Milgamma nyxes: instructions for use

Milgamma is a combined drug containing vitamins of group B, analgesic, neuroprotective and metabolic action.

It is used for the treatment of diseases of the motor apparatus due to analgesic and anti-inflammatory properties, as well as the ability to stimulate the regeneration of tissues.

In addition, their pharmacological "summary" includes such an important quality as neurotrophy, i.e. participation in the processes occurring in the nervous system, including the metabolism of neurotransmitters and the transmission of nervous impulses.

Clinical and pharmacological group

Complex of B vitamins.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Milgamma cost? The average price in pharmacies is at the level of300 rubles.

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Form of issue and composition

• in one ampoule contains: active ingredients: thiamine hydrochloride 100 mg, pyridoxine hydrochloride 100 mg, cyanocobalamin 1 mg.
• auxiliary substances: lidocaine hydrochloride, benzyl alcohol, sodium polyphosphate, potassium hexacyanoferrate, sodium hydroxide, water for injection.

Pharmacological effect

Milgamma is a complex preparation based on B vitamins. Neurotropic B vitamins have a beneficial effect on inflammatory and degenerative diseases of the nerves and motor apparatus. Promotes increased blood flow and improves the functioning of the nervous system.

1. Vitamin B1 in the form of thiamine diphosphate and thiamine triphosphate plays a key role in the metabolism of carbohydrates, being a coenzyme of pyruvate decarboxylase, 2-oxoglutarate dehydrogenase and transketolase. In the pentose phosphate cycle, thiamin diphosphate is involved in the transfer of aldehyde groups.
2. Vitamin B6 in its phosphorylated form (pyridoxal-5-phosphate) is a coenzyme of numerous enzymes, taking part primarily in the metabolism of amino acids, as well as carbohydrates and fats.
3. Vitamin B12 is essential for cellular metabolism, hematopoiesis and the functioning of the nervous system. It stimulates nucleic acid metabolism through the activation of folic acid. In large doses, cyanocobalamin has analgesic, anti-inflammatory and microcirculatory effects.

The substance Lidocaine, which is a part of Milgramam, also has an anesthetic effect.

Indications for use

Milgamma is recommended as a pathogenetic and symptomatic agent in the complex therapy of diseases and syndromes of the nervous system of various genesis:

1. Neuralgia;
2. Neuritis;
3. Neuropathy;
4. Plexopathy;
5. Retrobulbaric neuritis;
6. Paresis of the facial nerve;
7. Polyneuropathy (diabetic, alcoholic);
8. Ganglionitis (including herpes zoster);
9. Nocturnal muscle cramps, especially in older age groups (for solution);
10. Neurological manifestations of osteochondrosis of the spine: radiculopathy, lumboishialgia, muscular-tonic syndromes (for solution).

Contraindications

The drug has contraindications:

1. Children and adolescents under 16 years.
2. Supersensitivity to Group B vitamins.
3. Violation of conduction processes of the heart muscle.
4. Heart failure.

Hypersensitivity to lidocaine or other amide local anesthetics, history of epileptiform seizures with lidocaine, severe bradycardia, severe arterial hypotension, cardiogenic shock, severe forms of chronic heart failure (grade II-III), sinus syndrome node, Wolff-Parkinson-White syndrome, Adams-Stokes syndrome, II and III degree blockade (AV), hypovolemia, severe liver / kidney dysfunction, porphyria, myasthenia gravis.

Use in pregnancy and lactation

During pregnancy and lactation, daily intake of vitamin B1 in a dose, mg per day, vitamin B6 mg per day is recommended. The intake of these doses can be recommended only if these vitamins are deficient. Safety of higher doses has not been investigated.

Vitamins B1 and B6 penetrate into breast milk.

High doses of vitamin B12 can inhibit lactation.

The decision to use these medicines during pregnancy and lactation should be taken after a careful weighing of the risk / benefit ratio.

Dosage and route of administration

The instructions for use indicate that the drug Milgamma is injected deep in / m. Weekly monitoring of therapy by the doctor is recommended.

• In cases of severe pain syndrome, to quickly achieve a high level of the drug in the blood, it is advisable to start treatment with an intravenous drug in a dose of 2 ml daily for 5-10 days. In the future, after the abatement of the pain syndrome and with mild forms of the disease, either the therapy with a medicinal form for oral administration (for example, Milgamma compositum) or for rarer injections (2-3 times a week for 2-3 weeks) with the possible continuation of therapy with the oral dosage form (for example, Milgamma compositum).

