Hirabesol

Hirabezol is a product based on rabeprazole from HighGlans Laboratories (India). The drug is included in the therapy of patients with ulcerative formations in the digestive organs.

Is a representative of proton pump inhibitors. It blocks the secretion of hydrochloric acid (the final stage), reducing the stimulated and basal secretion. It penetrates well into the cells of the stomach, providing a cytoprotective effect.

Antisecretory action occurs within an hour, and the total time of action is 48 hours. Restoration of secretory activity is noted 3 days after the end of treatment. The drug has no effect on the cardiovascular system and the central nervous system.

Clinical and pharmacological group

H + -K + -ATPase inhibitor. Antiulcer drug.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does hirabesol cost in pharmacies? The average price is at the level of900 rubles.

Composition and form of release

Hairabezol - round tablets, convex on both sides, covered with a film membrane, due to which the active substance enters the intestine, where it is absorbed by the body.

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The active substance of the drug is rabeprazole sodium. The manufacturer offers the drug in two dosages differing in the color of the shell:

10 mg - from light pink to reddish-pink;
20 mg - from light yellow to yellow.

In addition, the preparation contains magnesium oxide, corn starch, sodium stearyl fumarate, low-substituted giprolase, mannitol, povidone K30. The shell is made of cellophate, titanium dioxide, iron oxide dye yellow or red.

Tablets are packed in strips or blisters, 10, 14, 15 pieces each. In a cardboard bundle - 1, 2, 10 strip or blister.

Pharmacological effect

Khayrabezol - a drug that has antiulcer effect. The active agent in the composition Hayrabezola - rabeprazole, refers to the group of proton pump inhibitors [Hydrogen potassium ATPase (H + / K + -ATPase)]. It is metabolized in the parietal cells of the stomach, rabeprazole cleaved to active derivatives of sulfanilamide, inactivating sulfhydryl groups of H + / K + -ATPase. The blocking of the final stage of hydrochloric acid secretion occurs due to a decrease in the basal and stimulated secretion, regardless of the etiology of the stimulus.

Possessing high lipophilicity, rabeprazole easily penetrates into the cells of the stomach, secreting hydrochloric acid and the internal factor of Castle, and, concentrating in them, has a cytoprotective effect. After oral administration at a dose of 20 mg, the antisecretory effect occurs within 1 hour, the maximum value reaches 2-4 hours. Inhibition of acid secretion through 23 hours after the first intake is: basal - 62%, stimulated by food - 82%. The duration of the drug is 48 h. The secretory activity is normalized after the end of the reception for 2-3 days.

At the beginning of treatment, for 2 to 8 weeks, the serum concentration of gastrin increases, and its return to baseline levels occurs 1-2 weeks after the discontinuation of the administration of hirabesol. The drug has no effect on the cardiovascular, central nervous and respiratory systems.

Indications for use

Hyrabezole is prescribed for the purpose of treatment and maintenance therapy for such diseases:

an anastomosis ulcer;
ulcers of the stomach and duodenum in the stage of exacerbation;
GERD (gastroesophageal reflux disease) with the formation of ulcers and erosions, reflux esophagitis;
non-erosive GERD;
Zollinger-Alison syndrome;
Other conditions for which pathological hypersecretion is characteristic.

The drug is administered alone or in combination with antibacterial agents for ulcer disease, the causative agent of which is Helicobacter pylori.

Contraindications

Before you start taking pills, the patient should consult a doctor and read in detail the attached annotation to the drug. Hirabezol is not prescribed for oral administration if the patient has one or more conditions:

severe hepatic impairment;
hypersensitivity to the drug or an individual intolerance to rabeprazole;
age to 18 years;
pregnancy and the period of breastfeeding;
severe kidney disease, accompanied by a violation of the function of the body.

Intended use for pregnancy and lactation

Investigations on the safety of the preparation Khairabezol for intrauterine development of the fetus and the course of pregnancy in general, not conducted, so the drug is not recommended during pregnancy.

It is unknown whether the drug is excreted in breast milk and how it can affect the baby. If it is necessary to treat the preparation with a lactating mother, you should think about the completion of lactation and the transfer of the baby to food with an adapted milk formula.

Dosage and route of administration

As indicated in the instructions for use, Khayrabezol is prescribed 20 mg 1 time / day. Tablets should be taken orally, in the morning before meals, swallowing whole, without chewing or grinding.

