Siofor

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Siofor is one of the most popular hypoglycemic drugs. The main active ingredient is metformin substance.

He is appointed to effectively regulate the amount of concentrated glucose in insulin-dependent diabetics.

The remedy is irreplaceable in case proper nutrition and regular exercise do not help in the fight against weight gaining glycemia. No less important advantage of the drug is its ability to effectively reduce the amount of cholesterol, and it also appears to be a unique help in the fight against excessive weight.

Clinical and pharmacological group

Oral hypoglycemic drug.

Terms of sale from pharmacies

It is possible to buy under the prescription of the doctor.

Price

How much is Siofor 500 mg in pharmacies? The average price is at the level of280 rubles.

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Composition and form of release

Dosage form - tablets, coated with a white coating:

  • Siofor 500: round, biconcave (10 pcs. Each). in blisters, in a cardboard bundle of 3, 6 or 12 blisters);
  • Siofor 850: oblong, with a two-sided risk (15 pcs. in blisters, in a cardboard bundle of 2, 4 or 8 blisters);
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  • Siofor 1000: oblong, with a risk on one side and a wedge-shaped depression "snap-tab" on the other (15 pcs. in blisters, in a cardboard bundle of 2, 4 or 8 blisters).

The active substance of the drug is metformin hydrochloride, in one tablet it contains 500 mg (Siofor 500), 850 mg (Siofor 850) or 1000 mg (Siofor 1000).

Additional components:

  • Excipients: povidone, hypromellose, magnesium stearate;
  • Sheath composition: macrogol 6000, hypromellose, titanium dioxide (E171).

pharmachologic effect

Siofor is a product from Berlin-Chemie AG. This is one of the largest pharmaceutical associations located in Italy. Produce the drug in the form of tablets of different dosages. It can be Siofor 500, 850 and 1000 mg.

The basic substance of the drug has no effect on the functioning of human beta cells. Due to this, the body does not produce a large amount of insulin, therefore, hypoglycemia does not develop. The positive effect of the drug is based on the additional components that make up the medicine, among which are Povidone, Magnesium stearate, Titan dioxide, Gipromelase and Macrogol 6000.

The unique composition of the medicinal product enables the people taking it to achieve such positive results as:

  1. Deceleration of absorption of active glucose in the digestive organs;
  2. Decreased rate of glucose production in the liver;
  3. Improve the overall sensitivity of peripheral tissues to sugar-containing hormones.

Siofor in the treatment of diabetes has a positive effect on the overall lipid metabolism, significantly improves coagulability of the blood. The amount of sugar in the body decreases during food intake, but before meals.

Patients who take the medicine and adhere to a simple diet quickly achieve weight loss.

Indications for use

The drug is recommended for use in the treatment of type 2 diabetes, especially in overweight patients with no effect from physical exertion and therapeutic diets.

Siofor can be used as a monotherapy or in combination with other oral hypoglycemic agents and insulin.

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Contraindications

Absolute:

  • Diabetic ketoacidosis, diabetic precoma;
  • Lactacidosis, including in the anamnesis;
  • Liver failure;
  • Intravascular injection of iodine-containing contrast medium;
  • Compliance with a low-calorie diet (consumption of less than 1000 kcal per day);
  • Children under 10 years;
  • Pregnancy;
  • Lactation period;
  • Impaired renal function (creatinine clearance ≤ 0 ml / min) or kidney failure;
  • Acute conditions that can have a negative effect on kidney function (eg, severe infectious disease or dehydration);
  • Chronic alcoholism and acute alcohol intoxication;
  • Acute or chronic diseases that can lead to tissue hypoxia (eg, respiratory or heart failure, recent myocardial infarction, shock);
  • Hypersensitivity to the components of the drug.

Relative (special care is required):

  • Children aged 10-12 years;
  • Patients over the age of 60 years who perform heavy physical work.

Intended use for pregnancy and lactation

Pregnancy is a contraindication for taking Siofor. The drug is contraindicated during pregnancy. When planning pregnancy, treatment with the drug is also not recommended.

Dosage and route of administration

As indicated in the instructions for use, the Siofor 500 tablet is taken orally during or after a meal. Mode of admission, the dose of the drug, the duration of the course of therapy the doctor appoints individually, taking into account the level of glucose concentration in the blood plasma.

Recommended dosing for adults:

  1. Monotherapy: the initial dose - 1 pc. (, g) 1-2 times a day for 10-15 days. Then, taking into account the level of glucose in the blood plasma, the dose is gradually increased to 3-4 pieces. in a day. Gradual increase of the dose allows to avoid symptoms of intolerance from the gastrointestinal tract. The maximum daily dose is 6 pcs. (3 g) divided into 3 doses;
  2. Combination therapy with insulin: the initial dose - 1 pc. 1-2 times a day. The dose should be increased gradually, with an interval of 7 days. The average daily dose after the increase - 3-4 pcs. The dose of insulin is determined based on the level of glucose in the blood. The daily dose of the drug should not exceed 6 pcs., It should be divided into 3 doses.

