Amigrenin tablets: instructions for use

Amigrenin is an anti-migraine remedy, which, in the first hours, can alleviate pain and reduce concomitant symptoms.

Triptane preparations have been specifically developed to combat migraine headaches. The effect of the drug is based on the elimination of violations of the balance of serotonin in the body.

On this page you will find all information about Amygrenin: full instructions for use on this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Amigrenin tablets. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

The 5-HT1 receptor agonist. The drug with antimigraine activity.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Amigrenin cost? The average price in pharmacies is at the level of270 rubles.

Form of issue and composition

The medicine is produced in the form of coated tablets, each of which contains:

50 or 100 mg of sumatriptan (as sumatriptan succinate);

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Such auxiliary substances as lactose, sodium carboxymethyl starch, microcrystalline cellulose, magnesium stearate, potato starch.

The composition of the envelope includes: macrogol 4000, titanium dioxide, talc, povidone, hypromellose.

2 tablets are sold. in contour mesh containers, located in cardboard packs.

Pharmacological effect

Anti-migraine drug. A specific selective agonist of serotonin 5HT1B-1D receptors (5-hydroxytryptamine-1-like), located predominantly in the smooth muscle of the walls of the blood vessels of the brain.

Stimulation of 5HT1 receptors results in selective narrowing of the vessels in the carotid artery system and reduction processes of neurogenic inflammation, without significantly affecting cerebral blood flow. In addition, it has been experimentally established that sumatriptan inhibits the activity of the trigeminal nerve.

Indications for use

According to the instructions to Amigrenin, this drug is indicated for use in two cases:

With the purpose of arresting painful sensations in acute migraine attacks, as well as eliminating their symptoms (with migraine with aura and without);
For the purpose of relief of pain in Horton's syndrome (histamine cephalalgia).

Contraindications

According to the annotation to the drug, the use of Amigrenin is contraindicated in patients with:

Ischemic heart disease;
Expressed violations of liver function;
Hemiplegic, ophthalmoplegic and basilar form of migraine;
Uncontrolled hypertension;
Occlusion diseases of peripheral arteries;
Stroke or transient impairment of cerebral circulation (in history including).

Also, it is forbidden to take Amigrenin:

To people of advanced age (over 65 years);
In the presence of hypersensitivity to sumatriptan or any auxiliary component of the drug;
Simultaneously with MAO inhibitors and within 14 days after their cancellation;
For prevention of migraine;
Pregnant women;
During lactation;
Children and teenagers under 18;
Simultaneously with medications, which include ergotamine or its derivatives.

Application in pregnancy and lactation

The drug is contraindicated for use in pregnancy and lactation (breastfeeding).

Instructions for use Amigrenin

In the instructions for use it is indicated that the standard dosage of Amigrenin is 50 mg. If the dosage is insufficient and, consequently, the effect is weak, the dosage is increased to 100 mg. The maximum dosage of sumatriptan daily is 300 mg.

If the effect is absent at all, then there is no point in taking the drug again. With the resumption of symptoms after a certain time, a repeated dose is recommended

Side effects

According to reviews Amigrenin can cause side effects:

Cardiovascular system: arterial hypotension, palpitation, tachycardia, an attack of angina, hyperemia of the mucous membranes and skin, transient ECG changes in ischemic type, transient increase in arterial pressure, bradycardia; manifestations of Raynaud's syndrome - in some cases;
Digestive system: abdominal discomfort, nausea, dysphagia, vomiting, increased activity of liver enzymes, ischemic colitis;
Central nervous system: drowsiness, dizziness, fatigue, weakness, visual impairment (decreased severity, scotoma, diplopia);
Allergic reactions: urticaria, erythema, pruritus, anaphylaxis.

Reviews to Amigrenin also note myalgia, sensations of heaviness, tingling, pressure, heat, compression in different parts of the body.

Overdose

Exceeding the dose of the drug above the level of the average therapeutic dosage, the symptoms of side effects develop. If they occur, stop taking the pills and seek medical help.

special instructions

Amigrenin should not be used for prophylactic purposes.

Before prescribing sumatriptan to patients with a newly diagnosed migraine or atypically occurring, other potentially neurological diseases should be excluded. It should be borne in mind that in patients suffering from migraine, there is a risk of developing a stroke or transient disorders of the cerebral circulation.
In patients with hypersensitivity to sulfonamides with the introduction of sumatriptan, there is an increased risk of allergic reactions (from skin manifestations to anaphylactic shock).
Do not prescribe to patients with suspected heart disease without a prior examination. The first 2-3 administration of the drug should be carried out under the supervision of a doctor (coronary artery spasm is possible).
If there is no effect on the administration of the first dose, the diagnosis should be clarified.

The experience with sumatriptan in patients older than 65 years is limited (there is no significant difference in pharmacokinetics compared with younger patients). Since the use of Amigrenin may cause drowsiness, care should be taken when driving a car and working with mechanisms

Drug Interactions

It is inadmissible to receive at the same time: funds containing ergot alkaloids; lithium preparations; inhibitors of reverse neuronal seizure of serotonin; inhibitors of MAO.

Reviews

According to reviews, Amigrenin is a highly effective drug. He begins to act very quickly and helps to get rid of the painful headache provoked by a migraine attack. In some patients, adverse reactions were observed, but very minor, so that patients continued to take the remedy to avoid relapse of seizures.

Analogues

Imigran, Sumitran, Antimigren, Sumamigren, in their essence, also contain sumatriptan. Another analogue, similar to this drug for the therapeutic effect, is the drug Zomig, the active substance of which is zolmitriptan.

Before using analogues, consult your doctor.