With peptic ulcer of duodenum and peptic ulcer of stomach at the stage of exacerbation appoint 20 mg (1 tab.) 1 time / day in the morning for 4-6 weeks.
In gastroesophageal reflux disease (GERD), 20 mg (1 tab.) Are prescribed 1 time / day for 4-8 weeks.
For maintenance therapy with GERD - in a dose of 10 or 20 mg 1 time / day, depending on the patient's response.
For symptomatic treatment of GERD in patients without esophagitis - in a dose of 10 mg 1 time / day for 4 weeks.
For the treatment of Zollinger-Ellison syndrome and other conditions characterized by pathological hypersecretion, the dose is selected individually.

For the treatment of duodenal ulcer or chronic gastritis associated with infection with Helicobacter pylori, a course of treatment of 7 days with one of the following combinations of drugs is recommended:

Khayrabezol 20 mg 2 times / day + clarithromycin 500 mg 2 times / day and amoxicillin 1 g 2 times / day.
Hirabezol 20 mg 2 times / day + clarithromycin 500 mg 2 times / day and metronidazole 400 mg 2 times / day.

Adverse Reactions

More common side reactions:

diarrhea, nausea;
headache.

Less common side reactions:

vomiting, flatulence;
abdominal pain and constipation;
dizziness;
insomnia;
nervousness;
depression;
myalgia, convulsions;
arthralgia;
cough, sinusitis;
sweating, weight gain;
rash, itching;
thrombocytopenia, leukopenia, leukocytosis.

Overdose

To date, cases of drug overdose are minimal, their symptoms are poorly described. Patients notice severe pain in the abdomen, vomiting, diarrhea. There is no specific antidote for removing rabeprazole from the body, the dialysis procedure is not effective. If you suspect a drug overdose, symptomatic therapy is performed.

special instructions

Before you start using the drug, read the special instructions:

Patients with impaired renal or hepatic function do not need a dose adjustment.
It is advisable to use caution in the first appointment of rabeprazole to patients with severe impairment of liver function.
Before and after treatment with rabeprazole, endoscopic control is necessary to exclude malignant neoplasm. treatment can mask symptoms and delay correct diagnosis.
The withdrawal of the drug is not accompanied by a rebound phenomenon, the recovery of secretory activity occurs within 2-3 days as the synthesis of new enzyme molecules.
The drug does not affect the function of the thyroid gland, the metabolism of carbohydrates, the concentration in the blood of parathyroid hormone, cortisol, estrogen, testosterone, prolactin, cholecystokinin, secretin, glucagon, follicle-stimulating hormone, luteinizing hormone, renin, aldosterone and somatotropic hormone.

Compatibility with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

Does not interact with liquid antacids.
Reduces the concentration of ketoconazole by 33%, digoxin by 22%.
Compatible with drugs metabolized by the CYP 450 system (warfarin, phenytoin, theophylline, diazepam).
Rabeprazole slows the excretion of certain drugs metabolized in the liver by microsomal oxidation (diazepam, phenytoin, indirect anticoagulants).

Reviews

We offer you to get acquainted with the opinions of people who used Hyrabesol:

Igor. I had an increased production of gastric juice and a condition close to gastritis. It was accompanied by pains in the abdomen, heartburn, nausea. The doctor prescribed me a drug Hirabezol to eliminate unpleasant symptoms, but he was ineffective. I underwent a one-month course, but did not notice any changes in the condition.
Rita. Hairabezol was prescribed to me by a gastroenterologist. Before that, I suffered from terrible pains in my stomach. Nothing helped or helped for a short time. Take very comfortable, small tablets, once a day in the morning. I immediately felt better on the first day of admission. Worth not so expensive. Thanks a lot to the doctor for the treatment.
Anna. Her husband has gastroesophageal disease, so he has to take medications constantly. Now the husband drinks Herabezol tablets, which the doctor prescribed to him. The husband notes that the drug is effective, fast and reliable, does not cause side effects. The spouse undergoes maintenance therapy, it will last another month.

Analogues

Structural analogs for the active substance:

Beret;
Zolispan;
Zulbeks;
Нофлюкс;
Ontime;
Parries;
Rabelock;
Rabeprazole;
Rabeprazole sodium;
Reason.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Keep the tablets in a cool place, away from children, avoiding direct sunlight on the packaging. The shelf life of the tablets is indicated on the package, after its expiration, the drug should not be taken orally.