Valvier

Valvir is a drug that belongs to the group of antiviral drugs with a rather narrow spectrum of action.

The active substance of the drug is valaciclovir hydrochloride hydrate. The drug works on a virus such as herpes - an infection caused by a cold, which is managed thanks to Valvir in just a few days. The medicine is quickly absorbed and is excreted through the kidneys.

On this page you will find all information about Valvir: the full instruction on the application for this medicine, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Valvir. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antiviral drug.

Conditions of leave from pharmacies

Available without a prescription.

Price list

How much does Valvir cost? The average price in pharmacies is at the level of800 rubles.

Form of issue and composition

Composition of 1 tablet:

active substance: valaciclovir - 500 or 1000 mg (valaciclovir hydrochloride hydrate - 611.7 or 1223.4 mg);

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additional components: povidone K30 - 24.5 / 49 mg, microcrystalline cellulose - 59.6 / 119.2 mg, magnesium stearate - 4.2 / 8.4 mg;
film shell: Opadry white Y-5-7068 (hypromellose 3cP - 7.35 / 14.7 mg, giprolose - 6.3 / 12.6 mg, dioxide titanium - 4.2 / 8.4 mg, macrogol / PEG 400 - 2.1 / 4.2 mg, hypromellose 50cP - 1.05 (2.1 mg) - 21/42 mg.

Form release: biconvex white tablets in a film shell of 500 and 1000 mg in a PVC blister № 7, 10, 14 in a cardboard package.

Pharmacological effect

The active component of the drug is quickly converted into L-valine and acyclovir under the specific action of valacyclovirhydrolase. Due to this, inhibitory activity to a number of viruses is observed: herpesvirus (1, 2, 6 type), cytomegalovirus, Varicella zoster. It is worth considering that Valvir is not an antibiotic, it does not have antimicrobial properties.

The mechanism of action is characterized by a violation of the process of DNA synthesis of pathogenic microorganisms. As a result of phosphorylation under the action of various kinds of enzymes, acyclovir is converted to acyclovir triphosphate. A short-term process of transformation of such a substance as acyclovir is completed by cellular kinases. Triphosphate compounds of acyclovir contribute to the destruction of DNA polymerase of viral cells, a gradual blocking of the distribution of herpesvirus occurs.

In some cases, low sensitivity of various herpesviruses to this drug is observed. This is due to a deficiency of thymidine kinase, which promotes the active spread of individual strains of viruses.

Indications for use

The drug is used for:

Treatment of herpes zoster, labial and simple herpes;
Prevention of the onset of herpetic and cytomegalovirus infections.

Contraindications

Absolute contraindications to the use of Valvira for the treatment of herpes are recognized several conditions:

Age before 12 years.
Pronounced HIV infection.
Bone marrow or kidney transplantation.

Very carefully, the drug is prescribed for pregnant and lactating women and patients with liver or kidney dysfunction.

Application in pregnancy and lactation

The experience of using the drug during pregnancy is not enough. The use of valaciclovir is recommended only if the therapeutic effect for the mother is higher than the possible risk to the fetus.

The Valvira Metabolite - acyclovir - is excreted in breast milk. Breastfeeding is allowed only when the effect of treatment for the mother is significantly higher than the estimated risk for the child.

Instructions for use

The instructions for use indicate that Valvir tablets are prescribed to adults inside.

