Temperature after vaccination against influenza

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Temperature after vaccination against influenza.

Answers:

Dawn

Systemic reactions to influenza vaccination can be represented by the following symptoms: fever; malaise; weakness; chills; fatigue; headache; severe sweating; pain in the muscles (myalgia) and joints (arthralgia).
l These symptoms can be observed for up to 2 days after drug administration, and then pass on their own without treatment.

Yasha Stefankin

go to sleep

The Bold

Sit at home until it passes. This happens. My daughter also had (((

El-Farot

This is permissible. Take the hospital.

Rudolf Lazarenko

Take procetamol, 1 tablet, take a more cooling shower and then cover it warmly the next morning like a hand with nimit

Ivantrs

Well, of course, it should be so

a vaccine is a weakened virus, the body must cope and create protection against this virus

the only problem is that a flu vaccine can not exist :)

flu - constantly mutating

and you make vaccinations against viruses that do not already exist

absolutely meaningless action :)

Andrey Anikeev

Go to where the vaccine was done and ask in full!

instagram viewer

dalina

urgently see the film "truth about vaccinations" Tsarevo

Vaccination against influenza

Vaccination against influenza only since 2006 is included in the National Calendar. In Europe, there is a continuous record of cases of influenza, and although it is far from complete, an inoculation against influenza has led to a decrease in the incidence.

According to WHO, with annual epidemics of influenza, 5-10% of adults and 20-30% of children fall ill, 250 000-500 000 people die from this disease, economic damage amounts to 1 to 6 mln. dollars per 100 000 population.

A vaccine against influenza should be given to patients-chroniclers, who are often ill with ARI, children of preschool age. In the countries of Europe, the elderly, patients with cardiac, pulmonary (including bronchial asthma) and renal pathology, diabetes and people with immunosuppression are vaccinated. In the USA since 2008 Inoculation against influenza is older than 6 months. introduced into the National Calendar.

Influenza vaccination in children

Vaccination against influenza should be carried out in the first year, because at this age there is a high incidence and severe course. Thus, in the 2007/08 season, the share of children 0-2 years among those who developed the flu was 38.4%, 3-6 years - 43.5%, while schoolchildren only 14%, and adults - 2.8%. Among the children hospitalized with confirmed influenza, 50% were children under the age of 6 months, 2/3 - children under 1 year and 80% - up to 2 years. In another study, it was shown that of the number of children who are sick with influenza at the age of 2-5 years, every 250th, 6-24 months is hospitalized. - every 100th. and 0-6 months. - every 10th.. According to the combined data of the American Academy of Pediatrics, the hospitalization rate for this disease is 240-720 per 100 000 children 0-6 months. and 17-45 per 10, 00 children aged 2-5 years; 37% of those hospitalized were at risk - their hospitalization rate was 500 per 100 000.

And although the death rate of children is 1/10 of the death rate of older persons (0.1 and 1.0 per 100 000), a special study in the United States of this issue in 2004-2005. showed that the children of the first half of this indicator is 0.88 per 100 000.

Symptoms of influenza in young children often differ from the classical picture - high fever + intoxication + cough and runny nose. At this age, febrile convulsions are frequent against the background of fever, the flu often causes croup, bronchiolitis, exacerbation of asthma, often complicated by otitis media, sinusitis and pneumonia. The frequency of otitis media in children with influenza is 18-40% according to different tori, much more often in children under 2 years old. Complication of myocarditis, as well as from the nervous system - is not uncommon. So, in one of the studies of 842 children with confirmed laboratory flu in 72 there were neurological complications: encephalopathy in 10 children, febrile convulsions in 27 and afebrile - in 29, meningitis 2 and cerebral stroke due to hypotension - in 4.

Who should be vaccinated?

The contingents listed in the National Calendar do not include a number of groups whose flu vaccine gives a certain effect and can be recommended; The immunoprophylaxis calendar for epidemiological indications does not decode the risk groups. The recommendations in force in the United States are presented below, the flu shot should be administered to the following categories of people:

  • Healthy children over the age of 6 months.
  • Asthma and other chronic lung diseases such as cystic fibrosis.
  • Diseases of the heart with hemodynamic disorders.
  • Conditions that are fraught with impairment of respiratory functions (aspiration, sputum stasis) - epilepsy, neuromuscular diseases, spinal cord injuries, mental retardation
  • Immunodeficiencies, including HIV infection.
  • Sickle cell anemia and other hemoglobinopathies.
  • Chronic kidney disease, metabolism, diabetes,
  • Diseases requiring long-term therapy with acetylsalicylic acid (rheumatic diseases, Kawasaki syndrome) as prevention of Reye's syndrome.
  • Family members and staff caring for children under the age of 5 (especially important for children under 6 months of age).

