Pancreatin tablets: instructions for use

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Pancreatin is a natural human pancreatic enzyme.

The drug is made from crushed pork gland. The main role of this substance is the cleavage of incoming nutrients and the improvement of their absorption in the intestine. Being an enzyme, pancreatin is not absorbed in the lumen of the digestive system, but exerts its effect directly on contact with food.

The use of Pancreatin helps to improve the digestion, ensures the normalization of digestion processes and improves the functioning of the gastrointestinal tract. The drug provides a replacement shortage of pancreatic enzymes, has amylolytic, lipolytic and proteolytic properties, enhances the cleavage of proteins, carbohydrates and fats in the duodenum gut.

The drug is characterized by a fairly fast and full absorption.

Clinical and pharmacological group

Enzyme means.

Conditions of leave from pharmacies

Released without a doctor's prescription.

Price list

How much does Pancreatin cost in pharmacies? The average price is at the level of30 rubles.

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Form of issue and composition

Pancreatin is available in the form of small tablets of brown color, covered with an intestine-soluble coating on top. The drug has a smooth shell of saturated color, which has a light brown tint on the fault. Pancreatin is produced in tablet form. The package contains five plates (10 tablets each).

  • Pancreatin (Pancreatinum) with minimal lipolytic enzyme activity from, ED Ph. Eur.. The minimum enzymatic activity of amylase is from, ED Ph. Eur.; proteolytic activity - from 200 units Ph. Eur ..

As auxiliary components in the preparation of various dosage forms of the drug are used: sodium chloride (Natrii chloridum), silicon dioxide colloid (Silicii dioxydum colloidale), microcrystalline cellulose (Cellulosum microcristallicum), colloid Cl (Kollidon Cl), magnesium stearate, polyacrylate 30% (Polyacrylate 30%), propylene glycol (Propylene glycol), talc (Talcum), titanium dioxide (Titanium dioxide), sodium carboxymethyl starch (starch glycolate), starch 1500 (Amylum 1500), povidone 8000 (Povidonum), dyes.

Pharmacological effect

The action of pancreatin is aimed at replenishment of insufficient secretion of enzymes by the pancreas. In the composition of pancreatin, there are three enzymes specific to fats, proteins and carbohydrates: lipase provides decomposition fats for glycerin and fatty acids, amylase cleaves the starch to simple saccharides, the protease decomposes proteins into amino acids.

Thanks to this, the three organic components of food are fully absorbed. Special coating of tablets ensures unhindered passage of the acidic environment of the stomach. Normalizes the processes of digestion of food in the duodenum, small intestine.

Indications for use

What helps pills Pancreatin? The main indications for the use of the medicine include:

  1. Remkheld's syndrome (gascocardial syndrome).
  2. Preparation for X-ray examination and ultrasound examination of the abdominal organs.
  3. Disturbance of the assimilation of food (state after resection of the stomach and small intestine).
  4. To improve the digestion of food in individuals with normal gastrointestinal function in the event of errors in nutrition (eating fatty foods, large amounts of food, irregular meals) and in cases of violations of masticatory function, sedentary lifestyle, prolonged immobilization.
  5. Substitution therapy with exocrine pancreatic insufficiency: chronic pancreatitis, pancreatectomy, condition after irradiation, dyspepsia, cystic fibrosis; flatulence, non-infectious diarrhea genesis.

Contraindications

Pancreatin in pregnancy is not recommended for use, but it is not included in the list of official contraindications. It is forbidden to take with individual sensitivity to the components of the composition, as well as a number of diseases.

You can not drink Pancreatin when:

  1. Empyema of the gallbladder;
  2. Hyperbilirubinemia;
  3. Hepatic insufficiency, precoma and coma;
  4. Acute pancreatitis;
  5. Period of exacerbation of chronic pancreatitis;
  6. Acute hepatitis;
  7. Intestinal obstruction;
  8. Mechanical jaundice;
  9. Chololithiasis;
  10. Syndrome of glucose-galactose malabsorption.

Use in pregnancy and lactation

There is no data on the safety of Pancreatin use by women during pregnancy. Therefore, appoint a drug to a woman during pregnancy can only a doctor, before analyzing the relationship of risk and benefits to the fetus and mother.

When breastfeeding the drug is also used only on indications.

Dosage and route of administration

The instructions for use indicate that the dose of Pancreatin (in terms of lipase) depends on the age and extent of pancreatic function deficiency.

  1. The average dose for adults is 15, 00 units / day. With total insufficiency of the exocrine function of the pancreas - 400 000 units / day, which corresponds to the daily needs of an adult in lipase.
  2. The maximum daily dose is 15 000 units / kg.
  3. Children under the age of 1.5 years - 50 000 U / day; over 1.5 years - 100 000 units / day.

Duration of treatment can vary from several days (with digestion due to inaccuracies in the diet) up to several months and even years (if necessary, a constant replacement therapy).

