Azaleptin

Azaleptin (international name Klozapin) is a drug designed to block receptors that participate in psychophysiological processes controlling human behavior.He is capable of putting in order the activity of the brain, the organization and stability of the neurological condition.

The agent interferes with the transmission of hormone production, which helps to break the connection between the auxiliary motor system and the bark of a large cerebral hemisphere, which actively participates in the metabolic processes of internal organs, emotions, sleep, and memory.

On this page you will find all information about Azaleptin: the full instructions for use on this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Azaleptin. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

An antipsychotic agent (neuroleptic), a derivative of dibenzodiazepine.

Conditions of leave from pharmacies

This remedy is given strictly according to the prescription.

Price list

How much does Azaleptin cost? The average price in pharmacies is at the level of250 rubles.

Form of release, composition and packaging

Tablets of 25 and 100 mg, 5 contiguous cell packs of 10 tablets or 50 tablets in a bank of light-protective glass, along with instructions for medical use in a pack of cardboard.

In 1 tablet of the drug contains the active substance: azaleptin (clozapine) - 25 mg or 100 mg, auxiliary substances: lactose monohydrate (sugar milk), potato starch, calcium stearate monohydrate.

pharmachologic effect

Azaleptin is an antipsychotic drug containing the active component of clozapine. Azaleptin differs from the "classical" neuroleptics. When taking clozapine, there was no development of catalepsy and depression of stereotyped behavior caused by the introduction of amphetamine and apomorphine. Azaleptin has a weak blocking effect on D1-3 and D5 receptors and a pronounced effect on D4 receptors. Clozapine has a pronounced anticholinergic, adrenolytic and antihistamine effect, inhibits the activation reaction and has a moderate antiserotonergic effect.

In clinical conditions, Azaleptin causes a pronounced and rapid sedative effect and a strong antipsychotic effect. The antipsychotic effect of clozapine is noted, including in patients with schizophrenia, resistant to therapy with other drugs. In such cases, clozapine is effective even with the productive symptoms of schizophrenia and with symptoms of prolapse.

Positive dynamics in patients with some cognitive disorders with clozapine is described. In patients with schizophrenia receiving Azaleptin, the incidence of suicide attempts and suicides is significantly reduced compared to patients who do not receive clozapine (in epidemiological studies, the incidence of suicide attempts in clozapine therapy decreased more than 7-fold compared with patients who did not receive clozapine.

Azaleptin practically does not affect the level of prolactin and, as a rule, is well tolerated by patients. Severe side effects with clozapine were noted only in isolated cases.

What helps with Azaleptin?

The main indications for the prescription of Azaleptin are such conditions / diseases:

1. Bipolar disorder;
2. Schizophrenia - a disease characterized by the decomposition of thinking;
3. In the alternation of psychoses of the manic and depressive phases with periods of well-being are diseases accompanied by unreasonable anxiety, anxiety, anger, absent-mindedness and mirth, accompanied by sleep disorders;
4. Counteract the body to other psychotropic drugs or their individual intolerance;
5. Manic conditions - pronounced optimism, excessively good mood, caused by diseases of the central nervous system or psychoses;
6. Also, the drug is prescribed for children with excessive emotionality, expressed by behavioral disorders.

The drug is indispensable for those suffering from schizophrenia, with depressive psychoses and sleep disorders, especially in cases where other drugs do not bring the desired effect. Although the improvement of well-being comes after the first intake, it is impossible to engage in self-medication.

Contraindications

The instructions to Azaleptin said that contraindications to taking the drug are:

• Personal intolerance to clozapine or ancillary components of the drug;
• Changes in blood parameters in the patient, especially associated with the administration of neuroleptics and tricyclic antidepressants;
• Myasthenia gravis;
• Toxic psychoses;
• Severe diseases of the cardiovascular system;
• Impaired liver and kidney function;
• Glaucoma;
• Epilepsy;
• Hypertrophy of the prostate;
• Atony of the intestine;
• Childhood.