These recommendations, although they do not include such obvious risk groups as patients with organic lesions of the central nervous system, influenza causes long-term apnea, children with malformations of the lungs and bronchopulmonary dysplasia, are quite acceptable for our conditions. Of course, we should also recommend vaccination on an individual basis to all children and adults.

Vaccination against influenza for people with chronic diseases is safe. Published enough convincing work, allowing to vaccinate these contingents.

Contraindications to the vaccination against influenza

For all vaccines - an allergy to egg hen proteins, to aminoglycosides (for vaccines containing them), allergic reactions to the administration of any vaccine. Split- and subunit vaccination against influenza can be used in persons with chronic pathology, incl. with immune defects, pregnant and lactating women, patients with immunosuppressive therapy, combine with other vaccines (in different syringes). It is not recommended to vaccinate people who have undergone Guillain-Barre syndrome.

Contraindications for live vaccines - immunodeficiency states, immunosuppression, malignant neoplasms, rhinitis, pregnancy, intolerance of chicken protein. Temporary contraindications, as for inactivated vaccines, are acute diseases and exacerbations of chronic.

Vaccination reactions and complications

The live vaccine against influenza is slightly reactogenic, the temperature above 37.5 ° in the first 3 days is allowed for no more than 2% of the vaccinated. When subcutaneous injection of whole-cell vaccines, it is allowed to develop a short-term temperature above 37.5 ° or infiltrates up to 50 mm in no more than 3% of the vaccinated. With their intranasal administration, subfebrile within 1 to 3 days is allowed for no more than 2% of the vaccinated.

Subunit and split vaccines give weak short-term (48-72 hours) reactions in no more than 3% of the vaccinated. The least reactogenic according to international independent studies are subunit vaccines. Clinical experience confirms the low reactogenicity of inactivated sipit and subadynamic vaccines and in children even in the second half of life. The largest amount (about 7, 00 doses) of vaccine safety is from the United States. There are observations that the vaccine against influenza is safe in children in the first half of the year.

Rare cases of vasculitis are described. Observations in England for 34 000 vaccinated with different vaccines (of which 75% with chronic pathology) showed a low incidence of all and allergic reactions (in total, within 1-3% for different vaccines).

Rare, immediate reactions after the vaccine against influenza Grippol was introduced in 2006. in the subsequent, they were practically not repeated.

Vaccines against influenza

The vaccine against influenza is prepared from the current strains of A / H1N1 /, A / H3N2 / and B viruses, recommended annually by WHO. Vaccination against influenza is carried out in the autumn, preferably before the onset of morbidity.

Instead of the previously released anti-influenza gamma globulin, a normal human immunoglobulin is used in a doubled dosage.

Currently, a vaccine against influenza is being tested, which is based not on hemagglutinin and neuraminidase, but on the matrix protein 1 and virion nucleoprotein that do not mutate; if successful, there will be no need for an annual vaccination.

Live vaccines are made from attenuated strains of the virus (adapted to cold mutants), they are able to produce local immunity (production of IgA antibodies) with intranasal administration. In the USA, where a live vaccine has been used since 5 years, incl. in children with asthma, it is shown to be more effective than the inactivated vaccine against A / H1N1 and B.

Allantoin intranasal live flu vaccine is dry for children aged 3 years and adults (Microgen, Russia) - lyophilizate for solution preparation. The contents of the ampoule are dissolved in 0.5 ml (1 dose) of boiled water (cooled). The age-appropriate vaccine is administered once in 0.25 ml in each nasal passage to a depth of 0.5 cm. attached by the spray dispenser type RD single use.

Vaccination against influenza is weakly reactogenic. Storage of drugs at a temperature of 2 to 8. Shelf life - 1 year.

Inactivated all-virion vaccination against influenza is used in children older than 7 years and adults. It is a purified virus, cultured on chick embryos, inactivated by UV irradiation.