With herpes zoster, 1000 mg 3 times a day for 7 days.
For the treatment of labial herpes, effective administration of the drug in a dose of 2 grams 2 times for 1 day: the second dose should be taken after about 12 hours (but not earlier, than after 6 h) after the first dose (do not apply this dosing regimen for more than 1 day, as, as shown, this does not provide additional clinical benefits).
With simple herpes - 500 mg 2 times / day. In case of relapse, the course should be 3 or 5 days. At the first episode with a heavy course duration of treatment can be increased up to 10 days (with relapses it is ideal to prescribe Valvier in the prodromal period or with the appearance of the first symptoms of the disease, i.e. tingling, itching, burning).
Prevention of infection with genital herpes of a healthy partner: an infected heterosexual adult with preserved immunity and with a number of exacerbations up to 9 per year appoint 500 mg 1 time / day for 1 year or more, every day with regular sexual activity, with irregular sexual intercourse reception Valvira it is necessary to start 3 days before the alleged sexual contact (data on the prevention of infection in other populations of patients are absent).
Prevention of recurrence of infections caused by the herpes simplex virus: in patients with preserved immunity - 500 mg 1 time / day; from very frequent relapses (10 and more per year) - 250 mg 2 times / day; for adult patients with immunodeficiency - 500 mg 2 times / day. The duration of the course is 4-12 months.
Prevention of cytomegalovirus infection: adults and adolescents over 12 years old - 2 grams 4 times / day (as soon as possible, after transplantation). The duration of the course is 90 days, but in patients at high risk, treatment may be longer.

The dose of Valvir should be reduced in patients with a significant decrease in renal function

Side effects

It should be noted that in some cases, patients may experience the following undesirable effects (against the background of taking the drug):

anaphylaxis;
impaired vision;
rashes on the skin, photosensitivity and itching;
hypercreatininaemia, lowering of hemoglobin;
angioedema and urticaria;
erythema multiforme;
discomfort in the abdomen;
dyspnea;
leukopenia and thrombocytopenia;
impaired kidney function;
Thrombocytopenic thrombotic purpura, neutropenia, aplastic anemia and leukoplastic vasculitis;
hallucinations, agitation, psychotic symptoms, dizziness, encephalopathy, agitation, confusion, depression, dysarthria, decreased mental abilities;
dysmenorrhea, respiratory tract infections, fever, tachycardia, dehydration, arthralgia, nasopharyngitis, fatigue, face swelling, increased pressure and rhinorrhea.

Also, patients complain of headaches and nausea. In addition, the medication often causes and quite serious negative phenomena in the form of acute renal failure, thrombotic thrombocytopenic purpura, neurological disorders and hemolytic-uremic syndrome.

Overdose

When a single dose of the drug to 20 g of toxic effect is not noted. With repeated intake of ultra-high doses for several days, there is a headache,nausea, vomiting, confusion.

special instructions

When there is side effects from the side of the central nervous system (delirium, hallucinations, convulsions), it is necessary to cancel the drug.

Long-term use of high doses of Valvir in conditions that are accompanied by severe immunodeficiency (bone marrow / kidney transplantation clinically expressed forms of HIV infection), can lead to hemolytic-uremic syndrome and the occurrence of thrombocytopenic purpura, up to a lethal outcome. Therapy is canceled in cases of adverse reactions from the central nervous system, including agitation, hallucinations, confusion, delirium, convulsions and encephalopathy.

If there is a probability of dehydration, especially in elderly patients, adequate hydration is required. An increased risk of developing neurological complications is noted in patients with renal insufficiency.

Drug Interactions

The study did not establish a clinically significant interaction of the drug with other drugs.

Reviews

We picked up some feedback from people about Valvir:

Oksana. Exacerbations of herpes from me periodically come from adolescence. I accept Valvir on the advice of an infectious disease specialist from the age of 18. Tablets I drink 3 r. per day for 1000 mg. The drug quickly removes itching and swelling and speeds up the healing process of the blisters. New items do not appear.
Alexander. The therapist prescribed kogacel propyl in the herpes zoster. Infectionist appointed valvir 7 days 3 r daily before this saw acyclovir tablets and ointment on blisters. And all this in a heap is not harmful and what consequences? pains are present the bubbles are not completely covered ...
Galina. Valvir with herpes helped me bring down the temperature, which lasted more than a week in the range of 37 - 37.7 ° C. Of the side effects, I note only drowsiness and light dizziness, but they did not influence overall performance.