Danzil drops

Danzil is a medicinal product, which is presented in the form of drops.

Can be used to treat diseases of the eyes and ears. Has a pronounced antimicrobial effect. In the role of the active ingredient is ofloxacin. It belongs to the group of fluoroquinols. The drug is characterized by a wide degree of influence, which can successfully cope with gram-positive and gram-negative bacteria.

On this page you will find all information about Danzil: the full instruction on the application to this medicinal medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied drops of Danzil. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antimicrobial agent of the group of fluoroquinolones of wide spectrum of action.

Conditions of leave from pharmacies

Available without a prescription.

Price list

How much is Danzil? The average price in pharmacies is at the level of160 rubles.

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Form of issue and composition

Composition 1 ml of drops:

• active substance: ofloxacin - 3 mg;
• auxiliary components: benzalkonium chloride mg; sodium chloride 8 mg; edetate disodium - 1 mg; hypromellose - 2 mg; sodium hydroxide - in sufficient quantity; hydrochloric acid - in sufficient quantity; water for injection - up to 1 ml.

The form of the release of Danzila is a drop of the ear and eye: light yellowish, transparent (5 ml each in plastic bottles-droppers with screwed-on cap, or in a plastic bottle sealed with a stopper-dropper; in a cardboard bundle 1 bottle or a vial or flask-dropper).

Pharmacological effect

Dancil belongs to the group of antimicrobial antibiotics of fluoroquinolones. The mechanism of its action is associated with an effect on the enzyme called DNA-gyrase, which normally ensures the stability of the DNA of the pathogen by means of supercoiling. As a result of destabilization of the genetic material of bacteria, their death occurs, that is, the medicine has a bactericidal effect.

Ofloxacin is not sensitive to the action of certain enzymes released by bacteria. These include beta-lactamases, adenylases, acetyltransferases, phosphorylases. Ofloxacin is a synthetic preparation that is a fluorinated quinolone. It has a wide spectrum of action and is effective against gram-negative microorganisms. On Gram-positive bacteria it acts to a lesser extent.

Ofloxacin is active against most of the strains listed below: Chlamydia trachomatis; Haemophilus influenzae; Enterobacter cloacae; Proteus mirabilis; Staphylococcus aureus; Pseudomonas aeruginosa; Streptococcus pneumoniae.

Indications for use

What helps Danzil? These are infectious and inflammatory diseases caused by microorganisms sensitive to ofloxacin, including: diseases of the lower respiratory tract, ear, throat, nose, skin, soft tissues, bones, joints, infectious and inflammatory diseases of the abdominal organs (except for bacterial enteritis) and small pelvis, infection of the kidneys and urinary tract, prostatitis, gonorrhea.

Contraindications

Contraindications to admission:

1. Intolerance of the components of Dancyl.
2. Epilepsy.
3. Non-bacterial otitis media.
4. Violation of the functions of the central nervous system.
5. Fetching a child.
6. Breast-feeding.
7. Age to one year (with ocular pathologies).
8. Adolescence (with ear ailments).

Application in pregnancy and lactation

Fluoroquinolones are contraindicated in pregnancy, as they have an embryotoxic effect.

Despite the fact that the drug is used topically and is unlikely to penetrate the placental barrier, doctors do not recommend risking the health of the future baby and advise if necessary to choose a safer alternative.

The drug can be found in breast milk in trace concentrations, so during treatment it is necessary to stop breastfeeding.

Instructions for use

The instructions for use indicate that drops of Danzyl are buried in the ear or eye.

The recommended dosing regimen for adults and children from 12 years:

1. Otitis externa: 1 time per day - 10 drops per diseased ear. Course - one week.
2. Acute otitis media: 5 drops - 2 times a day. Course - 10 days.
3. Purulent otitis media with a ruptured eardrum: 10 drops - 2 times a day. Course - two weeks.
4. Before instillation the bottle should be slightly heated in the hand. A cold solution that gets into your ear can cause dizziness.