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Side effects

Against the background of taking Pancreatin tablets, it is possible to develop unwanted reactions from various organs and systems:

  • Metabolism - hyperurericia (increased excretion of uric acid), after taking the drug in high doses, it is possible to increase the level of uric acid in the blood.
  • Digestive system - a feeling of discomfort or pain in the abdomen, nausea, vomiting, constipation. Children may develop perianal irritation.
  • Allergic reactions - rarely develop skin manifestations in the form of rash and itching.

With the development of side effects, the doctor decides to cancel the drug on an individual basis, depending on their nature and severity.

Overdose

Overdose of Pancreatin according to reviews causes the following symptoms: hyperuricemia, hyperuricosuria. An overdose of the drug in children can cause constipation.

In these cases, the use of Pancreatin should be discontinued and symptomatic therapy should be given.

special instructions

Before you start using the drug, read the special instructions:

  1. It is not recommended to use chronic exacerbation of chronic pancreatitis in the phase.
  2. Cystic fibrosis does not recommend the use of pancreatin in doses greater than 10 000 units / kg / day (in terms of lipase) due to an increased risk of developing strictures (fibrous colonopathy) in the ileocecal region and in the ascending colonic gut.
  3. In cystic fibrosis, the dose should be adequate to the number of enzymes that are needed to absorb fat, taking into account the quality and quantity of food consumed.
  4. Disturbances from the digestive system can occur in patients with increased sensitivity to pancreatin, or in patients with meconium ileus or bowel resection in the anamnesis.
  5. With a high activity of lipase contained in pancreatin, the probability of constipation in children increases. Increase in the dose of pancreatin in this category of patients should be carried out gradually.

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

  1. With the simultaneous use of iron preparations, it is possible to reduce the absorption of iron.
  2. With simultaneous use, it is theoretically possible to reduce the clinical efficacy of acarbose.
  3. With simultaneous use with antacids, calcium-containing carbonate and / or magnesium hydroxide, a decrease in the effectiveness of pancreatin is possible.

Pancreatin and alcohol compatibility

Alcohol irritates the stomach and aggravates the digestive situation. Therefore, if you take both pancreatin and alcohol, the consequences will not take long. There may be indigestion, pain. So, answering the question about whether it is possible to accept together, the answer is affirmative. That is, in principle, they are compatible: no serious deterioration was observed. But is it possible to cure the disease with such a "therapy" - a controversial answer.

Reviews

We picked up some reviews of people who used pancreatin tablets:

  1. Olga. I never knew what Pancreatin is, although I heard it from many people. The only thing I know, when the fats are split, then all internal organs work easier. Began to take 1-2 tablets after each feast - the benefit of the drug is cheap. Guests we have often, but with this medicine I tolerate overeating much easier.
  2. Nastya. She gave Pancreatin to her 4 year old child when he had problems with a stool during rotavirus. The doctor prescribed to drink pills for 3 months so that it would be of use, but I was afraid, and gave my son a drug only for a month. The child recovered, the chair was adjusted, I found it superfluous to soak it with enzymatic pills for so long, so as not to be cured of other sores.
  3. Sasha. Pancreatin is a good drug, but only when it does not concern serious pancreatic problems. Yes, if you ate at a festive table, then 1-2 tablets of Pancreatin, like Mezima (a medicine of one property) will help you to digest the surplus that you have had. But with chronic pancreatitis, these drugs like elephant grains, it's better then take Creon, there will be more enzymes and the treatment will be effective. The only negative is the price. Therefore, all take Pancreatin, and if you calculate the price plus effect, the alignment will be different.

Analogues

There are several analogues, which are more expensive in value, but identical in effect. They are easy to find, order from the catalog and buy in online stores. These include:

  • Gastenorm forte;
  • Gastenorm forte 10000;
  • Creon 10000;
  • Creon 2, 00;
  • Creon 40000;
  • Mezim 20000;
  • Mezi forte;
  • Mezim forte 10000;
  • Mikrazim;
  • Pangrol 2, 00;
  • Pangrol 10000;
  • PanziKam;
  • Panzim Forte;
  • Panzinorm 10000;
  • Penzinorm forte 20000;
  • Pancreatym;
  • Pancreatin forte;
  • Pancreatin-LekT;
  • Pancrelipase;
  • Pantcitrate;
  • Penzital;
  • Festal N;
  • Enzistal-P;
  • Hermitage.

Before using analogues, consult your doctor.

Pancreatin or Mezim - which is better?

Mezima contains more basic enzyme, which contributes to the improvement of the digestive process. Therefore, the lack of Pancreatin reduces to the fact that the consumer acquires a "cat in a poke". But the effectiveness of the funds are similar. Therefore, what to choose, the doctor decides, especially if the treatment is performed during pregnancy.

In the normal state, both can be used independently. Considering the question of whether pancreatin or Mezim forte - which is better, it can be noted that there is no single answer. Although the difference between the drugs is present. The testimonies indicate that when answering the question "what is best for a child it is worth giving preference to Mezim. But when choosing Pancreatin or Mezim for pancreatitis, another drug leads.

Storage conditions and shelf life

The drug is stored for no more than 3 years in a place protected from the sun at a temperature of no higher than 25ºC. After the expiry of this period, the enzyme activity of the active substances decreases.


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