets, so during the application of the solution for parenteral administration of Diclofenac requires a laboratory monitoring of the state of the hemostasis system (coagulation system of blood).
3. During the course of treatment, it is not recommended to perform work requiring increased concentration of attention or speed of psychomotor reactions.

Drug Interactions

Simultaneous application with:

• SCS or other NSAIDs - causes side reactions from the gastrointestinal tract;
• cyclosporine - increases the nephrotoxic effect of the latter;
• antidiabetic drugs - can provoke hyper- or hypoglycemia;
• methotrexate - may lead to increased concentrations and increased toxicity of the latter;
• hypotensive drugs and diuretics - reduces the effectiveness of these drugs;
• Acetylsalicylic acid - helps reduce serum concentration of diclofenac;
• potassium-sparing diuretics - leads to hyperkalemia;
• anticoagulants - requires regular monitoring of hemocoagulation;
• lithium preparations, phenytoin or digoxin - promotes an increase in plasma concentrations of these agents.

If there are indications, eye drops can be combined with other ophthalmic agents, in the composition of which includes the GCS (between instillations should be kept at least 5-minute break).

Consequences of alcohol with NSAIDs

The use of alcohol during the treatment of NSAIDs can cause:

• development of unpredictable complications and adverse reactions;
• impairment of liver function;
• decrease in the effectiveness of the drug;
• hypertension and, as a consequence, strengthening of stagnant phenomena in the circulatory system and intoxication of the body.

There are no injections and alcohol compatibility, because the injectable form of the drug stimulating the activity of the central nervous system, and alcohol, on the contrary, inhibits it. As a result, serious neurological abnormalities are possible.

Reviews

We picked up some feedback from people about Diclofenac injections:

1. Sergei. I have two intervertebral hernias permanently stitching diclofenac. I always hear from the treating doctors that it is harmful, they are already trying not to prescribe it. The harm is not explained. I tried various painkillers, and expensive ones as well. I do not know why, but only diclofenac acts on me. The price is generally ridiculous 55 rubles.
2. Anna. Though to me diclofenac in pricks pricked, the stomach began to hurt or be ill; be sick strongly. So the most interesting thing, then in a paid clinic they said that it does not need to be put at all in large numbers, but it is necessary to put an elbow, because it lits joints, and diclofenac simply removes inflammation.
3. Alexander. I got acquainted with dicolphenac because of one unexpected incident. I had to meet my niece early in the morning. He got up early, began to dress, but did not have time to pull the second leg of his trousers, as the wildest pain pierced him. Sweat rolled hail, but somehow dressed, his wife helped to sit behind the wheel, met. And in the morning in the clinic, a diagnosis, osteochondrosis. Have registered just nyxes of a diclofinac and though about it often goes bad glory, but he helped me literally on the fourth day to me on new even to serve myself. There may be many side effects, but nevertheless, with his task, he copes magnificently.
4. Oksana. For a long time I am excruciated from such unpleasant disease as gonarthrosis. Exacerbations occur regularly, 2-3 times a year, especially in the damp, spring-autumn period. At this time I suffer from excruciating pains in the joints. During another exacerbation rheumatologist prescribed Diclofenac. It is worth the drug is very inexpensive, the pharmacy is released freely. So, I felt relief on the second day after the beginning of treatment. The course took only 5 days. But the doctor warned that the repeated course can be passed no earlier than six months, since Diclofenac is capable of provoking a stomach ulcer with frequent use.

Most practitioners speak of Diclofenac as an effective and quick-acting medication. Meanwhile, cardiovascular risk in diclofenac is higher than that of its other "relatives" in the NSAID group. The shorter the course of treatment, the less likely the development of negative side effects. It is extremely important to follow the recommended dosages, take into account contraindications and do not resort to self-management without prescribing a doctor.

Analogues

If for any reason, there was no Diclofenac in the pharmacy or the patient has contraindications, such a drug can be replaced with a similar remedy.

Analogues of diclofenac are:

• Bioran;
• Ibuprofen;
• Voltaren;
• Diklak;
• Orthophene;
• Diklogen;
• Orthofer.

Before using analogues, consult your doctor.

Which is better: Diclofenac or Ibuprofen?

Preparations based on ibuprofen indiscriminately suppress COX. That is, having the same indications for use and contraindications, they provoke the same side effects.

Nevertheless, unlike its analogue, Ibuprofen is somewhat better tolerated by children and pregnant women, which makes it possible to use it (albeit with caution) in pediatrics and obstetric-gynecological practice.

Storage conditions and shelf life

The shelf life of the solution for parenteral administration of Diclofenac is 5 years. The drug should be stored out of reach of children at an air temperature of not more than + 25 ° C.

How to choose probiotics for the intestine: a list of drugs.

Effective and inexpensive cough syrups for children and adults.

Modern non-steroidal anti-inflammatory drugs.

Review of tablets from the increased pressure of the new generation.

Antiviral drugs are inexpensive and effective.