The recommended dosing regimen for adults and children from 12 years:

1. Bacterial corneal ulcer: The first two days in an infected eye drop 2 drops every half hour. During sleep - after 4-6 hours. From the third day, breaks are increased to four times a day.
2. With conjunctivitis, blepharitis, dacryocystitis, for the prevention of postoperative inflammations, droplets are applied at the beginning of therapy, 2 drops every 2-4 hours. Gradually, the dose is cut in half.

Side effects

When using drops in the ears, the following side effects are possible:

1. Painful sensations in the torn membrane.
2. Cod feel in the ears.
3. Temporary loss of sensitivity of sounds.
4. Itching and burning.
5. Allergic reactions.

Overdose

With prolonged use of drops, it is possible to get used to the organism and, as a consequence, to overdose drops. Sensitivity of the body will be lost. Therefore, do not use the drug for longer than the prescribed course of treatment. In special cases it is recommended to use analogues of the drug.

special instructions

1. When using ofloxacin should provide sufficient hydration of the body, the patient should not be exposed to ultraviolet radiation.
2. In experimental studies, a mutagenic potential was not detected. Long-term studies to determine the carcinogenicity of ofloxacin were not performed.
3. During the period of treatment, it is required to monitor blood glucose levels. With prolonged therapy, it is necessary to periodically monitor the functions of the kidneys, liver, and the picture of peripheral blood.
4. In studies on young animals of several species ofloxacin caused arthropathy and osteochondrosis.

Drug Interactions

1. With the simultaneous use of ofloxacin and NSAIDs, the risk of developing a stimulating effect on the central nervous system and seizures increases.
2. With the simultaneous use of ofloxacin with beta-lactam antibiotics, aminoglycosides and metronidazole, additive interaction is noted.
3. With simultaneous application with theophylline it is possible to increase its concentration in the blood plasma (including in the equilibrium state), an increase in T1 / 2. This increases the risk of adverse reactions associated with the action of theophylline.
4. When used simultaneously with antacids containing calcium, magnesium or aluminum, with sucralfate, with preparations containing two- and trivalent cations, such as iron, or with multivitamins containing zinc, there may be a disruption in the absorption of quinolones, leading to a decrease in their concentration in organism. These drugs should not be used within 2 hours before or within 2 hours after taking ofloxacin.

Reviews

We picked up some feedback from people about the drug Danzil:

1. Anna. I use the ear drops of Danzil for the first time. The main advantage of the drug remains a rapid therapeutic effect and an acceptable cost. As soon as autumn or spring comes, I immediately suffer from a cold. My pharyngitis is exacerbated by otitis. The doctor prescribed drops of Danzil to me. What surprised me about him was his versatility, because it can be used both to treat diseases of the ears and eyes. Painful sensations in the ears can not be called pleasant. But as soon as I began to drip the drops, the pain subsided the next day.
2. Diana. Assigned for sinusitis and tubootitis. There were pains in the ear and such stuffiness of his, that did not hear anything. Already after the first time of application the nausea disappeared and hearing was restored.
3. Marina. The drug in question in our large family is in great demand. For example, my uncle uses them in the treatment of conjunctivitis. He works all the time in a draft, so he often has problems with gases. But it is worth it to drip Danzil, as the condition is improving, and unpleasant symptoms go away. The drug helped me when I radiated otitis externa. I applied drops on a standard schedule during the day, but at night I put a cotton swab in my ear, treated in solution. In the first days of the illness, I had a terrible pain, but after using the drops, I could forget about it. And the process of recovery began to go much faster. I am very pleased with the effect of the medicine, so I decided to buy it and put it in our medicine chest.

Analogues

Analogues of the drug Danzil for pharmacological action are: Zofloks, Glaufos, Zanotsin, Unifloks, Floxal, Tarivid, Taricin, Oflotsid, Ofloksin, Oflomak, Ofloxacin Teva, Oflolxabol, Ofloks, Ofloxacin DS, Oflo.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Dancil is recommended to store in a cool, dark room at a temperature of no higher than 25 ° C. The drug is prohibited from freezing.

Shelf life of Danzila is 2 years. After opening, use the remedy for 30 days. After the expiration of the storage period, the product must be disposed of.

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