The transition to therapy with a dosage form for oral administration (for example, Milgamma compositum) is recommended in the shortest possible time.

Side effects

Allergic reactions are possible: rarely - shortness of breath, urticaria, skin rash, Quincke's edema, anaphylactic shock.

In addition, injections of Milgamma can cause side effects:

1. Cardiovascular system: very rarely - tachycardia; in some cases - arrhythmia, bradycardia;
2. Nervous system: in some cases - confusion, dizziness;
3. Digestive system: in some cases - vomiting;
4. Musculoskeletal system: in some cases - convulsions;
5. Dermatological reactions: very rarely - itching, increased sweating, acne;
6. Local and systemic reactions: in some cases, irritation at the injection site; overdose or rapid administration - an increase in the manifestation of systemic reactions.

Against the background of the treatment of Milgamma Dragee, it is possible to develop unwanted reactions:

• Cardiovascular system: in some cases - tachycardia;
• Other: in some cases - increased sweating, acne.

Overdose

More often when an overdose develops systemic side effects (arrhythmia, sweating, etc.). Treatment of overdose is aimed at carrying out symptomatic measures, it is necessary to cancel the drug.

special instructions

In case of accidental IV, the patient should be under the supervision of a doctor or be hospitalized depending on the severity of the symptoms.

Information about caution regarding the use of the drug by drivers of vehicles and persons working with potentially dangerous mechanisms is not available.

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

1. Copper accelerates the destruction of thiamine.
2. Thiamine loses its effectiveness with increasing pH (more than 3).
3. Thiamin is completely destroyed in solutions containing sulfites. And as a consequence, thiamine decay products inactivate the actions of other vitamins.
4. Thiamin is incompatible with oxidizing and reducing compounds, incl. iodides, carbonates, acetates, tannic acid, iron ammonium citrate, phenobarbital, riboflavin, benzylpenicillin, dextrose, disulfites.
5. When parenteral application of lidocaine in the case of additional use of norepinephrine and epinephrine may increase the side effect on the heart. Interactions with sulfonamides are also observed.
6. Therapeutic doses of pyridoxine weaken the effect of levodopa (the antiparkinsonian action of levodopa is reduced) with simultaneous admission. There is also interaction with cycloserine, penicillamine, isoniazid.
7. Cyanocobalamin is incompatible with salts of heavy metals. Riboflavin also has a destructive effect, especially when exposed to light; nicotinamide accelerates photolysis, while antioxidants have an inhibitory effect.

Reviews

We picked up some feedback from people who used Milgamma:

1. Sergei. The wife from the youth suffers pains in a back, result of employment of judo. After the birth of the first child it became quite unbearable, almost climbing the wall from pain. Has passed or has taken place inspection, has made MRT a lumbar department of a backbone. The diagnosis is protrusion of the discs and pinching of the sciatic nerve. The attending physician prescribed intramuscular injections with Milgamma. It was a rescue! After the course of injections, my wife almost forgot about the pain in her back. Now, with rare attacks, he definitely uses Milgamma. The second pregnancy and childbirth passed perfectly, without complications. The only downside: injections are very painful.
2. Paul. After the trauma I need regular support of the body with vitamins of group B. Previously, chop them separately, walked like a sieve))) Finally there was a modern drug Milgamma compositum in tablets, which includes everything you need, very convenient.
3. Arseny. The composition of the drug - a complex of vitamins B, which have a positive effect in diseases associated with neurological disorders. As a medical worker, I want to say that the medicine acts on the general restorative body, significantly reduces pain syndromes. My relatives use injections with radiculitis, dorsal neuralgia. Sam tried the drug when I developed neuralgia of the trigeminal nerve.
4. Stephanie. I was prescribed 10 injections, and I only pierced 5. I was terribly surrounded, the whole body, faces, neck, hands. Just awful!!! Soon the New Year, and I even show shame. I work as a teacher, I'm so ashamed. I should have had side effects before

Analogues

Structural analogs for the active substance:

• Binavit;
• Vitagamma;
• Kombilipen;
• Complymgam;
• Trigamma.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Milgamma in ampoules is stored at a temperature below 15 degrees (the refrigerator door). It is important to protect the drug from direct sunlight. Shelf life 2 years.

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