Yunidox Solutab

Unidox Solutab is a representative of the group of semisynthetic antibiotics-tetracyclines, characterized by a wide spectrum of antimicrobial activity. The Latin name of the drug is Unidox Solutab.

This drug has a pronounced anti-inflammatory and bacteriostatic clinical effects. Unidox Solutab is used in the field of modern medicine to combat diseases, the emergence of which is associated with the pathological activity of pathogenic microorganisms possessing sensitivity to doxycycline.

The most sensitive to Unidox in our time among Gram-positive cocci are pneumococcus, most enterococci and some groups of staphylococci, from gram-negative - moraxella and meningococci. Most gonococci are insensitive. The activity of doxycycline in relation to leptospira, rickettsia, spirochetes, chlamydia, borrelia, mycoplasma, some protozoa and actinomycetes is noted.

Clinical and pharmacological group

Semisynthetic antibiotic of the group of tetracyclines of wide spectrum of action.

Terms of sale from pharmacies

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Can buyby prescription.

Price

How much does Unidox Solutab cost in pharmacies? The average price is at the level of350 rubles.

Composition and form of release

The drug Unidox Solutab is available in the form of dispersible (soluble) biconvex tablets of circular shape. The color can be different shades of yellow. On one side of the tablet, a notch is visible, on the other side is engraved "173".

One tablet of the drug contains 0.1 g of doxycycline antibiotic + auxiliary substances (MCC, giprolose, saccharin, colloidal silicon dioxide, lactose monohydrate, hypromellose, magnesium stearate).

Tablets are packaged in plastic blisters of 10 pieces, one each in a cardboard package.

Pharmacological effect

Unidox is a semisynthetic tetracycline with a broad spectrum of action, which has a bacteriostatic effect. The drug is able to affect the pathogens located inside the cell. According to reviews, Unidox has high sensitivity Gram-positive (staphylococcus aureus, streptococcus, clostridia, listeria) and gram-negative (Neisseria, Haemophilus influenzae, Klebsiella, Escherichia coli, Shigella, Enterobacter, Salmonella, Yersinia, Treponema) microorganisms.

The drug is inactive against fungi and most strains of Pseudomonas aeruginosa and Proteus. The instructions to Unidox indicate that this drug in comparison with other tetracyclines has a longer action and higher therapeutic activity.

Indications for use

The drug Unidox Solutab has found wide application in the treatment of such diseases as:

STIs (sexually transmitted infections) - gonorrhea, syphilis, venereal lymphogranuloma, inguinal granuloma;
chlamydial infections - trachoma, urethritis, cervicitis, psittacosis, prostatitis;
Mycoplasma infections;
pink acne (rosacea);
acne disease;
borreliosis - recurrent typhus, Lyme disease;
bacterial zoonotic infections - tularemia, plague, brucellosis, anthrax, leptospirosis;
rickettsiosis;
infection of the lower respiratory tract - community-acquired atypical pneumonia, chronic bronchitis in the acute stage;
gynecological infectious diseases - salpingoophoritis, adnexitis, endometritis;
actinomycosis;
acute dacryocystitis;
intestinal infectious diseases - yersiniosis, cholera;
bites of animals complicated by wound infection;
cat scratch disease;
prevention of tropical malaria.

Contraindications

age group of patients up to 8 years;
pregnancy and GK period;
acute form of renal and / or liver failure;
increased susceptibility of the patient to tetracyclines.

Intended use for pregnancy and lactation

Pregnant and lactating women are not allowed to use this medication. If it is necessary to use during the GW period, the baby should immediately stop breastfeeding.

Dosage and route of administration

As indicated in the instructions for use Unidox Solutab is preferably taken with meals. The tablets are dissolved in a small amount of water (about 20 ml) to obtain a suspension. Tablets can also be swallowed whole, divided into parts or chewed, washed down with water. Usually the duration of treatment is 5-10 days.

