Valsakor tablets from high blood pressure

Valcator refers to the group of antihypertensive drugs that affect the receptors of angiotensin.

In its composition there is an active substance - valsartan. It is this that has the main treatment effect. The effect of the drug is to normalize blood pressure and reduce the overall peripheral resistance of blood vessels.

On this page you will find all information about the Valsakor: full instructions for use on this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Valsakor. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Angiotensin II receptor antagonist.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Valsakor cost? The average price in pharmacies is at the level of260 rubles.

Form of issue and composition

Produced in the form of round biconvex tablets with a dividing risk on one side. The main active ingredient of Valsacor is valsartan, the color of the film membrane and the size of the tablet distinguish its content in one piece, which can be:

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In brown-yellow - 40 mg, 160 mg or 320 mg;
In light pink - 80 mg.

Excipients: microcrystalline cellulose, silicon dioxide, colloid anhydrous, lactose monohydrate, povidone, magnesium stearate, croscarmellose sodium.

The Valsakor shell consists of:

Hypromellose;
Iron dyes - red oxide, yellow oxide (E172);
Titanium dioxide (E171);
Macrogol 4000.

In the pharmacy network comes in blisters for 7, 10, 14 tablets.

Pharmacological effect

The use of Valsacor allows to reduce peripheral resistance of blood vessels, normalize cardiac output and systolic pressure, improve the condition of patients with heart failure by reducing edema, dyspnea, respiratory noise. Valsakor does not affect the heart rate.

Valsakor H and Valsakor 160, in addition to valsartan, in their composition have hydrochlorothiazide, which has pronounced hypotensive properties. This substance increases the excretion of water, chlorine, potassium and sodium from the body. Valsartan and hydrochlorothiazide supplement each other's properties, and their interaction reduces the likelihood of side effects from taking Valsakor H and Valsacor 160.

In 14 days after the beginning of treatment with the drug, a significant antihypertensive effect is noted, which is also confirmed by reviews of Valsacore. The maximum result is observed on the 4-5 week of taking the drug. The effect of Valsakor persists throughout the day after taking one dose. Both valsartan and hydrochlorothiazide undergo rapid absorption in the digestive tract. About 40-70 percent of hydrochlorothiazide binds to plasma albumins, and valsartan is 98 percent. The active component of Valsacor is excreted mostly through feces and less in the urine.

Indications for use

What helps? Valsakor is prescribed for the following conditions and diseases:

Arterial hypertension.
Chronic heart failure in patients not taking ACE inhibitors.
Reduction of cardiovascular mortality in stable individuals who developed left ventricular dysfunction / failure as a result of myocardial infarction.

Contraindications

According to the instructions, the drug Valsakor is contraindicated for the treatment of patients with such conditions:

Anuria;
Persons who underwent renal transplantation;
The patient's age is 18 years;
Lactose insufficiency;
Stenosis of the renal artery;
Severe water-electrolyte balance disturbances, for example, with a strong fluid loss;
Individual intolerance of the constituent components of the drug;
Severe violations of the liver and kidneys;
The period of pregnancy and breastfeeding;

C special care is given to patients with vasculitis and systemic lupus erythematosus, stenosis of the aorta and mitral valve, as well as to persons with hypertrophic cardiomyopathy, accompanied by obstruction of large blood vessels.

Application in pregnancy and lactation

Valsartan is not used in therapy for pregnant women. If a woman does not plan a pregnancy, she must use reliable contraceptives, if pregnancy is planned, the drug is canceled.

Breastfeeding should be discontinued before the beginning of valsartan therapy, after consultation with the attending physician.

Instructions for use

The instructions for use indicate that the dose of Valsartan is selected individually, depending on the tolerability and degree of hypotensive effect.

Arterial hypertension:

Usually, a dose of 80 mg / day of valsartan is started (daily intake is taken at a time or divided into 2 divided doses). After 4 weeks after the start of therapy (the time to reach the maximum hypotensive effect), the dose is adjusted.
The maximum recommended dose of valsartan for treatment of arterial hypertension is 160 mg once every 24 hours or 80 mg once every 12 hours.
If, when taking valsartan at a dose of 160 mg / day, the necessary antihypertensive effect does not pass to therapy with Valsacor H or Valsacor HD. The dose of valsartan and hydrochlorothiazide when taken with preparations of Valsacor H and Valsacor HD is determined individually.
Patients with impaired liver function (without bile stasis) and kidney function (with a creatinine clearance of more than 30ml / min) do not need dose adjustment.

Increased survival of patients with acute myocardial infarction:

In patients with stable hemodynamics treatment should be started within 12 hours after the development of myocardial infarction. After the appointment of an initial dose of 20 mg 2 times / day, the dose of the drug Valsacor should be increased by titration up to 40 mg, 80 mg 2 times / day for several weeks to reach the target dose of 160 mg 2 times / day. The maximum daily dose is 320 mg 2 times / day.
As a rule, taking into account the tolerability of therapy, it is recommended to increase the dose to 80 mg 2 times / day by the end of the second week of treatment and to the maximum target dose of 160 mg 2 times / day - by the end of the third month of therapy. In the case of symptomatic arterial hypotension or renal dysfunction, it is advisable to consider the question of dose reduction.
The drug Valsacor can be used in patients after myocardial infarction against the background of therapy with other drugs, including thrombolytics, acetylsalicylic acid as antiplatelet agent, beta-blockers, inhibitors of HMG-CoA reductase (statins) and diuretics. It is not recommended to use Valsacor at the same time as ACE inhibitors.