During the course of treatment with the drug, you can not drive a car and potentially unsafe technique.

Pregnancy

Clozapine is contraindicated in pregnancy and lactation (breastfeeding).

Instructions for use Azaleptin

The instructions for use indicate that the dosage of Azaleptin is determined individually. For oral administration, a single dose of 50-200 mg, daily - 200-400 mg.

Treatment usually begins with a dose of 25-50 mg, then gradually increased by 25-50 mg per day to 200-300 mg / day for 7-14 days. The daily dose can be applied once before bedtime or 2-3 times / day after eating. If you cancel treatment, you should gradually reduce the dose within 1-2 weeks. After reaching a therapeutic effect, they switch to a supportive course.

1. If necessary, clozapine can be administered in / m.
2. The maximum dose for ingestion is 600 mg / day.

For mild forms of the disease, for maintenance therapy, as well as for patients with hepatic and / or renal insufficiency, chronic heart failure, cerebrovascular disorders are prescribed at lower daily doses (25-200 mg)

Side effects

Long-term, uncontrolled use of the drug, with non-compliance with the recommended dosages and the frequency of admission in patients may occur:

1. On the part of the digestive system: dry mouth or hypersalivation, vomiting, heartburn, nausea, abdominal discomfort, constipation, increased activity of liver enzymes and cholestasis.
2. From the side of the central nervous system: drowsiness, severe fatigue, dizziness, severe headache, extrapyramidal symptoms (mild), rigidity, tremor, akathisia or the development of a malignant neuroleptic syndrome.
3. Metabolic disorders: hyperglycemia and weight gain with the formation of obesity, gynecomastia.
4. On the part of the hematopoiesis system: agranulocytosis and granulocytopenia, eosinophilia and leukocytosis of unknown nature (in the first weeks of treatment).
5. Allergic reactions: in the form of skin rashes, pigmentation, urticaria, erythema multiforme, photosensitivity and exfoliative dermatitis.
6. From the cardiovascular system: arterial and / or orthostatic hypotension with dizziness, tachycardia, arrhythmia. In rare cases - a collapse with oppression or stopping breathing, changes in the ECG, the development of cardiomyopathies, myocarditis and pericarditis.

It is also possible to disrupt accommodation, develop hyperthermia, urination disorders, thermoregulation and sweating.

Overdose

Overdose Azaleptin is dangerous because poisoning can occur. Its symptoms are stunnedness, drowsiness, increased anxiety, tachycardia, collapse, difficulty breathing, coma, epileptic seizures, hypotension. When an overdose is provided, the use of sorbents, the maintenance of respiratory and cardiac functions, as well as symptomatic treatment.

special instructions

The development of granulocytopenia requires immediate discontinuation of the drug.

For the period of application of this drug should be excluded the use of alcohol-containing beverages.

During the treatment with Azaleptin, care must be taken when managing transport and working with complex mechanisms requiring increased concentration of attention.

Reviews

Positive reviews of Azaleptin indicate that this tool is very effective in acute attacks of schizophrenia. In addition, doctors say that it helpsmanic states, unproductive mania with delirium, as well as classical andatypicalmania. On the forums reviews on Azaleptin in regard to its positive effects whenmanic-depressive psychosisand variouspsychotic diseases, certainly positive.

Nevertheless, take this medication with caution, since the risk of side effects in case of overdose or improper combination with other drugs is high. So the question of whether to release Azaleptin by prescription or not, in fact, is not worth it. Without the supervision of a specialist, it is strictly not recommended to use this remedy.

Analogues

Structural analogs for the active substance:

• Azaleprol;
• Clozapine;
• Klozasten;
• Leponeks.

Before using analogues, consult your doctor.

Terms and conditions of storage

The drug should be stored for no more than 3 years in a place inaccessible to children, since poisoning with Azaleptin is very dangerous. The temperature regime in the room should be maintained at 15-30 ° C.

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