Grippovak (NIIVS, Russia) contains in 1 ml of 20 μg hemagglutinin subtypes A and 26 μg B. Preservative - merthiolate. Form release: 1 ml ampoules (2 doses), vials of 40 or 100 doses. Store at 2-8 °. Introduced to children from 7 years and adolescents intranasal (spray RDZH-M4) to 0.25 ml in each nasal passage twice with an interval 3-4 weeks, adults - from 18 years - intranasal in the same scheme or parenterally (SC) once in a dose of 0.5 ml.

Vaccination against influenza inactivated eluate-centrifuge liquid (Russia) - is applied according to the same scheme as Grippovac

Subunit and split vaccines are used in children older than 6 months, adolescents and Roslyh. Children vaccinated for the first time and neoblevshim influenza, as well as patients with immunodeficiency is recommended to enter 2 doses with an interval of 4 weeks, in subsequent years - once. With the introduction of 1 dose in the spring and one fall, the vaccines are less immunogenic

A vaccine against influenza is injected intramuscularly or deeply subcutaneously into the upper third of the outer surface of the shoulder. The vaccines are stored at 2-8 °. Shelf life 12-18 months.

Subunit and split vaccines registered in Russia

Vaccination against influenza Composition, preservative Doses and methods of vaccination

Grippol

Subunit-Microgen, Russia

5 μg of 2 strains of A and 11 μg of strain B, + polyoxidonium of 500 μg, merthiolate. Ampoules 0.5 ml

Children 6 months - 3 years 2-fold to 0.25 ml with an interval of 4 weeks. over 3 years - 0.5 ml each 1 time.

Grippol® plus

Polymer-subunit - Petrovax FC, Russia

5 μg 2 strains A and B (Solvay Biolodzh.) + Polyoxidonium 500 μg, without preservative. Syringe, amp., 0.5 ml bottles

Children over 3 years and adults at 1 dose (0.5 ml) once

Agrippal S1 - Subunit, Novartis Vaccine and Diagnostics Srl, Italy

15 mcg 3 strains, without cone. Syringe-dose.

Children older than 3 years and adults 1 dose (0.5 ml) once, up to 3 years - 1/2 dose (0.25 ml) - vaccinated for the first time and not sick of the flu - 2 times after 1 month.

Begrivak Split, New Artis Vaccine, Germany

15 mcg 3 strains, without preservative. Syringe-dose

Vaxigrip Split, sanofi pasteur, France

For 15 mcg 3 strains, no preservative. Syringe doses, amp. 0.5 ml, 10 dose vials

Children under 9 years 2-fold, 0.25 ml (up to 3 years) or 0.5 ml (3-8 years); > 9 years - 1 dose of 0.5 ml.

Inflexal V

Subunit, Berna Biotech, Switzerland

For 15 μg 3 strains; virosomes mimic the virion. Without preservatives, formaldehyde and antibiotics

Children older than 3 years and adults - 0.5 ml IM or deeply n / k, children from 6 months. up to 3 years in 0.25 ml (previously not vaccinated with 2 doses).

Influwak

Subunit, Solvay Pharma, The Netherlands

15 mcg 3 strains, free of preservatives and antibiotics. Self-destroying syringe-dose.

Persons> 14 years 0.5 ml. Children

Fluarix Split, SmithKlein Forms. GmbH, KG, Germany

15 μg 3 strains, traces of merthiolate and formaldehyde. Syringe-dose.

Children over 6 years of 0.5 ml once, 6 months - 6 years - 0.25 ml 2-fold

A cell culture-grown subunit vaccine against influenza On-taflu, Novartis Vaccine and Diagnosis GmbH, FRG and Split Vaccine FluvaxiN, ChangchukLife Science Ltd., China, is registered.

A vaccine against influenza is not active against avian influenza viruses and possible future mutants. Vaccines from "avian" strains in case of an epidemic have been created in Russia and other countries.

Is the flu vaccine effective?

The vaccination against influenza develops immunity 14 days after the injection, but in children who did not previously have contact with the virus, this requires 2 doses of the vaccine administered at intervals of 4-6 weeks. Immunity is type-specific; Vaccination against influenza should be carried out every year, since there is an antigenic drift of strains of viruses, as well as its short duration (6-12 months), even if its strain composition, in comparison with the previous season, has not changed.

