Ketotifen Tablets: instructions for use

Ketotifen is an anti-asthmatic and antiallergic drug, which is a stabilizer of the membranes of mast cells.

This agent by inhibiting the current of calcium ions, as well as reducing their number in mast cells, prevents the release of histamine and other mediators of inflammation and allergies.

On this page you will find all information about Ketotifen: the full instructions for use for this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Ketotifen. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Stabilizer of membranes of mast cells. Anti-allergic drug.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Ketotifen cost? The average price in pharmacies is at the level of40 rubles.

Form of issue and composition

The drug can be administered in four versions: tablets, drops, soft capsules or syrup.

Tablets produce a flat-cylindrical round form of white hue. They have a dividing risk, a facet and a faint odor. They produce tablets in blisters (contour packs) of 10 pieces, which are placed in a cardboard box. Ketotifen - instructions for use are contained in each box, where there can be from 1 to 5 blisters.

• The active substance is ketotifen in the form of ketotifen fumarate.

Ketotifen tablets contain 1 mg of active ingredient. Additional substances: lactose monohydrate, starch, magnesium stearate.

The syrup contains 1 mg / 5 ml of the active ingredient.

Pharmacological effect

Ketotifen has an anti-allergic effect on the body. The therapeutic effect of the drug is based on inhibition of the release of histamine from mast cells. When taking the tablets inside, the therapeutic effect develops within 15 minutes and lasts up to 12 hours.

The drug has some sedative effect on the central nervous system.

Indications for use

What helps? Ketotifen is intended for long-term treatment and prevention of exacerbation of the following diseases:

1. Allergic conjunctivitis;
2. Allergic rhinitis;
3. Allergic bronchitis;
4. Atopic bronchial asthma;
5. Allergic dermatitis;
6. Acute and chronic urticaria;
7. Hay fever (hay fever) and its asthmatic complications.

Contraindications

• The period of breastfeeding;
• Hypersensitivity to the components of the drug.

In addition, the contraindication to the use of tablets is:

• Pregnancy period;
• Age to 3 years.

Do not administer syrup to babies under 6 months of age.

With caution, it is recommended that:

• Tablets: with hepatic insufficiency and patients with epilepsy;
• Syrup: the period of pregnancy, especially in the first trimester.

Application in pregnancy and lactation

The use of Ketotifen during pregnancy is possible only in exceptional cases, when the therapeutic effect of the drug exceeds the estimated harm. The drug should be taken under the compulsory supervision of the attending physician

Proceeding from the fact that the drug easily penetrates into breast milk, the use of Ketotifen during breastfeeding is contraindicated and possible only in the event of complete refusal of breastfeeding.

Instructions for use

The instructions for use indicate that Ketotifen tablets are taken orally, in the morning and in the evening during meals.

• Recommended dosage for adults and children - 1 tablet 2 times a day, in severe cases, an increase in the dose for adults to 2 mg 2 times a day is allowed. The treatment period is 3 months or more.

The drug should be withdrawn gradually, within 2-4 weeks.

Ketotifen for children in the form of syrup

In this form, Ketotifen is assigned to activities. According to the instructions, it is possible to drink medicine for babies between the ages of 6 months to 3 years.

To the child the dosage is calculated by the formula: per 1 kg of body weight 0.25 mg of syrup. The drug should be taken to a small patient twice a day. After reaching the age of three, the ketotifen syrup can be drunk in a therapeutic dose at a therapeutic dose: 5 ml 2 times / day during meals.

Side effects

Side effects of Ketotifen include constipation, vomiting, impaired digestion, increased appetite, dryness mouth, slow reaction speed, fatigue, dizziness, drowsiness and nervousness.

The drug can cause the development of cystitis (inflammation of the bladder), a violation of urination, increase in body weight, development of thrombocytopenia (decrease in the number of platelets) and skin reactions.

Overdose

If the daily dose recommended in the instructions is exceeded, the symptoms of overdose develop rapidly in patients, which are manifested by the following clinical symptoms:

1. The inhibition of psychomotor reactions and the inhibition of certain reflexes;
2. Decrease in blood pressure;
3. Cyanosis of the skin;
4. Confusion of consciousness;
5. Bradycardia;
6. Convulsions;
7. In severe cases, the development of coma is possible.

When revealing the first signs of drug overdose, the patient should urgently cause vomiting, rinse the stomach and enter into the enterosorbents. These techniques are effective only if a little time has elapsed since the drug was administered.

special instructions

1. It is not intended for arresting an attack of bronchial asthma.
2. Persons sensitive to sedation, in the first 2 weeks, the drug is prescribed in small doses.
3. In patients who are simultaneously receiving oral hypoglycemic agents, the number of platelets in the peripheral blood should be monitored.
4. Undesirable abrupt reversal of the previous treatment with beta-adrenostimulants, glucocorticosteroids, adrenocorticotropic hormone (ACTH) in patients with bronchial asthma and bronchospastic syndrome after adherence to ketotifen therapy, cancellation is carried out for a minimum of 2 weeks, gradually reducing the dose. Treatment is stopped gradually, within 2-4 weeks (a relapse of asthmatic symptoms is possible).

During the treatment period it is necessary to refrain from driving motor vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Drug Interactions

Ketotifen can greatly enhance the effect on the human body of hypnotics, ethyl alcohol and antihistamines. If you combine this drug with hypoglycemic drugs, then the probability of developing a patient's thrombocytopenia is high. Such people should constantly monitor the number of platelets in the peripheral blood.

Patients with bronchospastic syndrome or bronchial asthma do not want a sharp withdrawal of adrenocorticotropic treatment hormone, glucocorticosteroids and beta-adrenostimulyatorami after the addition of Ketotifen. Abolition of these drugs should be carried out within 14 days, reducing the dose gradually, so that there is no recurrence of asthmatic syndrome.

Reviews

We picked up some feedback from people about the Ketotifen:

1. Liuba. In the first months of summer, when all normal people enjoy the first greenery and flowering, my illness makes life just unbearable. The thing is that I have bronchial asthma, and during this period it is exacerbated by allergic reactions to flowers, pollen and grass. From the nose it constantly flows, eyes itch, attacks of suffocation. During this period, "Ketotifen" always helps me. It removes allergic reactions, prevents asthma attacks, facilitates breathing. I have been saving Ketotifen for more than 10 years. I do not notice any side effects from using the drug, maybe I just got used to it. At a price tablets are quite affordable.
2. Alexey. In the middle of May he began sneezing continuously + a runny nose, came to the pharmacy to take "something from an allergy." The pharmacists offered a choice of several drugs, depending on the chance and price, took ketotifen. I have been drinking for a couple of weeks, almost do not notice the symptoms of my allergy. I do not feel any side effects.
3. Natalia. Ketotifen is an obsolete domestic drug. Adverse events do exceed the therapeutic effect. I like Kestin, but one tablet is not enough for a day. The best drug is Claritin!!! but it's too expensive!

Analogues

Structural analogs for the active substance:

• Zaditen;
• Zaditen SRO;
• Ketotifen Sopharma;
• Ketotifen Stade;
• Ketof;
• Positon;
• Stafen;
• Frenasma.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Store in dry (tablets), dark and inaccessible to children at a temperature of: tablets - up to 25 ºС, syrup - 5-15 ºС.

Shelf life - 3 years.

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