Cerucal

Cerucal is a drug with an antiemetic effect blocking dopamine receptors.

When applied, Cerucal has a mild antiemetic effect and promotes normalization of the digestive tract. The active drug substance selectively blocks dopamine and serotonin receptors, thereby impairing the passage of impulses through the brain receptors and decreasing the sensitivity of nerve cells, which are responsible for the transfer of pulses from the duodenum directly to the vomiting center, which is located in the medulla oblongata.

It is available in the form of intestinal-coated tablets and solution for intramuscular and intravenous administration.

Clinical and pharmacological group

Antiemetic drug of central action, blocking dopamine receptors.

Terms of sale from pharmacies

Can buyby prescription.

Price

How many hundred tablets are Cerucal in pharmacies? The average price is at the level of125 rubles.

Composition and form of release

Cerucal is available in the following dosage forms:

tablets: flat, round, white, with a risk on one side (50 tablets in a bottle of brown glass, 1 bottle in a cardboard box);
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solution for intramuscular and intravenous administration: a clear colorless liquid (2 ml of solution in an ampoule of transparent glass, 5 ampoules in an open contour cell, 2 contour mesh packages in a cardboard box).

Composition of 1 tablet:

active ingredient: metoclopramide hydrochloride monohydrate - 10.54 mg (metoclopramide hydrochloride - 10 mg);
auxiliary components: lactose monohydrate, potato starch, silicon dioxide, gelatin, magnesium stearate.

Composition of 1 ml of solution:

active ingredient: metoclopramide hydrochloride monohydrate - 5.27 mg (metoclopramide hydrochloride - 5 mg);
auxiliary components: sodium chloride, edetate disodium, sodium sulphite, water for injection.

What to prefer - pills or injections?

Tablets and injections of Cerucal are used to achieve the same therapeutic effects associated with the need to stop vomiting and accelerate the movement of food through the stomach and intestines.

Tablets are preferred in those cases where a relatively long therapeutic effect is required, since their action lasts for 5.5 to 6 hours. As a rule, this is a complex therapy of various chronic diseases of the digestive tract, in which the progress of food a lump in the intestines and stomach, resulting in symptoms of dyspepsia (heartburn, flatulence, heaviness in the stomach, etc.). Usually Cerucal is used in the complex therapy of reflux-esophagitis, gastritis, peptic ulcer of the stomach and duodenum, stenosis of the pylorus and dyskinesia of the biliary tract, in which food stagnates in the stomach and intestines, causing unpleasant symptoms.

When vomiting, hiccups and nausea, the choice between pills and injections is made on the basis of a person's ability to take the drug inside. In other words, if a person can swallow a pill and do not tear for 15-20 minutes afterwards, then this particular form of the drug should be chosen. And only in case of impossibility to take Cerukal in tablets for relief of vomiting, hiccups and nausea should be used nyxes. However, at the first opportunity, Tserukal injections should be replaced with tablets.

With diabetic gastroparesis, ideally in the morning after breakfast, enter Cerucal intramuscularly, and for the rest of the day - take in tablets.

For diagnostic manipulation, such as duodenal sounding, small intestine and stomach x-ray, intravenous or intramuscular the introduction of the solution of Cerukal, since in this case its effect comes quickly and lasts for a short period of time (no more than 2 hours), which is very convenient. With the injection of Cerucal, the stomach and intestines are released from the food lump, the introduction is facilitated probe and contrast medium, which provides optimal conditions for qualitative diagnosis. Moreover, these effects do not last long and, therefore, do not cause a person anxiety after the completion of the procedure.

For children older than 14 years, you can follow the recommendations described above on the choice of the dosage form of Cerucal. Children aged 2 to 14 years should use Cerucal exclusively in the form of injections, since the solution allows for accurate dosage of the drug.

Pharmacological effect

Cerucal - antiemetic, which helps reduce nausea, hiccups; stimulates the peristalsis of the gastrointestinal tract. Antiemetic effect is due to blockade of dopamine D2 receptors and an increase in the threshold of chemoreceptors in the trigger zone. Metoclopramide inhibits the relaxation of the smooth muscles of the stomach, thereby strengthening cholinergic reactions of the smooth muscles of the gastrointestinal tract.

Helps to accelerate the emptying of the stomach by, preventing relaxation of the body of the stomach and increasing the activity of the antrum of the stomach and upper parts of the small intestine. Reduces reflux into the esophagus by increasing the pressure of the sphincter of the esophagus at rest and increases the clearance of acid from the esophagus.

Indications for use

What helps? Indications for the reception of Cerucal:

Flatulence, reflux esophagitis, biliary dyskinesia, functional stenosis of the pylorus.
Conduction of duodenal sounding (to accelerate the emptying of the stomach and move food through the small intestine).
Strengthening of peristalsis during radiocontrast studies of the digestive tract.
Attacks of nausea and vomiting, hiccough of different genesis.
Hypotension and atony of the intestine and stomach (in particular, postoperative).
Diabetic gastroparesis.
Paresis of the stomach in patients with diabetes mellitus.
Exacerbation of gastric ulcer and duodenal ulcer (as part of complex therapy).

