Nurofen tablets

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Nurofen is a potent pharmacological drug with an analgesic and antipyretic effect.

Nurofen is used to eliminate painful symptoms (pain, temperature and inflammation) with influenza, acute respiratory disease, acute respiratory infections, head, dental, muscular, articular and menstrual pain, with severe pain in the throat, neuralgia, migraines, as well as damage to ligaments, muscles and sports injuries.

When ingestion inhibits the formation of prostaglandins - substances that cause inflammatory reaction in the human body (the so-called mediators of inflammation), due to which there is an anti-inflammatory, analgesic and antipyretic effect.

Clinical and pharmacological group

NSAIDs.

Conditions of leave from pharmacies

Released without a doctor's prescription.

Price list

How much are Nurofen tablets in pharmacies? The average price is at the level of120 rubles.

Form of issue and composition

The drug Nurofen is available in the form of tablets, coated with a protective coating, for oral administration. The tablets are packed in foil blisters of 10 pieces each in a cardboard bundle, and an instruction sheet with a detailed description is attached to them.

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  • One tablet Nurofen contains in its composition 200 mg of active ingredient - Ibuprofen, in addition to the composition of the medicine includes auxiliary substances - silicon dioxide, stearic acid, croscarmellose sodium.
  • In the composition of one tabletNurofen Forte- 400 mg ibuprofen, as well as additional components: sodium citrate, sodium lauryl sulfate, sodium croscarmellose, stearic acid, sodium carmellose, silicon colloidal anhydride, titanium dioxide, acacia, sucrose, talc, macrogol 6000, industrial methylated alcohol, water.

On one side of the tablet there is a printed inscription in Latin letters with the name of the drug.

Pharmacological effect

Anti-inflammatory drug of non-hormonal nature, which has anti-inflammatory and antipyretic effects. Also has a mild antipyretic effect. The mechanism for achieving the therapeutic effect is associated with the selective blocking of enzymes leading to the formation of biologically active substances that have the opposite effect.

Nurofen is absorbed quickly enough and spreads over all tissues in a short time, mainly retaining in the periarticular fluid, where its maximum concentration is reached. This property of the drug is due to a high degree of binding to blood plasma proteins (about 90%). In the joint cavity, the drug falls into an insignificant degree or does not enter at all.

Neurofen is neutralized in the liver with the formation of active degradation products. His excretion occurs with the help of kidneys and bile. The time to remove the drug from the body is about 4 hours.

Indications for use

Nurofen is used in situations where it is necessary to quickly and effectively remove the pain syndrome. The indications are:

  1. Radiculitis.
  2. Shingles.
  3. Neuralgia.
  4. Painful menstruation.
  5. Headaches and migraines.
  6. Neuralgia of the trigeminal and facial nerve.
  7. An acute attack of toothache.
  8. Discomfort in the spine.
  9. Increased body temperature.

The drug also helps with febrile conditions, postural hypotension and to reduce the expression of proteinuria.

Through how much Nurofen works

According to the instructions for use, the drug is absorbed by the intestine, enters the blood. The fastest result is when using rectal suppositories. How much does Nurofen come into play? Time depends on its release form:

  • candles for children - 10 minutes;
  • suspension - a quarter of an hour;
  • preparations for adults - up to 30 minutes;
  • the composition of the express forte is a quarter of an hour.

Contraindications

Orally, the drug is not allowed in the third trimester of pregnancy, lactation, children under 6 years of age, as well as all patients with:

  1. Leukopenia;
  2. Diseases of the optic nerve;
  3. Scotom;
  4. Violation of color vision;
  5. Amblyopia;
  6. Hemorrhagic diathesis;
  7. Hemophilia and conditions of hypocoagulation;
  8. Aspirin bronchial asthma;
  9. Pathology of the vestibular apparatus and hearing loss;
  10. Expressed violations of the liver / kidney;
  11. Expressed heart failure;
  12. Severe arterial hypertension;
  13. Deficiency of glucose-6-phosphate dehydrogenase;
  14. Hives or rhinitis in the history, which were caused by the intake of acetylsalicylic acid or other NSAIDs;
  15. Hypersensitivity to ibuprofen or any other component of the drug;
  16. Erosion-ulcerative lesions of the gastrointestinal tract in the period of their exacerbation, including peptic ulcer of stomach and duodenum, Crohn's disease, peptic ulcer and ulcerative colitis.

In caution, Nurofen in the form of tablets is prescribed:

  1. With bronchial asthma;
  2. With blood diseases of unclear etiology;
  3. With autoimmune diseases, incl. with systemic lupus erythematosus;
  4. With arterial hypertension;
  5. When referring to a history of peptic ulcer disease of the stomach or duodenum;
  6. With chronic heart failure;
  7. In the first and second trimesters of pregnancy;
  8. Children from 6 to 12 years;
  9. With gastritis, colitis, enteritis and bleeding from the gastrointestinal tract;
  10. With hyperbilirubinemia;
  11. In the presence of concomitant diseases of the liver / kidney, including nephrotic syndrome, cirrhosis with portal hypertension.

