Fromiloid Uno

Fromomil and Fromiloid Uno are antibiotics of the macrolide class with the active substance clarithromycin.

It is available in the form of tablets with 250 mg of active ingredient, and Unil Formyl is a prolonged-release tablet with 500 mg clarithromycin, which release it gradually, during the passage of the tablet through the gastrointestinal tract.

Fromilide is active against intracellular bacteria (legionella, mycoplasmas), mycobacteria, except tuberculosis, gram-positive and gram-negative microorganisms and some anaerobic bacteria. The drug is prescribed for infectious and inflammatory diseases of the respiratory tract, skin and soft tissues, with chlamydia, in combination with other drugs for Helicobacter pylori infection.

Clinical and pharmacological group

Antibiotic group macrolides.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much is Fromilo Uno in pharmacies? The average price is at the level of290 rubles.

Composition and form of release

The preparation of Formyloid Uno is available in the form of tablets for oral administration. The tablets are yellow, oval, convex on both sides, covered with a protective film shell, long-lasting. The drug is packaged in blisters of 5 or 7 pieces (1-2) in a cardboard box with the attached annotation with a full description of the characteristics of the antibiotic.

1 tablet contains:

• active ingredient: clarithromycin - 500 mg (equivalent to the active substance content - 980-1020 μg / mg);
• auxiliary ingredients: sodium calcium alginate, sodium alginate, lactose monohydrate, polysorbate-80, povidone, silicon colloidal dioxide, magnesium stearate, talc;
• film shell: hypromellose, iron oxide yellow dye (E 172), titanium dioxide (E 171), propylene glycol, talc.

Pharmacological effect

Fromilide is a medicine, an antibacterial agent that belongs to a macrolide group. It has a bacteriostatic effect on various microorganisms by inhibiting protein production in microbial cells. Some agents have a bactericidal effect.

The drug is effective in fighting intracellular infectious agents, Gram-positive gambling negative microorganisms. It also acts on all mycobacteria (except for M. tuberculosis), on some anaerobic pathogens.

Indications for use

Frohilide Uno and Ofomilid is prescribed for the treatment of the following diseases:

• mycobacterial diseases;
• in the complex treatment of Helicobacter pylori infection;
• preventive measures against people with AIDS;
• infectious diseases of the respiratory tract (bronchitis, tonsillopharyngitis, acute sinusitis, otitis media);
  infectious diseases of the skin and soft tissues (erysipelas, infections with wounds, furuncle, carbuncle).

Contraindications

Before starting therapy, the patient must be sure to take blood tests and swabs from the throat and nose to differentiate the pathogen. Before taking the tablets, you should carefully read the product's annotation, since Formylid Uno has a number of contraindications:

• the period of breastfeeding;
• congenital lactose intolerance, lactase insufficiency;
• individual intolerance to the components of the drug;
• the patient's age is up to 12 years (this is due to the fact that the experience of using the drug in pediatric practice is absent, and the safety of the antibiotic is not established);
• pregnancy in 1 trimester;
• severe diseases of the kidneys and liver, accompanied by a violation of the function of the body;
• chronic renal failure.

Relative contraindications to the use of the drug are:

• pregnancy 2 and 3 trimesters;
• myasthenia gravis;
• diabetes;
• simultaneous therapy with drugs, the metabolism of which occurs in the liver.

Intended use for pregnancy and lactation

The use of the drug in the first trimester of pregnancy is contraindicated. Use of the drug, Formyloid uno in the II and III trimesters of pregnancy, is only possible if the intended benefit to the mother exceeds the potential risk to the fetus.

Clarithromycin excreted in breast milk, so if you need to use the drug during lactation, breastfeeding should be discontinued.

Dosage and route of administration

As indicated in the instructions for use of 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 Tablets should be swallowed whole, not breaking and not chewing.

• Adults prescribe in a dose of 500 mg (1 tab.) 1 time / day.
• In severe infections: 1000 mg (2 tab.) 1 time / day.
• The course of treatment is 5-14 days, with community-acquired pneumonia and sinusitis - 6-14 days.

In elderly patients, there is no need to change the dose of clarithromycin, except in cases of severe renal dysfunction.

It should not be used from the fatylate uno with KK <30 ml / min.

In patients with hepatic insufficiency, dose adjustment is not required.

Adverse Reactions

Classification of the World Health Organization (WHO) to determine the incidence of side effects: very often - not less than 0.1%; often from 0.01 to 0.1%; infrequently from 0.001 to 0.01%; rarely from 0.0001 to 0.001%; extremely rarely - less than 0.0001%, including individual cases; with an uncertain frequency - it is impossible to estimate the frequency based on the available data.

