What helps Mezim forte: the instruction and analogues

Mezim forte is a digestive enzyme preparation that compensates for "flaws" in the exocrine activity of the pancreas.

This drug from the German pharmaceutical company Berlin Chemie is one of the leaders in its competitive group for total sales. It is indicated for use in chronic diseases of the digestive system, in particular the intestine and pancreas.

It is prescribed for permanent use by patients who underwent surgical removal of the stomach or who were on radiotherapy for oncological processes in the digestive organs.

Clinical and pharmacological group

Enzyme preparation.

Conditions of leave from pharmacies

Released without a doctor's prescription.

Price list

How much does Mezim forte? The average price in pharmacies is at the level of90 rubles.

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Form of issue and composition

Mezim forte is manufactured in the form of coated tablets: flat-cylindrical, with beveled edges and almost plane-parallel surfaces, pink, with a characteristic odor of pancreatin (by 20 pcs. in blisters, 1, 2, 4, 5 blisters in a cardboard bundle).

The composition of 1 tablet includes pancreatin with minimal enzymatic activity:

• Amylase - 4200 ED Ph. Eur;
• Lipases - 3500 ED Ph. Eur;
• Protease - 250 units Ph. Eur.

Auxiliary components: microcrystalline cellulose, sodium carboxymethyl starch (type A), colloidal silicon dioxide, magnesium stearate.

Sheath composition: talc, hypromellose, azorubin varnish (E122), 30% simethicone emulsion (as a dry mass), titanium dioxide (E171), 30% dispersion of polyacrylate (as dry mass), macrogol 6000.

Pharmacological effect

The main active ingredient of the drug is pancreatin, which contains lipase, trypsin, chymotrypsin and amylase, which are actively involved in the digestion of basic energy sources like fats, carbohydrates and proteins.

Due to their participation, the pancreas loads are reduced. Pancreatin is not absorbed into the tissues, but is excreted with dead masses. The main part of the substance is split in the digestive canal under the influence of intestinal bacteria and digestive enzyme substances.

The main purpose for the therapeutic effectiveness of the drug is the lipolytic activity of the basic active substance and the presence of trypsin, and amylase activity is important only in patients with cystic fibrosis.

Indications for use

Indications for the use of Mezim forte are diseases that involve a high burden on the pancreas and diseases of the gland itself, which, respectively, are associated with its dysfunction.

This drug is prescribed for the following pathologies:

1. Cystic fibrosis;
2. When preparing a patient for the study of the gastrointestinal tract (ultrasound, radiological study);
3. When conducting surgery in the intestine or stomach;
4. Chronic inflammation of the pancreas;
5. With increased gas production and flatulence;
6. With a digestive disorder;
7. When you take fried and fatty foods;
8. When infectious lesions of the gastrointestinal tract.

Taking Mezim in these conditions significantly improves the general condition of the patient.

Contraindications

Before using the drug, you should carefully study the instructions, as Mezim forte has some limitations and contraindications:

• Individual hypersensitivity to the constituents of the preparation;
• Exacerbation of pancreatitis or other chronic diseases of the gastrointestinal tract;
• Acute pancreatitis.

Use in pregnancy and lactation

Designed for Mezim, the instructions for use allow the use of the drug during pregnancy. However, doctors advise to resort to treatment only in extreme cases, when the benefits for the mother are higher than the possible risks for the fetus to be born. If side effects occur, enzymes should be discontinued immediately.

During breastfeeding, it is not forbidden to drink enzymes.

Dosage and route of administration

The instructions for use indicate that the dose of Mezim forte is determined individually, depending on the degree of digestion disorders.

• Adults: 1-2 tablespoons. before eating, without chewing and washing down with water. If necessary, additionally during a meal take another 1-4 tablets.
• In children, the drug is used as directed by a doctor.

Duration of treatment can vary from several days (if the digestive process is disturbed due to inaccuracies in the diet) up to several months or years (if necessary, therapy).

Side effects

There was no development of side effects or complications, even with prolonged and regular use of Mezim forte 10000 in patients with impaired pancreatic function.

In some cases, after the administration of pancreatin, allergic reactions may develop, rarely diarrhea or constipation, nausea, discomfort in the epigastric region. In single cases in patients suffering from cystic fibrosis, with prolonged use of high doses of the drug possible development hyperuricosuria (increased uric acid level in the blood plasma), the formation of strictures in the ileocecal region and ascending colon.

Overdose

There were no cases of overdose in patients treated with Mezim forte, however, with its uncontrolled use in overestimated doses, the subsequent development of adverse events on the part of the gastrointestinal tract, namely, nausea, stomach pain, vomiting, chair.

special instructions

To wash Mezim Forte is better than usual drinking water, than juice or tea. Tablets should be taken sitting or standing, within three to four minutes after ingestion, one should not lie down, as this can cause the tablet shell to collapse in the esophagus without getting into the stomach.

With the simultaneous use of other medications, Mezim Forte should be taken no sooner than 5-15 minutes after or before taking other medications.

Drug Interactions

With the simultaneous use of pancreatin with iron preparations, it is possible to reduce absorption of the latter.

Simultaneous use of antacid agents containing calcium carbonate and / or magnesium hydroxide can lead to a decrease in the effectiveness of pancreatin.

Reviews

We picked up some reviews of people taking the drug Mezim forte:

1. Julia. I use Mezim Forte on every holiday, it is simply irreplaceable for me. I heard that it can be replaced by other analogues, but no drug helps me as much as Mezim Forte. I take it after overeating and literally after 20 minutes the weight from the stomach goes away, the food is quickly digested. Of the shortcomings, I can only name its high price, but I try not to pay special attention to this. There have been cases when I forgot to take this drug with me on holiday, then you should either eat moderately or be in such a state that you can not dance.
2. Elena. Sometimes I have abdominal pain, more often when I start eating "horrible I break the diet, overeat, well, or eat something too fat or heavy. Something seems to me that these symptoms and the situation is familiar to many, I'm not the only one. In such cases, I accept Mezim. This drug was prescribed to me by a doctor, although I know many people who take it on their own without a doctor's appointment. I will not say it right or not. But of course you can not take it uncontrollably. This is a fermented drug that helps me digest food more quickly. The pills themselves are so pink, not very large, but not small. Take them all you need, and drink a glass of water preferably. Tablets do not dissolve in the stomach, but act immediately in the intestine, so they work faster. They are not very expensive. And for many years have proved their effectiveness.
3. Michael. Familiar to me a long time ago, a drug that is so much advertised on TV. It is sold almost everywhere, where it can be done, the prices are not very expensive. As a medicine, it basically helps. The pain in the stomach takes off in a few hours. And it is recommended to drink them all day 2, during this time the pain will pass. I recommend, if you have not found analogs in your pharmacies.

Analogues

In the market of pharmaceutical products a wide range of enzyme additives is presented. They are similar in composition, differing only in the amount of amylase and excipients. Medicines of this group are intended for restoration of processes of digestion, maintenance of function of the gastrointestinal tract of people leading a low-activity lifestyle, so always have to be at home first-aid kit.

The main Mezim counterparts are:

• Pancreatin;
• Festal Fort;
• Creon 10000;
• Gastenorm forte;
• Enzistal;
• Panzinorm;
• Vestal.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Tablets should be kept in their original packaging in a cool dark place out of reach of children, avoiding the heating of the blister and direct sunlight.

Shelf life of the medicine with proper storage is 2 years. At the end of the expiration date, the drug should not be taken orally.

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