Nasobek

Nasobek is a synthetic glucocorticosteroid (SCS) for topical application of antiallergic, anti-inflammatory and immunosuppressive actions.

The main active substance of the pharmacological preparation is beclomethasone dipropinate. It is allowed to use Nasobek both for seasonal and all-year-round allergies.

In addition to anti-allergic anti-inflammatory local effect on the human body and removes the swelling of the mucous membrane of the nasal cavity.

Clinical and pharmacological group

GCS for intranasal administration.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Nasobek in pharmacies? The average price in 2018 is at the level of200 rubles.

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Form of issue and composition

Nasobek is produced in the form of a dosed nasal spray, which is a white opaque suspension that does not have visible foreign impurities (200 doses in plastic bottles with a mechanical dispensing applicator, in a cardboard bundle 1 bottle).

• Active substance: beclomethasone dipropionate - 50 mcg in 1 dose of spray.

Auxiliary components: 50% benzalkonium chloride solution, polysorbate 80, dispersive cellulose (carmellose sodium + microcrystalline cellulose), phenylethanol, 35% hydrochloric acid, dextrose anhydrous, purified water.

Pharmacological effect

Nasobek has anti-inflammatory, anti-allergic and immunosuppressive effects. Increases the production of lipomodulin, which is an inhibitor of phospholipase A, inhibits the release of arachidonic acid.

Prevents the accumulation of neutrophils, reduces inflammatory exudation and production of lymphokines, inhibits migration of macrophages, reduces the intensity of infiltration and granulation processes, the formation of a substance chemotaxis. Reduces the swelling of the nasal mucosa, the production of mucus. Improves mucociliary transport.

Indications for use

According to the instructions attached to Nasobek, the drug is indicated for use in the treatment and prevention of year-round and seasonal allergic rhinitis, as well as vasomotor (caused by nasal vegetative-vascular dysfunctions) rhinitis.

Contraindications

These include:

1. Tuberculosis;
2. Children under 6 years;
3. Viruses or fungi in the anamnesis, which actively multiply in the body;
4. Allergic reactions or intolerance of any of the components in the composition of the drug;
5. Diathesis with a tendency to hemorrhage;
6. 1 trimester of bearing a fruit;
7. Propensity to hemorrhages, nosebleeds, fragility of capillaries.

With care, the medication is prescribed for:

1. Glaucoma;
2. Cuts, ulcers and any damage to the nasopharynx;
3. Second and third trimesters during gestation;
4. After surgery in the nasal cavity or after a recent nasopharynx injury;
5. Hypothyroidism and iodine deficiency;
6. Myocardial infarction, recently transferred;
7. Breastfeeding;
8. Severe liver damage and amebiasis.

Use in pregnancy and lactation

The use of the drug Zaberok is contraindicated in the first trimester of pregnancy. Use of the drug Zaberok in the II and III trimesters of pregnancy is allowed only if the expected benefit for the mother exceeds the possible risk to the fetus.

Use Nasobek during breastfeeding should be done with caution.

Dosage and route of administration

The instructions for use indicate that Nasobek is used intranasally.

1. Children aged 6 to 12 yearsprescribe in the initial dose of 50 mcg (1 dose) in each nasal passage 2 times / day, if necessary - 100 mkg (2 doses) in each nasal passage 2 times / day. The maximum daily dose is 400 mcg. The daily dose can be divided into 2-4 admission.
2. Adults and children over 12 years of ageappoint 50-100 mcg (1-2 doses) in each nasal passage 2 times / day; The daily dose is 200-400 μg. The maximum daily dose is 400 mcg. The daily dose can be divided into 2-4 admission.

When the therapeutic effect is achieved, the drug is canceled, gradually reducing the dose.

Older patients do not need a dose adjustment.

Terms of use

At the first application it is necessary to unlock the spraying mechanism: press the dispenser several times until the aerosol cloud appears. If the drug has not been used for several days, the spraying mechanism must be unlocked again.

1. Clear the nasal passages;
2. Shake the vial, then remove the cap;
3. Place the bottle in the palm so that its bottom rests on the thumb, and the middle and index fingers rest on both opposite sides of the lower part of the nose applicator;
4. Press the dispenser several times until an aerosol cloud appears (this procedure is mandatory make before the first use and repeat in cases of prolonged interruption in use preparation);
5. Make an easy exhalation through the nose;
6. To pinch the nasal passage in which the injection of the preparation will not be made;
7. Insert the applicator into the free nostril;
8. Slightly tilt the head so that the bottle is in a perpendicular position;
9. Introduce the dose of aerosol by pressing the applicator and simultaneously inhaling slightly with an open nasal passage;
10. Exhale through the mouth;
11. If necessary, enter the second dose as described;
12. Repeat the same procedure from the second nostril;
13. Clean the upper (terminal) part of the applicator with a clean cloth and close with a cap.

The nasal applicator should be cleaned at least once a week in order to prevent the possibility of its clogging. To do this, lightly press the lower part of the applicator and detach the nasal applicator. Applicator and cap wash with warm water and allow to dry. After that, the applicator and the cap should be put back on the vial.