The frequency of side effects due to the administration of formyloid uno by systems and organs:

• sensory organs: often - dysgeusia (distortion / loss of taste sensations); infrequently - noise (ringing) in the ears, up to loss hearing (it is restored after the withdrawal of foromyloid uno), vertigo; extremely rare - cases of impaired smell;
• cardiovascular system: infrequently - ventricular tachycardia, including pirouette-type arrhythmia, flutter / fibrillation of the ventricles, prolongation of the QT interval on the ECG;
• hemopoietic system: rarely - thrombocytopenia (unusual hemorrhage, bleeding), leukopenia; with an uncertain frequency - agranulocytosis;
• musculoskeletal system: infrequently - arthralgia, myalgia; with an uncertain frequency - myopathy;
• digestive system: often - nausea, dyspepsia, abdominal pain, increased activity of hepatic enzymes; infrequently - diarrhea, vomiting, stomatitis, glossitis, candidiasis mucous membrane of the oral cavity, acute pancreatitis, discoloration of tooth enamel and tongue, hepatocellular / cholestatic hepatitis, pseudomembranous colitis, cholestatic jaundice, anorexia, dryness of the oral mucosa, constipation, flatulence, belching, gastritis; extremely rare - liver failure with a fatal outcome mainly on the background of concomitant serious diseases and / or simultaneous prescription of other medicinal products;
• skin and subcutaneous tissue: often - hyperhidrosis; with an uncertain frequency - acne, drug rash (including with eosinophilia and systemic symptoms), erysipelas, erythrasma;
• nervous system: often - headache; infrequently - drowsiness, paresthesia, anxiety, convulsions, hallucinations, psychosis, confusion, dizziness, feeling of fear, nightmarish dreams, insomnia, depersonalization, tremor, disorientation, depression; with an uncertain frequency - a mania;
• urinary system: infrequently - interstitial nephritis; with an uncertain frequency - renal failure;
• allergic reactions: infrequent - skin itch / rash, skin hyperemia, urticaria, Stevens-Johnson syndrome (malignant exudative erythema), Lyell's syndrome (toxic epidermal necrolysis), anaphylaxis; with an uncertain frequency - purple Shenlaine - Genocha;
• laboratory data: infrequently - increased creatinine concentration, hypoglycemia (including when applied simultaneously with hypoglycemic drugs), increased activity alkaline phosphatase (AF), an increase in the level of bilirubin; with an uncertain frequency - an increase in the international normalized relationship (INR), prolongation of prothrombin time;
• Other reactions: secondary infections (development of resistance to microorganisms); infrequently, asthenia.

Overdose

It is not advisable to intentionally increase the dose prescribed by the doctor, as this may lead to an overdose of Clarithromycin. Clinical signs of macrolide overdose are expressed in the intensification of the side effects described above and the development of acute renal and hepatic insufficiency.

When accidentally ingesting a large number of Frohilid Uno tablets, the patient is washed with a stomach, given at least 6-8 tablets of Activated Carbon and left under observation. If necessary, symptomatic therapy is performed.

special instructions

Before you start using the drug, read the special instructions:

1. Among macrolide antibiotics, there is cross-resistance.
2. Most strains of Staphylococcus spp., Resistant to methicillin and oxacillin, are resistant to clarithromycin.
3. In the presence of chronic liver diseases, it is necessary to regularly monitor the activity of liver enzymes in the blood plasma.
4. With the simultaneous use of drugs metabolized in the liver, it is recommended to measure their concentration in the blood serum.
5. In the case of concomitant use with warfarin or other indirect anticoagulants, prothrombin time should be monitored.
6. If a severe and prolonged diarrhea occurs during or after treatment, the diagnosis of pseudomembranous colitis, which requires immediate withdrawal of the drug and the appointment of appropriate treatment.
7. Treatment with antibiotics changes the normal intestinal microflora, so there may be a superinfection caused by resistant microorganisms. When developing a secondary infection, adequate therapy should be prescribed.

Compatibility with other drugs

Due to the high pharmacological activity of clarithromycin, its drug interaction with a large number of drugs / agents is possible.

In the section "Contraindications" a list of drugs is given, a joint reception with which of whom is contraindicated, and the list medicines, joint therapy with which is conducted with caution and requires the supervision of a doctor.

Reviews

We offer you to familiarize yourself with the opinions of people who have used Framilid Uno:

1. Natalia. Fromelim recommended itself, in my experience, as a medicine that positively affects the treatment of stomach ulcers. My husband is constantly suffering from this disease and without fromilida sense in the treatment there. Earlier, about 6 years ago, took clarithromycin, now in our region it is not. But I'm even glad, because its action is much more effective. Several times they managed only with them, without the attendant medications. I, certainly, not the doctor, but also cured myself of them from a severe cold. So the medicine is very good.
2. Vlad. "Fromilide" was prescribed to me by a doctor when a left-sided sinusitis was diagnosed. I took 250 mg twice a day for seven days. In addition to taking an antibiotic, I went to the procedures of washing the nose "cuckoo". Since the drug has a side effect on the flora of the intestine, Bifiform and Fluconazole were assigned in parallel. At the end of the treatment period, progress was seen. I finished the course of the procedure and performed simple procedures for washing the nose at home. I also used vasoconstrictive drugs. The treatment was successful, the drug is worth its money. Personally, I believe that it is better to spend money and buy a medicine that guarantees recovery, rather than a long time to be treated with cheap antibiotics.

Analogues

Structural analogs for the active substance:

• Arvitsin;
• Arvitsin retard;
• Binocular;
• Zimbactur;
• Kispar;
• Klabaks;
• Clarcat;
• Clarithromycin;
• Clarithrosine;
• Claricin;
• Claricite;
• Claromin;
• Class;
• Clacid;
• Clerimedes;
• Coater;
• Crixan;
• Seidon Sanovel;
• CP Clarene;
• Fromromide;
• Ecositrin.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Store in the original packaging at a temperature of up to 25 ° C. Keep away from children.

Shelf life - 3 years.

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