The transition from the use of another antidiabetic drug is done by canceling the previous and immediate start of the administration in the above doses of Siofora 500.

For patients in old age, the dose of the drug should be administered with extreme caution, only taking into account the level of creatinine in the blood plasma. Treatment should be under regular monitoring of the state of kidney function.

Recommended dosing Siofor 500 for children over 10 years with monotherapy and combination with insulin: the initial dose is 1 pc. (, g) 1 time per day. To achieve the desired therapeutic response after 10-15 days of admission, you can begin to gradually increase the dose, depending on the level of glucose in the blood plasma. The maximum daily dose for children aged 10 to 18 years is 4 pcs. (2 g of metformin) in 2-3 doses. The dose of insulin is determined based on the level of glucose in the blood plasma.

With the appointment of 4-6 pcs. (2-3 g) per day, you can use the drug tablets at a dose of 1 g (Siofor 1000).

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How to take Siofor 500 for weight loss

The minimum dosage of metformin, which is possible for Siofor (according to the assortment of Russian pharmacies) is 500 mg. The use of such a pill is allowed even in children, and individuals who are considering the option of losing weight with Siofor, it is desirable to do this option. In diabetics, doctors suggest two options for using the drug:

  • as monotherapy - 500 mg 2 times per day;
  • combined with insulin (with a dependence) - an increase from 500 mg to 2000 mg per day, i.e. from 1 to 4 receptions.

If you say how to take Siofor 500 for weight loss, then it is desirable to stop at proposed by the official instruction version of monotherapy: during the month to drink tablets Siofor 500 for 1 pc. in a day. Do this with food or after its reception, tk. the use of metformin is fraught with irritation of the gastrointestinal tract. The minimum dosage of Siofor on the process of losing weight affects gently, but the side reactions to it - a rarity. With good tolerability, the instruction permits an increase in the dose to 2 tablets of Siofor.

Side effect

Possible violations (often ≥ 1/100, <1/10, infrequently - ≥ 1/1000, <1/100, rarely - ≥ 1/10 000, <1/1000, very rarely - <1/10 000, s specific cases):

  • nervous system: often - a violation of taste;
  • allergic reactions: very rarely - skin reactions, including flushing, itching, hives;
  • digestive system: nausea, vomiting, lack of appetite, metal taste in the mouth, abdominal pain, diarrhea. These adverse reactions most often develop at the beginning of the course, then, as a rule, they pass by themselves. To reduce the likelihood of these disorders, it is recommended to divide the daily dose by 2-3 times, take Siofor during or after meals and increase the dose gradually;
  • metabolism: very rarely - laktatsidoz (with the development of this violation, the drug is canceled); at a long course - decrease in absorption of vitamin B12 and its plasma concentration in the blood (should be considered in the presence of megaloblastic anemia);
  • liver and biliary tract: individual cases - violations of the liver's reversible character, which are expressed as an increase in the activity of hepatic transaminases, hepatitis.

Overdose

If there is a significant drug overdose, there is a risk of developing lactic acidosis, the signs of which are respiratory disorders, nausea, severe weakness, drowsiness, vomiting, abdominal pain, diarrhea, hypothermia, reflex bradyarrhythmia, a decrease in blood pressure. Also, confusion and loss of consciousness, pain in the muscles are possible.

To eliminate the symptoms of an overdose, it is recommended to take glucose or foods rich in carbohydrates. It is necessary to cancel the drug and hemodialysis.

special instructions

Standard laboratory tests for patients with diabetes should be carried out regularly.

Before using Siofor in children aged 10 to 18 years, it is necessary to confirm the diagnosis of type 2 diabetes.

Since metformin is excreted by the kidneys, it is necessary to determine the concentration of creatinine in the blood plasma before starting treatment, and then regularly. Particular care should be taken in cases where there is a risk of impaired renal function, for example, at the beginning of therapy with antihypertensive drugs, diuretics or NSAIDs.

Treatment with Siofor should be temporarily replaced with other hypoglycemic drugs (for example, insulin) 48 hours before and 48 hours after the X-ray examination with intravenous administration of iodine-containing contrast substances.

The use of Siofor should be discontinued 48 hours before the planned surgical operation under general anesthesia, with spinal or epidural anesthesia. Continue therapy should be after the resumption of oral nutrition or no earlier than 48 hours after surgery, subject to confirmation of normal renal function.

Siofor does not replace the diet and daily exercise - these types of therapy must be combined in accordance with the recommendations of the doctor. During treatment with Siofor, all patients should adhere to a diet with a uniform intake of carbohydrates throughout the day. Patients with excessive body weight should follow a low-calorie diet.

