Pentoxifylline

Pentoxifylline is a peripheral vasodilator, a derivative of dimethylxanthine.

It is a modern and effective remedy that improves the rheological properties of blood. The drug has a pronounced vasodilating and capillaroprotective effect, and also increases the resistance of capillaries and improves microcirculation.

The drug affects all types of blood vessels of the human body: arterial, venous, capillary. Admission Pentoxifylline allows to improve the tone of the respiratory muscles, to stop the processes of thrombus formation.

It is available in the form of tablets and a solution for intravenous and intra-arterial administration. The treatment regimen and the dose of the drug are set individually.

Clinical and pharmacological group

A drug that improves microcirculation. Angioprotector.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Pentoxifylline in pharmacies? The average price is at the level of100 rubles.

Form of issue and composition

The drug Pentoxifylline is available in the form of tablets coated with a protective film coat of pink color, which subsequently dissolves in the intestine.

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Active substance Pentoxifylline. Tablets contain 100 and 400 mg of this substance.

Tablets are packed in blisters of 10 pieces in a cardboard bundle, a detailed instruction with a description is attached to the preparation.

Pharmacological effect

A medicinal preparation that improves blood circulation and exerts a protective effect on the vascular wall by reducing the viscosity of the blood, increase the elasticity of red blood cells, vasodilator action and reduce the ability of platelets to form complexes.

During the use of Pentoxifylline, patients have a general improvement in the condition of internal organs and tissues due to an increase in the volume of incoming blood and the level of oxygen. In addition, there is an improvement in bioelectric processes in the brain and restoration of blood circulation in sites with impairments.

Pentoxifylline is absorbed well. Its neutralization takes place in the liver, excretion of the products of disintegration - with urine and feces.

Indications for use

Pentoxifylline is a very effective medicine in the treatment of many diseases and complications. His appointment helps with such ailments as:

arterial hypertension;
urolithiasis disease;
trophic ulcer;
muscular dystrophy;
spasms of smooth muscles;
cholecystitis;
cerebrovascular insufficiency;
ischemic stroke;
atherosclerotic encephalopathy;
bronchial asthma;
violations of the functions of the inner and middle ear;
encephalopathy;
impaired circulation of the eyes;
algodismenorea.

Application in sports

A characteristic drug is often used in bodybuilding to achieve the effect of pumping. After penetration of the initial dose of 200 mg Pentoxifylline into the body, the blood intensifies its circulation, which is especially important for trophic tissue disorders, acute oxygen deficiency.

Muscles receive an additional charge, and, due to increased blood flow, training is considered as productive as possible. Blood at an accelerated pace flows through the arteries, selectively stimulates the work of internal organs, so the action of a characteristic medicine reminds of Viagra.

Contraindications

Pentoxifylline is not an exception among other medicines due to the presence of certain contraindications. First of all, this pharmacological agent can not be used in the treatment of any disease, if the patient has an individual drug intolerance.

The medicine is contraindicated in the presence of such diseases as:

arrhythmia;
bleeding;
hemorrhage in the retina of the eye;
acute myocardial infarction;
pronounced atherosclerosis of the arteries of the brain;
hemorrhagic stroke;
low blood pressure;
lactation.

To prevent possible bleeding, the drug Pentoxifylline is not assigned to the operated patient or is administered with extreme caution under medical supervision.

You should not take the medicine if you have a patient with an erosive form of gastritis, stomach ulcer, kidney and liver diseases.

Use in pregnancy and lactation

It is known that any drug is allowed to be taken during pregnancy only if it passes special control for safety for the mother and fetus. Such control Pentoxifylline did not pass, therefore in all instructions it is indicated that it is contraindicated in pregnancy.

Data on the ability to isolate the drug with breast milk are not provided, so if necessary therapy a woman should decide on the completion of lactation, so as not to expose the child to unjustified risk.

Dosage and route of administration

The instructions for use indicate that the duration of treatment and the dosage regimen Pentoxifylline are prescribed by the treating physician individually, depending on the clinical picture of the disease and the resulting therapeutic effect.

The drug is taken orally right after eating, without chewing, squeezed with enough liquid.
Adults prescribe the drug, starting with 200 mg 3 times / day.