Vaccination against influenza has a prophylactic efficacy against a laboratory-confirmed disease of 60-90%, although the degree of protection in children and the elderly is considered to be lower. When infected with strains of the virus, different from vaccine, the effectiveness is reduced; although the disease in vaccinated flows more easily, but the incidence of influenza and mortality remain above the epidemic threshold.

Vaccination against influenza is the most effective method of reducing the incidence of influenza and mortality from it both among the general population and at risk groups. A vaccination against influenza reduces the hospitalization of children aged 6-23 months. (who received 2 doses of the vaccine) by 75%, and mortality by 41%, and the protective effect of the vaccination, carried out for 2 years or more, is much higher than the one-time before the epidemic. Among adults with community-acquired pneumonia vaccinated against influenza, during the influenza season, mortality was lower - RR 0.3 (0.22-0.41). Especially pronounced effect among the elderly: for 10 seasons, the relative risk of pneumonia was 0.73 and death - 0.52.

Vaccination against influenza also reduces the incidence of children with acute otitis media (by 2.3-5.2%) and exudative otitis media (by 22.8-31.1%). Vaccination against influenza reduces the frequency of all ARI.

To protect children of the first half of this disease, the effect of vaccination of pregnant women is studied. Data from Bangladesh showed that this flu shot has an efficacy of 63%: up to the age of 24 weeks, 4% of children were infected with influenza, compared to 10% in controls. In addition, the frequency of febrile ARI decreased by 29%.

The problem of bird flu

The highly pathogenic avian influenza virus (H5N1) multiplies in the intestines of birds - its neuraminidase N1 is resistant to acidic medium, and haemagglutinin H5 recognizes epithelial receptors containing sialic acids characteristic of birds. There are few such receptors (therefore people rarely get sick), but the trachea of ​​pigs contains both types of sialic acids, which makes them the main "mixer" of viruses. Mass transmission from a person to a person is possible only if the specificity of the hemagglutinin of the avian virus changes.

Post-exposure prophylaxis

Vaccination against influenza should be performed before the beginning of the cold season. During the epidemic, interferon-a-nasal drops of Alfaron, Grippferon (1, 00 U / ml) and in aeozoles are used: children 0-1 years, 1 drop (, 00 ME); 1-14 years old - 2 each, older than 14 years and adults - 3 drops 2 times a day for 5-7 days (in contact with a sick person) or an age-related dose in the morning every 1-2 days (during the epidemic season). The same scheme uses Viferon 1 candles. Interferon-gamma (Ingaron - 100 000 ME in a vial, diluted in 5 liters of water) for children over 7 years and adults for 2 drops in the nose: in contact with a sick flu - once, in the season of epidemics - 2-3 drops 30 minutes before meals after the toilet of the nose 1 time every other day 10 days (repeated course if necessary - after 2 weeks).

For prevention in adults and children older than 1 year, use rimantadine (tablets 50 mg, 2% syrup for children Algeria with sodium alginate), although the virus A1 has become resistant to it. Doses of rimantadine: 100 mg / day (children 7-10 years), 150 mg / day (children over 10 years and adults); Algirem: children 1-3 years 10 ml (20 mg) children 3-7 years - 15 ml: (30 mg) - once a day for 10-15 days. Similar effect in Arbidol - according to the same scheme: children 2-6 years - 0.05, 6-12 years - 0.1, over 12 years - 0.2 g.

The neuraminidase inhibitor oseltamivir (Tamiflu) is approved for the treatment and prevention of influenza A and B from 1 g. When administered within 36 hours after contact with the patient, warns of influenza in 80%, is active with avian flu (but not with ARVI). Prophylactic dose for children 1-2 mg / kg / day, for adults - 75-150 mg / day - 7 days after contact or up to 6 weeks during the epidemic. Zanamivir (Relenza in an aerosol is used from the age of 5 years for 2 inhalations 2 times a day (total 10 mg / day) treatment and prevention.

Vaccination against influenza in people with chronic diseases

Vaccination against influenza in the form of split and subunit vaccines has shown its effectiveness and safety when administered to patients with severe pathology (asthma, leukemia, liver transplant recipients, diabetes, multiple sclerosis, etc.). Clinical experience of vaccination of more than , 00 children, 31 of them with various pathologies, showed its safety and effectiveness.

ilive.com.ua

Do I need a flu vaccine?