During one-year controlled clinical trials, the effects of metformin on growth and development, as well as the puberty of children was not observed, the data on these indicators with a longer application are absent. In this regard, careful monitoring of the relevant parameters in children receiving metformin is recommended, especially in the prepubertal period (10-12 years).

Monotherapy with Siofor does not lead to hypoglycemia, but caution should be exercised when using the drug simultaneously with insulin or sulfonylurea derivatives.

Lactacidosis is a serious pathological condition, which is extremely rare, associated with the accumulation of lactic acid in the blood, the cause of which can be the cumulation of metformin. The described cases of lactic acidosis in patients receiving metformin were observed mainly in patients with diabetes mellitus with severe renal insufficiency. Prevention of lactic acidosis involves the identification of all associated risk factors, such as decompensated diabetes, ketosis, prolonged fasting, excessive alcohol consumption, liver failure and any condition associated with hypoxia. If the suspected development of lactic acidosis is recommended immediate withdrawal of the drug and emergency hospitalization.

The use of Siofor does not cause hypoglycemia, therefore does not affect the ability to drive vehicles and service mechanisms.

With the simultaneous use of Siofor with other hypoglycemic drugs (derivatives of sulfonylureas, insulin, repaglinide), hypoglycemic conditions may develop, therefore, care must be taken when driving vehicles and other potentially hazardous activities requiring concentration of attention and speed of psychomotor reactions.

Interaction with other drugs

During treatment with Siofor, it is not recommended to take drinks or preparations containing ethanol, because of aggravation risk of lactic acidosis (especially against a background of eating disorders, diet or liver insufficiency).

Combinations of metformin with other drugs, which require special care due to possible interaction reactions:

  • Angiotensin converting enzyme (ACE) inhibitors and other antihypertensive drugs - it is possible to reduce blood glucose levels;
  • Derivatives of sulfonylureas, acarbose, salicylates, insulin - increased hypoglycemic effect;
  • Diuretics, beta-adrenomimetics, glucocorticoids (for systemic and topical administration) - the level of glucose in the blood increases;
  • Indirect anticoagulants - their action is weakened;
  • Cimetidine - Metformin excretion is slowed down, the risk of lactic acidosis is aggravated;
  • Cationic preparations (quinidine, procainamide, morphine, amiloride, vancomycin triamterene, ranitidine), secreted in the tubules - the maximum plasma concentration of metformin increases;
  • Danazol - may develop a hyperglycemic effect (may require a change in the dose of Siofor);
  • Nifedipine - increases the maximum concentration and absorption of metformin in the plasma, lengthening its excretion;
  • Derivatives of phenothiazine, epinephrine, thyroid hormones, glucagon, nicotinic acid, oral contraceptives - increases the concentration of glucose in the blood;
  • Furosemide - reduces its concentration and half-life.

Reviews

We offer you to read reviews of people who used the drug Siofor:

  1. Inna. Serious difference between Siafor 1000 and Siafor 500, I did not see, I drank both options. Each of 1 tablet, the course was two weeks. Although a low dosage, though high, the effect is one - a terrible training of willpower! When you try to eat cookies, vomiting begins, because the drug blocks carbohydrates. My husband acts the same way, but I sinned on my body.
  2. Elena. My dear women. After birth, my weight was 140 kg and my doctor prescribed me Siofor 1000 plus hormones. For four months minus 45 kg of side effects there was no metabolism normalized. But the minus in what when they stop to drink weight can be typed quickly be cautious. It took two years, my weight is now 73 kg. The tablet does not take to age to control the weight all well... I'm very glad that I learned about these tablets.
  3. Victoria. I accept 3 weeks. The doctor appointed because of polycystic ovaries and high levels of insulin. Terrible side effects: nausea, headache (buzz), weakness, lethargy, abdominal pain. The first week, nothing came into my mouth. Then she started to eat slowly. But again yesterday I returned to the fact that nothing climbs (except for fruit and tomato with cucumbers). But there are pros: sensitivity to sweet - everything seems so sweet that it is disgusting to eat (bananas generally seem like sugar made). There is no desire to eat something flour or cereal (it seems tasteless). Fat at all I do not eat, as it tears from it (but this is from times when the gallstone was removed). And losing weight.. is 200 grams per day, and there are 3 kg.. And no physical exertion.. because there is no strength just.. I want to lie all the time: (((

Analogues

A full replacement in the treatment of diabetes and fluctuations in sugar by the point of the active substance and the general provisions of the instruction doctors call only 2 drugs:

  • Metformin.
  • Glucophage.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Tablets should be stored out of reach of children at a temperature of not more than 25 degrees. Shelf life of the medicine is 3 years from the date of manufacture, indicated on the package.


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