Adults and children older than 8 years with a body weight of more than 50 kgon the first day of treatment, 200 mg per day in 1 or 2 doses, in the following days of treatment - 100 mg per day in 1 dose. In the case of severe infections, 200 mg per day are administered throughout the treatment period.

For children aged 8-12 years with a body weight of less than 50 kgthe average daily dose is 4 mg / kg on the first day, then - 2 mg / kg per day (in 1-2 divided doses). In cases of severe infections, the drug is prescribed at a dose of 4 mg / kg daily throughout the treatment.

When acne is prescribed for 100 mg per day, the course of treatment is 6-12 weeks.
For the prevention of malaria appoint 100 mg once a day for 1-2 days before travel, then - daily in time of travel and within 4 weeks after return; children older than 8 years - 2 mg / kg 1 time per day.
To prevent travel diarrhea - 200 mg on the first day of travel in 1 or 2 admission, then - 100 mg once a day during the stay in the region (not more than 3 weeks).
With infection caused by Streptococcus pyogenes, the duration of treatment is at least 10 days.
With uncomplicated gonorrhea (with the exception of anorectal infections in men), adults are prescribed 100 mg twice a day until they are completely cured (on average for 7 days), or within one day, 600 mg are prescribed - 300 mg in 2 divided doses (the second reception 1 hour after the first).
When primary syphilis is prescribed for 100 mg twice a day for 14 days, with secondary syphilis - 100 mg 2 times a day for 28 days.
In uncomplicated urogenital infections caused by Chlamydia trachomatis, cervicitis, non-gonococcal urethritis caused by Ureaplasma urealiticum, 100 mg are administered twice a day for 7 days.
For treatment of leptospirosis - 100 mg orally 2 for 7 days; for the prevention of leptospirosis - 200 mg once a week during a stay in a dysfunctional area and 200 mg - at the end of the trip.
To prevent infections, medical abortion is prescribed 100 mg per hour before and 200 mg after the intervention.

Maximum daily doses for adults- up to 300 mg per day or up to 600 mg per day for 5 days with severe gonococcal infections. For children older than 8 years with a body weight of more than 50 kg - up to 200 mg, for children 8-12 years with a body weight of less than 50 kg - 4 mg / kg daily for the entire treatment.

In renal (KK less than 60 ml / min) and / or liver failure, a daily dose of doxycycline is required.

Adverse Reactions

Antibiotic Yunidox Solutab is able to negatively affect the body. The instruction to the preparation contains information on the development of a number of side effects:

Lesions of the liver and kidneys.
The emergence of superinfection (development of candidiasis).
Long-term antibiotic therapy often causes the onset of dysbacteriosis and its consequence - hypovitaminosis.
Disturbances of the digestive tract, expressed in attacks of nausea, vomiting, loss of appetite, development of enterocolitis, diarrhea, pseudomembranous colitis.
Manifestations of allergic, dermatological reactions (dermatitis, hives, photosensitization). In the presence of individual intolerance, taking antibiotics can provoke Quincke's edema.
Changes in the picture of blood (neutropenia, thrombocytopenia).
The appearance of malfunctions in the activity of the central nervous system (dizziness, vestibular pathologies, headaches, drowsiness, edema of the optic nerves).

The active component of the drug slows down osteogenesis, adversely affects the development of the teeth of small patients (negative the effect is expressed in the irreversible change in the color of the enamel, congenital malformations of the underdevelopment of the tissues of the bone formations).

Overdose Symptoms

Symptoms of overdose with high doses of Unidox Soluteb are:

diarrhea;
fits of vomiting;
anorexia;
feeling dizzy;
nausea;
pain in the head.

