What helps Lidaz: instructions for use

Lidase - an enzyme agent isolated from the testes of cattle with proteolytic activity, rendering kelloidolytic action, which increases the permeability of capillaries, resorbing scar tissue.

The active substance - hyaluronidase, is engaged in the cleavage of hyaluronic acid, reduces its viscosity, facilitating movement. Maximally reduces puffiness, makes the scars softer and more flat, reduces contractures and protects from their appearance.

The drug is prescribed in cases of formation of post-burn or postoperative scars, hematomas, contractures joints, corneal scars and retinopathy, as well as tuberculosis, myocardial infarction, hydrocephalus.

Clinical and pharmacological group

Medicinal preparation of keloidolytic action. Degrades the tissue of the scars and increases the permeability of the capillaries.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Lydas cost? The average price in pharmacies is at the level of240 rubles.

Form of issue and composition

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The medicament in question is made using testes of cattle (large). This drug is based on the enzyme hyaluronidase, as well as additional substances.

Currently, this product is available in several forms:

powder intended for external use;
solution "Lidase", or rather lyophilizate for its preparation; it can be used for both injection and local application;
lyophilisate, intended for solution preparation (for local and external use).

One can not but say that some doctors prescribe to their patients and candles with Lidazy. However, it should be borne in mind that such suppositories are not commercially available. They can be ordered at the pharmacy on a special medical prescription.

Pharmacological effect

The basis of this medication is the enzyme hyaluronidase, which is isolated from the testes of cattle.

Due to this enzyme, the use of Lydase causes the cleavage of hyaluronic acid (which is a cementing component of the connective tissue), reduces its viscosity, increases tissue and vascular permeability, softens the scars and reduces swelling.

The drug reduces and prevents contractures.

Indications for use

What helps? Indications for the use of the drug "Lidase" are:

hydrocephalus;
tuberculosis;
inflammatory processes localized in the bronchi and lungs;
myocardial infarction;
complex treatment of arachnoiditis and rhinitis caused by allergy;
if a late form of neurosyphilis pathology is diagnosed;
scars caused by burns, injuries or surgical intervention;
low mobility of joints;
contracture of joints and Dupuytren;
pathology associated with deformation of lumbar discs;
chronic form of tenosynovitis;
scleroderma (including systemic, localized, focal);
lesions of peripheral nerves and their plexuses that have arisen as a result of trauma.

Contraindications

Do not use the drug:

Infectious-inflammatory diseases in acute phase;
Fresh vitreous hemorrhage;
Concomitant use of estrogens;
Recent hemorrhages;
Hypersensitivity.

Additional contraindications for inhalation:

Malignant neoplasms;
Hemoptysis, pulmonary hemorrhage;
Tuberculosis of the lungs with severe respiratory failure;
Acute intercurrent diseases.

With caution appoint Lydas during pregnancy, as well as during breastfeeding (lactation).

Dosage and route of administration

The instructions for use indicate: Lidazoy injections are prescribed in the treatment of cicatricial lesions:

Subcutaneously - by the introduction of scar-altered tissue;
Intramuscularly - by introducing into the area that borders on the site of the lesion.

As a rule, injections of Lydase are prescribed in a dosage of 1 ml daily or every other day. Course treatment includes 10 to 20 injections.

Also, injections of Lydase (subcutaneously) are prescribed in the treatment of peripheral nerves and traumatic lesions of the nerve plexuses. The medication is introduced into the affected nerve region in an amount of 1 ml every other day. The course of treatment includes 12-15 injections, which, if necessary, can be repeated.

In ophthalmology, electrophoresis with Lydase is used, and administration of the drug is possible subconjunctival (0.3 ml) and parabulbar (0.5 ml each).

In the treatment of pulmonary tuberculosis, which is productive of inflammation, Lydas is usually prescribed as a part of complex therapy to increase the concentration of antibacterial drugs in the lesions. The medicine is prescribed:

In the form of injections - daily;
In the form of inhalations - daily, 5 ml once a day, a course of 20-25 inhalations.

External Lidazu used in the form of bandagesmoistened with a solution of the drug. Each 64 UE (1 vial) is dissolved in 10 ml of boiled water cooled to room temperature, or 0.9% sterile sodium chloride solution. The resulting solution is moistened with a bandage folded in 4 or 5 layers, and then applied to the affected area and covered with wax paper. To fix the application use a soft bandage. The duration of one procedure is 15-18 hours. The course of treatment is 15-60 days. With therapy for a long time every 2 weeks, you should take a break for 3-4 days. The application of Lydase can be alternated with the method of electrophoresis.

Side effects

As practice shows, Lidase medication is tolerated by patients quite well, even with high sensitivity and very complex forms of the disease.

In rare cases, the drug in question can cause an allergic reaction, which manifests itself in the form of skin lesions.

Overdose

Overdosing manifests as nausea, tachycardia, dizziness, vomiting, chills, lowering of arterial pressure, erythematous rashes, local edema, urticaria.

Treatment of an overdose consists of taking antihistamines, glucocorticosteroids and epinephrine.

special instructions

Before starting treatment, a test with intradermal administration of 20 μl of hyaluronidase is recommended.

Solution for injection is prepared using 0.9% solution of sodium chloride or 0.5% solution of procaine, for electrophoresis - distilled water, for inhalations - 0.9% solution of sodium chloride.

The drug should not be administered through a catheter through which previously injected solutions, which include cations.

Do not inject into the tumor and the area of infectious inflammation.

Drug Interactions

This drug enhances the effect of anesthetics (local) and is often used to improve absorption of drugs.

Lidase should be very carefully prescribed for use simultaneously with other medicines, because there is a large the probability of an increase in absorption that can not be predicted, and possibly a strengthening of systemic action.

Reviews

We picked up some reviews of people taking Lidase:

Victoria. With great confidence I treat this drug. After the operation of appendicitis, a colloid blue-burgundy rump protruding above the skin was formed. After 3 courses of injections of lidase and aloe, which alternated with electrophoresis for a year, the scar turned white, became soft and almost invisible. Lidase also helped me to resorb the scar, formed after a purulent left-sided otitis. Of course, you need to be patient, because there are no significant visual improvements of the scar condition, however, with the repetition of the course of treatment, eventually the desired effect can be achieved.
Lyudmila. The fact that lidase is mainly used in injections, I knew, and that there are candles of Longidaz. For the treatment of hematomas with a bruise of my mother, the doctor recommended making compresses based on lidase and dimexide. Since there was no open wound, 50% dimexide solution was used, and one ampoule of lidase was taken for 30 ml of the solution. Put a compress on the problem area and bandaged with a bandage. Such a compress quickly took off the puffiness, and the bruise quickly left.
Maria. I had a scar on my left leg from a burn, a scar is old - from childhood. Have appointed or nominated an electrophoresis with a lidase. I underwent two courses for 15 procedures, the scar, of course, did not completely disappear, but it became much smaller, the skin in place of the scar became softer, the scars flattened. And in the summer the burn was even sunburned, although before that the scar was always white. Lidase really helps with scars and scars, probably, fresh scars can be removed completely.