Contraindications

Cerucal is not prescribed for bleeding in the digestive system, with intolerance to metoclopramide, pheochromocytoma, perforation of the intestine and stomach, mechanical intestinal obstruction, stenosis of the pylorus of the stomach, epilepsy, extrapyramidal disorders, with prolactin-dependent tumors, Parkinson's disease. With arterial hypertension, bronchial asthma, kidney pathology, liver, in pediatrics appoint with caution.

Intended use for pregnancy and lactation

In very rare cases, Cerukal can be prescribed to pregnant women, but only when his reception does not threaten the fetus and the pregnant woman herself.

Dosage and route of administration

As indicated in the instructions for the use of the tablet Cerucal taken inside 30 minutes before meals three times a day for 5-10 mg. It is recommended to take a tablet with a large amount of liquid. The maximum daily dose of 60 mg, single 20 mg.

Prick Cerulek, instructions for use:

Adults and at the age of 14 years enter intramuscularly or slowly intravenously, one ampoule 1-3 per day.

Children from 2 to 14 years of age should be injected at a rate of 0.1 mg / kg, the maximum allowable dose per day is 0.5 mg / kg.

Adverse Reactions

During treatment with Cerucal tablets, the patient may experience side effects:

from the gastrointestinal tract - dry mouth, heartburn, belching, a feeling of heaviness in the stomach, constipation, bloating, increased gas production;
from the nervous system - dizziness, insomnia, a sense of fatigue, lethargy, apathy, unreasonable feeling of fear, noise in the ears, twitching of the muscles of the face, spasm of the facial musculature, tremor of the limbs;
from the side of the cardiovascular system - changes in blood pressure indicators, tachycardia;
on the part of the endocrine system - galactorrhea in women (discharge of colostrum from the breast, not associated with lactation), gynecomastia, menstrual irregularities, erectile dysfunction.

With the development of one or more of the described side effects, treatment with the drug is canceled and consulted by a doctor.

Overdose Symptoms

In reviews about Tserukal it is reported that when an overdose of the drug observed confusion, irritability, convulsions, bradycardia, hyperkinesis, extrapyramidal disorders, arterial hypotension or hypertension. Treatment is symptomatic.

special instructions

Before you start using the drug, read the special instructions:

During the treatment should refrain from drinking alcohol.
Children and adolescents from 2 to 14 years with the goal of correct dosing the drug is prescribed only in the form of injections.
In adolescents and patients with severe impairment of kidney function, there is an increased risk of side effects.
Against the background of the use of metoclopramide, there are possible distortions of these laboratory parameters of liver function and determination of the concentration of aldosterone and prolactin in plasma.

During the treatment period it is necessary to refrain from driving motor vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Compatibility with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

Anticholinergics can weaken the action of metoclopramide.
Metoclopramide decreases the effectiveness of pergolide, levodopa.
Metoclopramide increases the bioavailability of cyclosporine, which may require monitoring of its concentration.
Metoclopramide increases the concentration of bromocriptine in plasma.
Metoclopramide enhances the absorption of antibiotics (tetracycline, ampicillin), paracetamol, levodopa, lithium and alcohol.
Metoclopramide reduces the absorption of digoxin and cimetidine.
Metoclopramide enhances the effect of alcohol and drugs that depress the central nervous system.
Neuroleptic drugs with concomitant administration with metoclopramide may increase the risk of developing extrapyramidal disorders.
Metoclopramide increases the risk of hepatotoxicity when combined with hepatotoxic agents.

Patient Reviews

We offer you to read reviews of people who used Cerucal:

Anna. Very scary drug! Do not let children! It is very difficult to properly divide the pill! When an overdose causes convulsions, loss of consciousness, shortness of breath! The ambulance does not know what to give as an antidote.
Ivan. Personally, cerulek does not help at all. I really do not know what this is connected with. It turned out that when the doctor prescribed this drug for poisoning, in general, I perepil I little. After a shot intramuscularly to me it became better not, have told or said to wait polchasika. There was no effect, only a puncture was done in vain. My mother, on the contrary, except cerulekal does not help with vomiting. Apparently, also an individual feature. So it's impossible to judge too severely, all people perceive differently even universal medicines.
Nikolai. Because of the illness, I had to take cytotoxic drugs, but their use has many side effects. I had nausea, vomiting, a headache. With the first two symptoms successfully cured Tserukal, however, his head hurt even more, but I was patient. To me did droppers with a solution of a preparation - repeated every 2-3 hours.

Analogues

Structural analogs for the active substance:

Apo-Metoclop;
Metamol;
Metoclopramide;
Metoclopramide-Acry;
Metoclopramide-Vial;
Metoclopramide-Promed;
Metoclopramide-ESCOM;
Perinorm;
Raglan;
Ceruglan.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Keep the tablets out of reach of children, away from sunlight. Optimum storage temperature should not exceed 25 degrees. The shelf life of the tablets is indicated on the package and is 5 years from the date of manufacture.

Do not take the pills inside after the expiration date.