Vaccination against influenza, prevention of the disease - this is a very important point. Warnings are always more important than healing later. To date, there is no panacea for influenza, there is not a single miracle drug that guarantees a quick and complete cure, so vaccinations against influenza act as prevention of the disease. It is very important to prevent the disease by vaccinating on time. Every year more and more people are grafted from this dangerous disease.

Vaccination against influenza for prevention

However, there are both opponents and supporters of this procedure. There is no clear, concrete answer about the benefits or harm of vaccination against influenza. Vaccination should be carried out after studies and individually.

This vaccination is not included in the vaccination calendar and is paid for the adult, but for children it is still free of charge.

Vaccination against influenza in Russia occurs voluntarily, each person has the right to make his choice - for or against, and for the kids the choice is made by the parent.

The word "flu" came from the French "grab", "catch". The definition speaks of the suddenness and rapidity of the virus's entry into the body. Influenza is a dangerous infectious disease that is acute and usually affects the respiratory system and is expressed by the following symptoms:

  • heat;
  • severe weakness;
  • general deterioration of the condition;
  • pain in the head;
  • pain in the muscles;
  • nausea, vomiting.

Dangerous influenza viruses, what is the danger, the testimony

Seasonal influenzaThe flu can get sick at any time of the year. But usually people get sick all the same in the autumn and in the winter, because at this time the body lacks vitamins, the premises are not ventilated and temperature drops occur. In the autumn-winter period, the epidemic of the disease usually occurs. Small children, whose age is more than half a year, can get sick, as the antibodies transmitted by the mother cease to have a protective function. The disease is caused by influenza viruses A, B, C. The flu virus mutates easily, so the flu vaccine for children and adults should be given annually. Once the virus enters the upper respiratory tract, it immediately captures the mucosa and destroys its cells.

Cells are rejected and during coughing, sneezing, breathing enter the external environment, infecting others. Such infection is called in medicine "air-drop path". You can get into and through personal hygiene items, underwear. Once the virus has entered the body, the symptoms of the disease begin to manifest, there is a sharp weakness, up to 40 degrees the body temperature rises, the head turns, even convulsions may develop, the mucus, the throat pershit, are released from the nose. When a person has been ill with the flu, it acquires a kind of immunity to the disease, but the problem is that the virus mutates and the antibodies that are produced will not have any protection in the fight against the mutated virus.

Influenza is very dangerous, because it completely suppresses the human immune system. In addition, the flu provokes an aggravation of other diseases.

Complications after infection can be as follows:

  • acute inflammation of the lungs;
  • otitis media;
  • changes in the work of the central nervous system;
  • altered processes in the work of the heart and blood vessels.
Warnings of the Ministry of Health about vaccinationsThe Ministry of Health recommends vaccination as the only way to avoid infection and create immunity to a terrible disease. WHO (World Health Organization) identified the at-risk groups to whom the flu vaccine is indicated, these are people:
  • including children who are often ill with different infections;
  • with the diagnosis "bronchial asthma";
  • suffering from CNS diseases;
  • with heart disease or vascular problems;
  • with kidney disease;
  • with blood diseases;
  • who have diabetes mellitus;
  • with deficiency of the body's defense system;
  • who go to kindergartens and schools.

An effective influenza vaccine is improved every year, as the virus is constantly mutating. The experience of scientists allows creating an effective and safe vaccine. The vaccination with the drug that was made this year will be ineffective next year, and therefore the vaccination against the flu with the improved drug is carried out annually. As the statistics showed, the vaccine works, but can not guarantee 100% that the person will not get sick, however even in the case of infection, the disease will proceed in a lighter manner and severe consequences will not occur.

Best vaccine against influenza, vaccination scheme, when should be vaccinated against influenza

Vaccination with VaxgrippusLive and inactivated vaccines are now used for inoculation. Live vaccines are now used very rarely, as the development of live vaccines of the newest generation is underway. But the inactivated vaccine practically does not give serious consequences. This vaccine can be:
  • whole cell;
  • split-vaccine;
  • subunit.