Side effects

During the application of Nasobek, the following side effects may develop (≥10% - very often; ≥1% and 0 0% - often; ≥,%; and l% - infrequent; ≥1% and ≤1% rarely; & l;, 01% - very rarely, incl. isolated cases; with an unknown frequency - if there is insufficient data necessary to assess the frequency of the development of violations):

1. Allergic reactions: rarely - hives, skin rashes, angioedema;
2. Nervous system: rarely - dizziness, drowsiness, impaired taste and smell, headache;
3. Body of vision: with unknown frequency - congestion hyperemia, increased intraocular pressure, including glaucoma, cataract (with prolonged therapy), decreased vision;
4. Respiratory system: rarely - sneezing, irritation and dryness of the nasopharynx, burning, rhinorrhea, nasal congestion, atrophy of the nasal mucosa, nosebleed, cough; very rarely - perforation of the nasal septum (usually in patients who had previously undergone surgical intervention in the nasal cavity), ulceration of the mucosa nose;
5. Other: rarely - myalgia, candidiasis of the upper respiratory tract and oral cavity (with prolonged therapy and / or use in high doses (more, mg per day); unknown frequency - with prolonged therapy, it is possible to reduce the rate of growth in children, the development of adrenal insufficiency, a decrease in mineral density bones.

Overdose

Symptoms: with prolonged use in high doses, as well as with the simultaneous administration of other (systemic) GCS, symptoms of hypercorticism may appear.

Treatment: the drug should be discontinued, gradually reducing the dose.

special instructions

Before you start using the drug, read the special instructions:

1. With prolonged use of Nasobek preparation in children, it is necessary to control the dynamics of their growth.
2. Patients with a high risk of developing adrenocortical insufficiency need control of the doctor.
3. Patients should be warned about the need to be careful and not to get into the eyes of the drug Nasobek.
4. The therapeutic effect of Nasobek, unlike local vasoconstrictors for the treatment of rhinitis, with intranasal application is not immediately apparent. Relief of symptoms of rhinitis usually becomes noticeable after 5-7 days from the beginning of application of the drug. When the therapeutic effect is achieved, the dose of the drug must be reduced to the minimum effective dose that controls the course of the disease.
5. Benzalkonium chloride, contained in the drug Zabobek, with prolonged use increases the risk of edema of the nasal mucosa. If such a reaction arises, correction of the dose of Nasobek or the use of a preparation containing no benzalkonium chloride is necessary.
6. Since the drug slows wound healing, patients with ulceration of the nasal septum, after surgical interventions in the nasal cavity, nose injuries, should not use the Nasobek preparation until the wounds are completely will heal.

In connection with the fact that with the use of the preparation Nasobek can develop drowsiness and dizziness, patients should be careful when transport management and occupations of potentially hazardous activities requiring increased concentration and speed of psychomotor reactions.

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

1. When combined, methandrostenolone, estrogens, beta2-adrenomimetics, theophylline, GCS for oral administration enhance the action of beclomethasone.
2. With the joint application of Nasobek increases the effect of beta-adrenomimetics.
3. When combined, phenobarbital, phenytoin, rifampicin reduce the effectiveness of beclomethasone (induction of microsomal oxidation enzymes).

Reviews

We picked up some reviews of people who used the drug Zabobek:

1. Anatoly. All will, ochu will share what helped me for more than 30 years suffer rennet nose without drops could not live did two operations promised the nose will breathe but it did not help for a long time now from frequent vospoleniy Polycystosis formed and I was helped by the drug Aldecin spray production Belgium removes the swelling and inflammation, three days later comes recovery, better helps than pump, it's more than a soup, about now I can not find it, nowhere else in pharmacies does the analogue eat, I want a proven drug, which really helps.
2. Oksana. The doctor prescribed it to me, when all possible means for getting rid of the cold were already tried. In the course of six months she suffered from a runny nose, as a result she was diagnosed with a vasomotor rhinitis. The drug is hormonal, anti-inflammatory, removes the mucosal edema. The effect of the spray was felt for 2 weeks of use. I did not observe any side effects of the drug, I did not get used to the spray. The price is within 200 rubles.
3. Anton. For more than a year I suffered from stuffy nose. Only vasoconstrictive agents such as galazoline were helpful. Antiallergic agents in tablets, as well as cromohexal, etc. had no success. After two days of application pasubeka felt relief, and on the fifth day he breathed freely both during the day and at night. Has passed or has taken place three weeks, I use a nosabee every day, in the morning and in the evening, and I am afraid to stop. The instructions say that when the therapeutic effect is achieved, the drug is gradually canceled. Well, then. I will cancel. Let's see if his actions last for long ...

Analogues

Analogs of Nasobek are such medications:

• Beclomethasone;
• Beklazone;
• Aldecin.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Store the drug should be at a temperature of 10 to 25 ° C, inaccessible place for children. The shelf life of the spray from the date of release is 4 years, if the vial has already been opened, the drug is allowed to use no more than 3 months.

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