Heart failure:

Usually, a dose of 80 mg / day is started (the dose is divided into 2 divided doses). Gradually, taking into account the tolerability of valsartan, the dose is increased to 160 mg once every 12 hours.
The maximum permissible daily dose of valsartan is 320 mg.
With concomitant diuretic therapy, the maximum permissible daily dose of valsartan is 160 mg.

The maximum permissible daily dose of valsartan is 320 mg.

Side effects

The use of Valsacor can cause the following side effects on the part of various systems of vital activity of the body:

Musculoskeletal system: myalgia, back pain, arthralgia;
Digestive system: abdominal pain, diarrhea, nausea;
urinary system: impaired renal function;
Reproductive system: decreased libido;
Central and peripheral nervous systems: headache, vertigo, dizziness, fainting, insomnia;
Respiratory system: pharyngitis, sinusitis, cough, rhinitis, infections of the upper respiratory tract;
The cardiovascular system: severe arterial hypotension, heart failure;
Allergy: rash on the skin, angioedema, hypersensitivity reactions (vasculitis, serum sickness), itchy skin;
Laboratory indicators: a decrease in the level of hematocrit and hemoglobin, hyperkalemia, neutropenia, hypercreatininemia, increased activity of hepatic enzymes, thrombocytopenia, hyperbilirubinemia;
Other side effects: increased fatigue, general weakness, asthenia, swelling.

Overdose

There were no cases of drug overdose in medicine, however, when the tablets were used spontaneously and there was a significant excess of the recommended daily dose in patients may dramatically decrease blood pressure, confusion, collapse, in rare cases, shock and coma.

When the first symptoms of drug overdose appear, the patient is given to take enterosorbents. If necessary, wash the stomach and perform symptomatic treatment. To correct a greatly reduced blood pressure, the patient is intravenously injected with a solution of sodium chloride isotonic.

special instructions

In patients with impaired renal and hepatic function, dose changes are not required.
It is possible to use Valsacor at the same time as other drugs prescribed after the transfer myocardial infarction: acetylsalicylic acid, thrombolytics, statins and beta-blockers.
When an arterial hypotension occurs with clinical manifestations of the patient should be placed on the back. If necessary, intravenously injected 0.9% solution of sodium chloride. Admission Valsakora can continue only after the stabilization of blood pressure.
In patients with severe deficiency in the body of sodium and / or reduced volume of circulating blood (for example, because of reception of large doses of diuretics) sometimes at the beginning of treatment there can be expressed arterial hypotension. Before the beginning of therapy it is recommended to restore the content of electrolytes and fluid in the body, in particular, reducing the dose of diuretics.
Patients with unilateral or bilateral stenosis of the renal arteries need to constantly monitor the content of urea nitrogen and creatinine in the serum.
Due to the lack of sufficient data on the use of Valsacor in severe renal failure (clearance creatinine <10 ml per minute or 0.167 ml per second), the drug should be used with caution.
In patients with obstructive diseases of the bile ducts, a decrease in the clearance of Valsacor is observed, and therefore the drug should be administered with caution.
The use of Valsacor in patients with heart failure is usually accompanied by a decrease in blood pressure, However, in compliance with recommendations for the selection of doses of arterial hypotension is rarely the reason for the abolition of therapy. Treatment of patients with heart failure should be started cautiously. In some patients, renal angiotensin-aldosterone system can be altered due to renal function. In severe heart failure, progressive azotemia and / or oliguria can develop up to acute renal failure and / or death (rarely). In patients with heart failure, it is necessary to constantly monitor the kidney function with simultaneous application of the combination 3 classes of drugs - beta-adrenoblockers, ACE inhibitors and angiotensin II AT1 receptor antagonists.

During therapy, patients are advised to use caution when driving vehicles and other mechanisms that require them to pay special attention.

Drug Interactions

With simultaneous use with indomethacin, a decrease in the antihypertensive effect of Valsakor is possible.
At simultaneous application with lithium carbonate the case of development of lithium intoxication is described.
With the simultaneous use of potassium-sparing diuretics, heparin, biologically active additives or substitutes for salt containing potassium, the development of hyperkalemia is possible.
With the simultaneous use of diuretics in high doses, it is possible to develop arterial hypotension.
With thiazide diuretics, medicines such as ethanol (alcohol), barbiturates and opioid analgesics, can potentiate the risk of developing orthostatic hypotension.

Reviews

We picked up some of the people's feedback on the drug Valsakor:

Olga. The drug I take 2 weeks. Pressure jumps ceased, above 160/100 does not rise (during the period of excitement), the last 2 months was almost always 210/120. A dose of 80 ml. I still do not see any side effects.
Tatyana. I got out all the pobochki, unbearable headaches, pharyngitis, cough, but the worst thing is that the amount of urine released decreased. The pressure of jumping became even more often.10 days a half-sleepless state with nausea and headaches, and now the 3rd day the body can not get better. Pressure in general became uncontrollable, so be careful with this drug.
Galina. Hello. I was prescribed this medication to lower the pressure of the most minimal dose of 80 mg. I take it for the night, in the morning the pressure drops very much and it is necessary to drink coffee to raise it a little, because it feels weak and dizzy, only after dinner the pressure is slightly leveled, all day I feel "not at ease", by the evening the organism comes more or less back to normal. Tried 2 days to divide the pill into 2 parts and drink respectively 40 mg at night and in the morning. This option seems to be better. I have been taking valsacor for 9 days. Decreases the pressure very well. Now the question is: to change the valsakor to the previous enap or to drink until 2 weeks, because the instructions say that accumulation only comes in 2 weeks. Reduces the pressure very much.