If there are signs of intoxication, you should immediately take a sufficient number of enterosorbents, rinse the stomach and start symptomatic treatment.

special instructions

Before you start using the drug, read the special instructions:

Doxycycline solution for intravenous administration should be used no later than 72 hours after its preparation.
With care apply doxycycline in case of violations of the liver. With violations of kidney function, dose adjustment is not required.
To prevent locally irritating action (esophagitis, gastritis, ulceration of the gastrointestinal tract), it is recommended to take in the daytime hours with lots of liquid, food or milk. In connection with the possible development of photosensitization, it is necessary to limit the insolation during treatment and for 4-5 days after it.
Doxycycline is not used in children under 8 years of age. tetracyclines (including doxycycline) cause a long-term change color of teeth, hypoplasia of enamel and slowing of longitudinal growth of bones of the skeleton in this category of patients.

Compatibility with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

Simultaneous use of retinol helps increase intracranial pressure.
Absorption of doxycycline reduces colestyramine and colestipol (observe the interval between taking at least 3 hours).
In connection with the suppression of the intestinal microflora, doxycycline decreases the prothrombin index, which requires correction of the dose of indirect anticoagulants.
The use of doxycycline reduces the reliability of contraception and increases the frequency of breakthrough bleeding when taking estrogen-containing oral contraceptives.
Preparations containing metal ions (antacids, preparations containing iron, magnesium, calcium) form with doxycycline inactive chelates, in connection with which it is necessary to avoid their simultaneous appointment.
When used simultaneously with barbiturates, carbamazepine, phenytoin, the concentration of doxycycline in the blood plasma is reduced in connection with the induction of microsomal enzymes of the liver, which may be the reason for reducing its antibacterial action.
It is necessary to avoid combination with penicillins, cephalosporins, which have bactericidal action and are antagonists of bacteriostatic antibiotics (including doxycycline).

Patient Reviews

We suggest you read the reviews of people who used Unidox Solutab:

Julia. My dermatologist appointed Unidox from acne, which I could not in any way bring out, neither Clarusil, nor hormonal and contraceptive, everything went in the way, until finally they decided that my comedones are of an infectious nature and I had to just drink special antibiotics, which was Unidox.
Valya. Nauseated me from it, especially in the early days, but I was afraid to quit, antibiotic all the same. And in general with a sore he has consulted. I used it for the treatment of cystitis. The previous time, another antibiotic drank, but it seems he did not work so well, a couple of months later there was a relapse. And after that, for more than a year cystitis did not return t-t-t ..
Andrei. The doctor appointed Unidox together with the Tiburan course in 10 days. I was only enough for a half-course - 5 days. Headaches, fever, muscles ached like after a gym, weakness. And the most terrible thing is that my eyes ached with the intracranial pressure, even the blinking was painful. Symptoms of all these were only a day after the abolition of drugs. I do not know what the matter is or the combination of drugs is unsuccessful or on Tiberal such a reaction (I drank it for the first time), but it was physically impossible to complete the full course of such treatment. I used to drink plain Doxycycline, no side-effects ever happened!

Analogues

Instead of Yunidox Solutab, the following drugs can be used:

Xedocin is a German drug, which is a complete analogue of the drug Unidox Solutab. Antibiotic is produced in capsules, contraindicated for children under 8 years old, patients in the position and breast-feeding.
Doxycycline is a domestic drug that is produced by a number of Russian companies. On sale, it is in capsules (allowed to patients over 12 years old, whose weight is more than 45 kg) and lyophilizate from which the infusion solution is prepared (can be from 8 years). Antibiotic is contraindicated in pregnant and lactating women.
Vidoksin - a domestic medication based on doxycycline, which is produced in lyophilizate while diluting it, produces a solution for intravenous administration. The medicine is prohibited for children under 8 years old, pregnant and lactating.
Minolexin is a substitute for the drug Unidox Solutab by the pharmacological group. An antibiotic is released in capsules that are allowed for children older than 8 years old, pregnant patients. It is recommended to stop breastfeeding while taking the medication.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

The medication should be stored in a dry, dark place at a temperature not exceeding 25 degrees. It is necessary to limit access of children to the drug.

Shelf life - 5 years.