Use in pregnancy and lactation

  1. Pregnant women in the first 12 weeks are not recommended the use of any medication, including Nurofen. During the research it was found that against the background of therapy with the drug in the first trimester of pregnancy, the fetus is at increased risk of forming a "hare lip" or "wolf mouth."
  2. In the second trimester of pregnancy, drug therapy is possible only if there are life indications in the case when the benefits for a woman far exceed the probable complications for the fetus. Treatment is carried out under the strict supervision of a physician.
  3. In the third trimester of pregnancy, Ibuprofen treatment is prohibited, as the risk of anemia of the hematopoietic fetal system, impaired renal function of the fetus or newborn and the risk of birth bleeding in a woman.

Since ibuprofen penetrates into breast milk, the use of Nurofen during breastfeeding is not recommended so as not to harm the child. If necessary, the patient should stop lactation.

Dosage and route of administration

The instructions for use indicate that Nurofen tablets are taken orally. They should be washed down with water. Patients with increased sensitivity of the stomach are advised to take the drug while eating.

The drug is intended only for short-term use. The interval between taking the tablets should be at least 6 hours.

  • Children over 12 years of age are prescribed 1 tablet. (200 mg) up to 3-4 times / day.
  • Children aged 6 to 12 years are prescribed 1 tab. (200 mg) up to 3-4 times / day; the drug can be administered only to children weighing more than 20 kg.

The maximum daily dose for children aged 6 to 18 years is 800 mg (4 tablets).

If during the use of the drug for 2-3 days the symptoms persist or worsen, it is necessary to stop treatment and consult a doctor.

Side effects

When Nurofen is used for 2-3 days, side effects are almost not observed. In the case of prolonged use, the following side effects may occur:

  1. On the part of the respiratory system: bronchospasm, dyspnea.
  2. From the cardiovascular system: heart failure, increased blood pressure, tachycardia.
  3. From the urinary system: nephrotic syndrome, acute renal failure.
  4. On the part of the hematopoiesis system: anemia, thrombocytopenia, thrombocytopenic purpura, agranulocytosis, and leukopenia.
  5. From the side of the organ of vision: blurred vision, diplopia, dryness and irritation of the eyes, edema of the conjunctiva and eyelids (allergic genesis).
  6. Allergic reactions: skin rash, itching, urticaria, Quincke's edema, Stevens-Johnson syndrome, Lyell's syndrome, eosinophilia, allergic rhinitis.
  7. On the part of the digestive system: nausea, vomiting, heartburn, anorexia, a feeling of discomfort in the epigastrium, diarrhea, flatulence, erosive ulcer lesions of the gastrointestinal tract, abdominal pain, irritation, dryness of the oral mucosa, aphthous stomatitis, pancreatitis, constipation, hepatitis.
  8. From the side of the central nervous system: headache, dizziness, insomnia, agitation, drowsiness, depression, confusion, hallucinations, hearing loss, tinnitus.
  9. Other: increased sweating.

With prolonged use in high doses: ulceration of the mucous membrane of the gastrointestinal tract, bleeding (including from the gastrointestinal tract, gums, uterine, hemorrhoidal), visual impairment (violation of color vision, amblyopia).

Overdose

Symptoms of an overdose: nausea, vomiting, pain in the epigastric region or, more rarely, diarrhea, tinnitus, headache and gastrointestinal bleeding.

In more severe cases, there are manifestations from the side of the central nervous system: drowsiness, rarely - excitation, convulsions, disorientation, coma. In cases of severe poisoning, metabolic acidosis and increased prothrombin time, renal failure, damage to liver tissue, decreased blood pressure, respiratory depression and cyanosis may develop. Patients with bronchial asthma may exacerbate this disease.

special instructions

Before you start using the drug, read the special instructions:

  1. During the period of treatment, ethanol is not recommended.
  2. In patients with bronchial asthma or allergic disease in the acute stage, as well as in patients with a bronchial asthma / allergic disease in the history of the drug can provoke bronchospasm.
  3. It is recommended to take the drug as short a course as possible and at the minimum effective dose necessary to eliminate symptoms. If you need to use the drug for more than 10 days, you need to see a doctor.
  4. During long-term treatment, control of the peripheral blood picture and the functional state of the liver and kidneys is necessary.
  5. The use of the drug in patients with systemic lupus erythematosus or a mixed disease of connective tissue is associated with an increased risk of developing aseptic meningitis.
  6. If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the test.
  7. When symptoms of gastropathy appear, careful monitoring including esophagogastroduodenoscopy, a general blood test (determination of hemoglobin), and analysis of feces for latent blood are shown.
  8. Patients with hypertension, incl. in anamnesis, and / or chronic heart failure should be consulted with a doctor before using the drug, because the drug can cause fluid retention, increased blood pressure and swelling.
  9. Patients with renal insufficiency should consult with a doctor before using the drug, since there is a risk of impairment of the functional state of the kidneys.
  10. The use of NSAIDs in patients with chickenpox may be associated with an increased risk of developing severe purulent complications Infectious-inflammatory diseases and subcutaneous fat (for example, necrotizing fasciitis). In this regard, it is recommended to avoid the use of the drug in case of chicken pox.
  11. Patients with uncontrolled hypertension, congestive heart failure class II-III in NYHA, IHD, peripheral arterial disease and / or cerebrovascular diseases should be prescribed only after a thorough assessment of the benefit / risk ratio, while ibuprofen should be avoided at high doses (≥ , 00 mg / day).
  12. Women planning pregnancy should take into account that the drug suppresses COX and the synthesis of prostaglandins, affects ovulation, disrupting female reproductive function (reversible after withdrawal of treatment).

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

  1. Ibuprofen increases the side effects of ethanol, estrogens, glucocorticosteroids and mineralocorticoids.
  2. Kolestyramin and antacids reduce the absorption of ibuprofen.
  3. Nurofen increases the plasma concentrations of methotrexate, digoxin and lithium preparations.
  4. Caffeine increases the analgesic effect of ibuprofen.
  5. With the simultaneous use of Nurofen, cefotetan, plikamycin, cefoperazone, valproic acid and cefamandol increase the incidence of hypoprothrombinemia.
  6. It is not recommended simultaneous use of ibuprofen with acetylsalicylic acid and other NSAIDs (antiaggregant and anti-inflammatory the effect of the latter), as well as with thrombolytic and anticoagulant drugs (increased risk of bleeding).
  7. Drugs that block tubular secretion, increase the concentration of ibuprofen in plasma. Inductors microsomal oxidation (barbiturates, phenylbutazone, phenytoin, tricyclic antidepressants, rifampicin, ethanol) increase the risk of severe hepatotoxic reactions, and the inhibitors of microsomal oxidation have the opposite effect.
  8. Gold preparations and cyclosporin increase the nephrotoxicity of ibuprofen, which in turn increases the concentration cyclosporine in plasma and increases the likelihood of hepatotoxic action of the latter.
  9. Nurofen reduces natriuretic effect of hydrochlorothiazide and furosemide, hypotensive effect of vasodilators and effectiveness of uricosuric agents; strengthens the effect of fibrinolytic agents, antiaggregants, indirect anticoagulants and oral hypoglycemic agents (insulin and sulfonylurea derivatives).

Reviews

We picked up some reviews of people who used Nurofen tablets:

  1. Zoya. Mom know what it means to give a child a medicine - then spit it out, then vomiting will appear. It turned out that there is an antipyretic medicine - a delicious baby suspension Nurofen, and even at an inexpensive price - very happy. The baby drinks the medicine with pleasure, but the main thing is that it is possible to quickly knock down the temperature. An excellent remedy for colds.
  2. Angelica. Do not panic when the five-month-old daughter has a fever. What to do - put the injections, but if the pill, then how to give? Thanks to the pediatrician - it turned out that there are Nurofen suppositories, for which, according to the instructions, application is possible from 3 months. The temperature was brought down after the second use. Very convenient to apply, the effect is fast.
  3. Irina. Very good drug. I have never used it before. And my pediatrician prescribes it as anti-inflammatory for colds. Therefore, we are just about to begin to drink this syrup. It really helps. I read a lot of side effects. It frightens, of course, this. But I hope that we often do not accept it and do not accept debt either. Yes, and I always try to reduce the dosage, if possible. While I did not see anything like this with my child.

Analogues

Structural analogs for the active substance:

  • Advance;
  • ArthroCam;
  • Bonifen;
  • Brufen;
  • Burana;
  • Deblock;
  • Children's Motrin;
  • Dolgit;
  • Ibuprom;
  • Ibuprofen;
  • Ibuprofen Lannacher;
  • Ibuprofen Nycomed;
  • Ibuprofen-Hemofarm;
  • Ibusan;
  • Ibutop gel;
  • Ibufen;
  • Iprene;
  • MIG 200;
  • MIG 400;
  • Nurofen for children;
  • Nurofen Period;
  • Nurofen UltraKap;
  • Nurofen fort;
  • Nurofen Express;
  • Pedee;
  • Solpaflex;
  • Faspik.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Store at a temperature not exceeding + 25 ° C. Keep away from children. Shelf life - 3 years.


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