The difference between drugs is that they differently split the virus into component particles. The whole cell vaccine causes complications, has contraindications, but at the same time creates a stable immunity to influenza. The most dangerous to date are the second and third type of vaccine. They practically do not give complications. These drugs do not harm even a child, actively stimulate the immune system and do not cause adverse reactions. Today, 11 influenza vaccines are used and allowed in Russia. Most often do vaccination with drugs:

  • "Flight-arix";
  • "Vaxigripp";
  • "Begrivac";
  • "Influvac";
  • "Grippol".

How does the vaccine work?

Low temperature after flu vaccineAfter the drug is administered to a person, the process of producing antibodies occurs. This creates a layered protection. 14 days after vaccination, the body accumulates a sufficient number of antibodies, and the body does not perceive the disease. Protective protein immediately recognizes the virus and eliminates it.

Immunity persists up to six months or throughout the year. The effectiveness of immunization reaches 90%. This means that the probability of catching the flu is, but it is negligible compared to if the vaccination was not done in time. Today there is a standard vaccination scheme. Vaccination begins in September or October, due to which by the winter the body develops immunity to influenza. It is very important to get vaccinated before the epidemic. Babies can be vaccinated after the age of six months. Babies who have not yet been vaccinated against influenza, it is recommended to vaccinate twice in half the dosage for an adult with an interval of 30 days. The inoculation is done intramuscularly or very deep under the skin.

Modern vaccines against influenza practically do not give a negative reaction after administration, occasionally vaccinated people may have a fever or a puffiness around the site of the injection. You can not vaccinate people who are allergic to a particular component of the drug, such as a protein or preservative. Do not administer the vaccine during the period of illness. You can only be vaccinated a month after the illness has passed. You can not get a flu shot if there were complications during the previous vaccination.

The vaccine must be taken in a licensed medical facility. Vaccination should be carried out by an experienced doctor. After the drug has been introduced, the doctor must issue a certificate, which will include all the data on the drug. You can not buy the vaccine alone. Science today has proven the high efficacy of anti-influenza drugs, especially for toddlers at risk. One should or should not be vaccinated - this should be discussed with the pediatrician and individually.

Implications after vaccination, vaccination rules

Otitis after vaccinationAfter vaccination, the following complications can not often occur:
  1. Inflammation of lungs bacterial type. If the temperature does not drop more than five days - this is a sign of pneumonia.
  2. Reduced immunity.
  3. Sinusitis.
  4. Otitis of acute form.
  5. False groats.
  6. Myositis.
  7. Meningitis.
  8. Exacerbation of chronic respiratory diseases.

Vaccination can be free, paid and passive immunization. Schools, kindergartens and a polyclinic purchase the vaccine at the expense of money allocated by the municipality. This vaccine is issued in Russia. Some employers also provide free vaccination. Fee paid for vaccination in private clinics, and the price depends on the drug and on the cost of the service itself.

Attention! Acquired vaccines against influenza should be stored according to the rules prescribed in the instructions, otherwise the drug will lose its valuable properties. It is strictly forbidden to vaccinate independently.

respiratoria.ru

You can drink antibiotics after being vaccinated against the flu, if the temperature lasts 3 days 38-3, ? Sore throat and general malaise?

Answers:

yanna to.

Only on the testimony of a doctor. Especially in you, rather, the reaction to vaccination and antibiotics may not work, only to harm. Cut down the temperature and perform symptomatic treatment, treat the throat. There will be no improvement - go to the doctor.

Indifferent

antibiotics are contraindicated for independent use by housewives of average mental development. It is fraught ...

Olyushka Laptev

it's a reaction to the inoculation, you'll need to wait a while, and so treat yourself rinse your throat, rinse your nose, necessarily febrifuge. Vitamins.
no more vaccination against influenza.

After being vaccinated against the flu, I get sick all the time. the temperature is then a little higher. what to do?

Answers:

Senkevich Ksenia

Congratulations, you have the flu!
what to do - to be treated for the flu and no longer to prick the questionable quality of domestic vaccines!

Anabiosis

If you are sick for a long time and strongly, after every vaccination, show yourself to the doctors. If weakly and seldom then do not worry, the body is fighting))

claudia lever

It was not necessary to do an inoculation - now it is treated.

DDD

We have three friends almost died, now the cannon shot will not be allowed with this pest of vaccination against influenza

Neko ~ nya

Discard the vaccine or certainly consult a doctor. It is normal, if the body has adverse reactions to the vaccine. And although the percentage of people in this reaction is very small, you may have fallen into this amount.

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