Prolonged dosage forms are prescribed 2 times / day. The course of treatment is 2-3 weeks or more.

Side effects

Among the most common side effects can be identified as follows:

thrombocytopenia, leukopenia;
accommodation, visual impairment;
dizziness, anxiety, sleep disturbances, convulsions, mood changes, headache;
exacerbation of cholecystitis, increased activity of liver transaminases, development of cholestatic hepatitis;
vomiting, a feeling of overflow in the stomach, nausea, diarrhea, decreased appetite;
urticaria, anaphylactic shock, itching, angioedema, redness of the facial skin;
the occurrence of arrhythmia, pain in the heart, lowering blood pressure, angina pectoris;
exacerbation of bronchial asthma, bronchospasm, respiratory failure;
bleeding of different etiology.

Overdose

In the case of a severe drug overdose, reactions such as nausea, vomiting, arrhythmia, severe headaches, tachycardia, chills, convulsions, the appearance of allergic reactions and others.

Treatment: symptomatic. The stomach is washed, activated charcoal is prescribed. The patient should be given a horizontal position with raised legs. The specific antidote is unknown. Monitor vital functions and general measures aimed at their maintenance, monitor the airway patency; when cramps are administered diazepam.

special instructions

Before you start using the drug, read the special instructions:

In cases of hemorrhage into the retina of the eye, treatment is immediately withdrawn.
With chronic heart failure before the start of the course, blood circulation compensation should be achieved.
In smoking patients, the therapeutic efficacy of Pentoxifylline may be reduced.
When combined with anticoagulants, you need to carefully monitor the parameters of the blood coagulation system.
Compatibility Pentoxifylline with infusion solutions must be checked individually.
Patients with severe impairment of renal function need careful monitoring of the condition.
After the recent surgical interventions, the level of hemoglobin and hematocrit should be systematically monitored.
Patients in old age in some cases, the drug is prescribed in reduced doses (associated with a decrease in the rate of excretion of the active substance and increased bioavailability).
Therapy, especially the intra-arterial and intravenous administration of Pentoxifylline, should be carried out under the control of blood pressure. Patients with unstable or low blood pressure injected dose is reduced.
The administration of Pentoxifylline in large doses to patients with diabetes mellitus undergoing hypoglycemic therapy may lead to hypoglycemia (such patients need dose adjustment).

Drug Interactions

Pentoxifylline is able to enhance the action of antihypertensive agents and anticoagulants.

In patients with diabetes mellitus, who are on insulin or taking antidiabetic drugs, Pentoxifylline can intensify the hypoglycemic effect of antidiabetic drugs, up to the occurrence of hypoglycemic reactions.

Reviews

We picked up some reviews of people who used the drug Pentoxifylline:

Victoria. The doctor prescribed Trental, but the pharmacy was advised to take cheaper Pentoxifylline as a complete analog. Side effects appeared after 2 days of taking the drug - nausea, heartburn and stomach pain. The pressure began to swim. There was a tachycardia. In the end, we "canceled" it and switched to a more expensive one, which is better tolerated, though not again trent ..
Rinat. I picked it up with my back. Osteochondrosis. The doctor prescribed Trental 400. On the advice of a pharmacy I bought Pentoxifylline. The drug is thermonuclear. The pain in the back disappeared after a couple of days, but side effects, in the form of headaches and stomach problems, caught in full, I had to lower the dose.
Oleg. All my friends drink this medicine. And the doctors prescribed them, and they recommended each other. And some people drink it, despite a lot of side effects. I think this is nonsense and we must urgently go to the doctor. Since persistent headaches are not a toy and this problem needs to be addressed. Perhaps pentoxifylline just does not suit them and that's all. Hence we must look for an analog.

Analogues

Analogues of the drug for the scope and indications are:

Dibazol;
Trental;
Vazonite;
Magnesium sulfate;
Polfilin retard;
A solution of Pentoxifylline;
Pentohexal;
Radomine;
Agapurin;
Flexitale;
Latren.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Keep Pentoxifylline recommended in a dry, dark place, while avoiding contact with children. According to the instructions for use, the prepared solution must be used immediately.